The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(17), P. 11722 - 11734
Published: Aug. 15, 2022
In
this
study,
we
report
a
novel
and
efficient
synthetic
method
to
construct
isoquinolone
scaffold
via
the
Rh(III)-catalyzed
(4
+
2)
annulation
of
benzamide
with
an
unreported
coupling
reagent
methyl
2-chloroacrylate.
Accordingly,
other
valuable
1,2-benzothiazine
naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine
derivatives
are
also
obtained
through
similar
protocol.
Thus,
our
developed
is
highlighted
by
high
yield
reaction
versatility.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(49), P. 9086 - 9091
Published: Dec. 2, 2022
A
modular
multicomponent
reaction
of
readily
available
fluoroalkyl
alkenes,
amidines,
ammonium
carbonate,
and
water
was
developed
for
the
facile
construction
β-fluoroalkylated
aminovinyl
ketones,
which
provided
chemists
a
novel
access
to
value-added
organofluorine
compounds.
The
proceeded
regio-/stereoselectively
under
mild
conditions
exhibited
good
functional
group
tolerance.
Cheap,
stable,
low-toxic
inorganic
salt
(NH4)2CO3
first
found
act
as
both
nitrogen
source
carbonyl
equivalent
in
multi-bond-forming
process.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 27, 2024
Abstract
Nitrogen‐containing
heterocycles
represent
fundamental
components
found
in
a
myriad
of
natural
compounds,
pharmaceuticals,
tailored
bioactive
substances,
and
agrochemicals.
In
recent
decades,
the
field
synthetic
chemistry
has
prioritized
these
directing
considerable
research
endeavour
toward
developing
efficient
concise
methodologies
for
their
synthesis.
Consequently,
there
is
growing
interest
pioneering
novel
approaches
to
fabricate
immensely
coveted
structural
motifs.
Transition
metal‐catalyzed
reactions
leveraging
solvents
as
carbon
(C1)
synthons
offer
notable
advantages,
including
streamlined
processes,
enhanced
atom
economy,
environmental
sustainability.
This
review
sheds
light
on
advancements
utilization
collective
such
methanol
(alongside
other
alcohols),
N,N
‐dimethylethanolamine
(DMEA),
triethylamine
(TEA)
(in
conjunction
with
amines),
tetrahydrofuran
(THF),
toluene,
dichloromethane
(DCM),
dimethyl
sulfoxide
(DMSO),
dimethylformamide
(DMF)
C1
synthons,
serving
foundational
units
synthesis
N
‐heterocycles,
quinazolinone,
quinazoline,
quinoxaline,
pyridine,
pyrimidine,
among
others.
Various
reaction
conditions
employing
diverse
transition
metals,
coupling
partners,
or
reagents,
reported
literature,
have
been
explored.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(9)
Published: July 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(19), P. 5532 - 5537
Published: Jan. 1, 2024
Chemodivergent
synthesis
of
polysubstituted
pyrroles
and
pyridines
from
N
-allyl
enaminones
via
tandem
site-selective
bromination
the
highly
regioselective
Heck
reaction.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(17), P. 11722 - 11734
Published: Aug. 15, 2022
In
this
study,
we
report
a
novel
and
efficient
synthetic
method
to
construct
isoquinolone
scaffold
via
the
Rh(III)-catalyzed
(4
+
2)
annulation
of
benzamide
with
an
unreported
coupling
reagent
methyl
2-chloroacrylate.
Accordingly,
other
valuable
1,2-benzothiazine
naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine
derivatives
are
also
obtained
through
similar
protocol.
Thus,
our
developed
is
highlighted
by
high
yield
reaction
versatility.
