Solvent-controlled synthesis of bulky and polar-bulky galactonoamidines DOI Creative Commons
Susanne Striegler, Ifedi Orizu

Carbohydrate Research, Journal Year: 2022, Volume and Issue: 513, P. 108520 - 108520

Published: Feb. 10, 2022

Language: Английский

GC–MS, FTIR and physico-chemical analysis of phytochemicals from Vellore floral waste and its in-silico studies DOI
Swati Punetha, Suneetha Vuppu

Chemical Papers, Journal Year: 2023, Volume and Issue: 77(11), P. 6873 - 6905

Published: Aug. 24, 2023

Language: Английский

Citations

2
N‐Methyl‐N‐Alkylaminocyclopentanes: Powerful and Selective β‐d‐Glucocerebrosidase Inhibitors DOI
Patrick Weber, Roland C. Fischer, Seyed A. Nasseri

et al.

Helvetica Chimica Acta, Journal Year: 2024, Volume and Issue: 107(4)

Published: Feb. 13, 2024

Abstract Building upon a previously established (2+3)‐cycloaddition strategy, series of N , ‐dialkylated aminocyclopentanes was synthesized using partially protected eno‐furanose as the starting point. The resulting ‐methylisoxazolidine subsequently transformed into corresponding aminocyclopentane, which further ‐alkylated, yielding collection compounds with potential inhibitors and pharmacological chaperones β‐ d ‐glucocerebrosidase. A comprehensive screening involving range biologically relevant glycosidases unveiled that these exhibit remarkable potency selectivity human lysosomal However, none significant activity enhancement Morbus Gaucher related p.N409S/p.L483P mutant

Language: Английский

Citations

0
Synthesis and glycosidase inhibition of 3,4,5-trihydroxypiperidines using a one-pot amination-cyclisation cascade reaction DOI Creative Commons
Emma M. Dangerfield,

Michael A. Meijlink,

Alex A. Hunt‐Painter

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 543, P. 109198 - 109198

Published: June 27, 2024

Trihydroxypiperidines are a therapeutically valuable class of iminosugar. We applied one-pot amination-cyclisation cascade reaction to synthesise 3,4,5-trihydroxypiperidine stereoisomers in three steps from commercially available pentoses and excellent overall yields. Using our methodology, the yields syntheses meso-1, meso-2 3L highest reported date. The synthetic methodology was readily extended three-step synthesis N-alkyl derivatives by replacing ammonia nitrogen source with primary amine. trihydroxypiperidines analogues were screened for enzyme inhibitory activity using Fabrazyme (Fabry disease), GCase (Gaucher's Agrobacterium sp. β-glucosidase, Escherichia coli β-galactosidase. N-Phenylethyl (N-phenylethyl-1-(3R,4R,5S)-piperidine-3,4,5-triol) showed good (K

Language: Английский

Citations

0
Effects of sponge-derived polybrominated diphenyl ethers on human cancer cell α-N-acetylgalactosaminidase and bacterial α-d-galactosidase and their antioxidant activity DOI Creative Commons
Н. К. Уткина, Svetlana P. Ermakova, I. Yu. Bakunina

et al.

Environmental Science Advances, Journal Year: 2022, Volume and Issue: 2(2), P. 294 - 303

Published: Dec. 20, 2022

Spongean PBDEs had no effects on α-NaGalase. Compounds 1 and 2 at micromolar levels inhibit α-PsGal from the marine bacterium Pseudoalteromonas sp. Weak antioxidant activity is not responsible for effectiveness of inhibition.

Language: Английский

Citations

1
Solvent-controlled synthesis of bulky and polar-bulky galactonoamidines DOI Creative Commons
Susanne Striegler, Ifedi Orizu

Carbohydrate Research, Journal Year: 2022, Volume and Issue: 513, P. 108520 - 108520

Published: Feb. 10, 2022

Language: Английский

Citations

0