ChemistryOpen,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
This
research
introduces
the
preparation
and
analysis
of
a
newly
heterogeneous
catalyst
developed
silica
nanospheres
supporting
ferrocene‐containing
ionic
liquid
(IL)
(SiO
2
@Benzothiazole‐Cl@Fc)
for
A3
coupling
reaction.
The
facilitates
efficient
synthesis
1,3,5‐trisubstituted
pyrazoles
from
aromatic
hydrazides,
aldehydes,
alkynes.
Incorporating
ferrocene
enhances
catalytic
activity.
Comprehensive
characterization
techniques,
including
NMR,
Fourier
transform
infrared,
transmission
electron
microscopy,
energy‐dispersive
X‐ray
spectroscopy,
scanning
confirm
successful
functionalization
nanospheres.
performance
was
evaluated
under
various
reaction
conditions,
demonstrating
high
yields
selectivity
desired
pyrazole
products.
work
highlights
potential
ferrocene‐based
ILs
in
green
chemistry
applications,
providing
sustainable
approach
to
synthesizing
valuable
heterocyclic
compounds.
Current Organocatalysis,
Journal Year:
2024,
Volume and Issue:
11(4), P. 321 - 329
Published: Feb. 2, 2024
Background:
MCRs
are
one
of
the
most
significant
tools
in
synthesis
organic
compounds.
MCR
is
a
rapid
chemical
technique
that
uses
three
or
more
reactants
to
produce
products
sustain
all
structural
and
substructural
properties
initial
components.
useful
fields
synthetic
chemistry
because
their
rate
reaction,
simple
procedure
excellent
yields.
We
reported
an
efficient
environmentally
friendly
domino
approach
for
spiroheterocycles
spiro
annulated
with
indeno[1,2-b]quinoline.
Method:
The
privileged
heterocyclic
substructures
have
been
synthesized
using
taurine
(2-aminoethanesulfonic
acid)
as
green,
sustainable,
bio-organic
recyclable
catalyst
three-component
reaction
isatins,
1,3-diketones,
1-napthylamine
aqueous
media.
present
method
probably
first
report
synthesize
spiroheterocycles,
spiroannulated
Furthermore,
valuable
yield
results
from
15-20
min.
Result:
optimization
conditions
important
case
synthesis.
solvent,
temperature,
time
loading
were
examined.
reusability
was
also
investigated
experimentally.
used
has
high
activity
well
good
reusability.
protocol
will
be
extended
synthesise
library
hybrid
cost-effective,
time-efficient
easy-workup
methodology
gives
outstanding
yields
(80–95%)
15–20
Conclusion:
Taurine-catalyzed
multicomponent
novel
indeno[1,2-b]quinolines.
catalytic
water
green
solvent
makes
process
friendly.
special
features
include
efficiency,
operational
simplicity,
it
expected
make
contributions
not
only
drug
discovery
studies
but
pharmaceutical
therapeutic
view
introducing
molecular
diversity
molecules.
