Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds DOI Open Access
Er‐Jun Hao,

Xiaobo Ding,

Kexin Wang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(12), P. 4057 - 4057

Published: Jan. 1, 2023

( a 河南师范大学化学化工学院 抗病毒性传染病创新药物全国重点实验室 平原实验室 绿色化学介质与反应教育部

Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor–Acceptor Aziridines with Isocyanides DOI
Fengcai Zhang, Xinpeng Sang, Yuqiao Zhou

et al.

Organic Letters, Journal Year: 2022, Volume and Issue: 24(7), P. 1513 - 1517

Published: Feb. 11, 2022

The enantioselective [3 + 1]-cycloaddition of racemic donor-acceptor (D-A) aziridines with isocyanides was first realized under mild reaction conditions using a chiral N,N'-dioxide/MgII complex as catalyst, providing facile route to enantioenriched exo-imido azetidines good excellent yield (up 99%) and enantioselectivity 94% ee). An obvious amplification effect observed in this system, an explanation elucidated based on the experimental investigation X-ray crystal structure enantiomerically pure catalyst.

Language: Английский

Citations

17
Regioselective and asymmetric allylic alkylation of vinyl epoxides for the construction of allylic alcohols via synergistic catalysis DOI
Min Chen,

Longqing Yang,

Yuzhen Li

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 67(2), P. 542 - 550

Published: Nov. 17, 2023

Language: Английский

Citations

10
Recent Advances in Cycloaddition Reactions of Donor-Acceptor Aziridines via Carbon-Carbon Bond Cleavage DOI Open Access
Zuliang Chen,

Yingjing Wei,

Junliang Zhang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(9), P. 3078 - 3078

Published: Jan. 1, 2023

There are two different ring-opening modes of aziridines: aziridines via carbon-nitrogen bond cleavage, and carbon-carbon cleavage.Among them, the reaction cleavage has been reported in many reviews.The cycloaddition reactions donor-acceptor (D-A) recent 20 years mainly summarized.Under some proper catalysts, D-A yield azomethine ylides, which can undergo [3＋n] with aldehydes, imines, alkenes, alkynes, indoles etc.

Language: Английский

Citations

4
Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines DOI
Pei Dong, Zhaojing Li, Xiaohua Liu

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(17), P. 4591 - 4597

Published: Jan. 1, 2022

An asymmetric cascade reaction catalyzed by a chiral N , ′-dioxide–Dy( iii ) complex was realized to construct the valuable [6,5,5,6] tetracyclic spiroindolines with good yields and enantioselectivities concise one-step protocol.

Language: Английский

Citations

7
Intramolecular Copper-Catalyzed Asymmetric Propargylic [4 + 2]- Cycloaddition toward Optically Active Tetrahydroisoindolo[2,1-a]quinoxalines DOI
Ling Li,

Xiu-Shuai Chen,

Xiang‐Ping Hu

et al.

Organic Letters, Journal Year: 2022, Volume and Issue: 24(29), P. 5433 - 5438

Published: July 20, 2022

An intramolecular Cu-catalyzed asymmetric propargylic [4 + 2] cycloaddition of bis-N-nucleophile-functionalized esters has been realized in the support a chiral tridentate N-ligand, (S,S)-Pybox-diOAc, leading to tetrahydroisoindolo[2,1-a]quinoxalines high yields and with good excellent enantioselectivities. The reaction features efficiency, simplicity, broad substrate scope, thus providing powerful concise strategy for stereoselective access optically active polycyclic heterocycle frameworks that are otherwise difficult synthesize.

Language: Английский

Citations

6
[3+2] Cycloaddition of Nitrile Imines with 3‐Benzylidene Succinimides: A Facile Access to Functionalized Spiropyrazolines DOI

Cheng Yuan,

Xiaojun Ning,

Tao Gao

et al.

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 11(2)

Published: Jan. 27, 2022

Abstract A wide range of substituted spiro‐pyrazoline derivatives containing the pyrrolidinone core have been prepared by alkalic treatment 3‐benzylidene succinimides and nitrile imines. All reactions proceeded under mild conditions products were isolated column chromatography in good yields with high diastereoselectivity. Furthermore, this method featured several advantages such as functional group tolerance simple scalability.

Language: Английский

Citations

5
Diastereoselective Construction of Spirocyclic Isobenzofurans via a Tandem Michael Addition/5-Exo-dig Cyclization Reaction DOI

Shaghayegh Mehdidoust,

Saideh Rajai‐Daryasarei,

S. Sina Hosseini

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16613 - 16621

Published: Oct. 31, 2024

A practical approach for rapid and efficient access to spirocyclic isobenzofurans is described. The reaction proceeds through the cycloaddition of 1,6-ynenone derivatives 4-nitro-1,3-diarylbutan-1-ones, promoted by Cs

Language: Английский

Citations

0
Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds DOI Open Access
Er‐Jun Hao,

Xiaobo Ding,

Kexin Wang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(12), P. 4057 - 4057

Published: Jan. 1, 2023

( a 河南师范大学化学化工学院 抗病毒性传染病创新药物全国重点实验室 平原实验室 绿色化学介质与反应教育部

Citations

1