European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2022(2)
Published: Dec. 13, 2021
Abstract
It
is
a
challenging
task
to
simultaneously
achieve
selective
depolymerization
and
valorization
of
lignin
due
their
complex
structure
relatively
stable
bonds.
We
herein
report
an
efficient
strategy
that
employs
2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone
(DDQ)
as
oxidant/catalyst
selectively
convert
different
oxidized
models
wide
variety
2‐phenylbenzimidazole‐based
compounds
in
up
94
%
yields,
by
reacting
with
o‐phenylenediamines
varied
substituents.
This
method
could
take
full
advantage
both
C
β
and/or
γ
atom
furnish
the
desirable
products
instead
forming
byproducts,
thus
exhibiting
high
economy.
Furthermore,
this
can
effectively
transform
hardwood
(birch)
softwood
(pine)
into
corresponding
degradation
45
wt%
30
wt%,
respectively.
Through
“one‐pot”
process,
we
have
successfully
realized
oxidation/depolymerization/valorization
natural
birch
at
same
time
produced
benzimidazole
derivatives
67
total
yields.
Journal of Saudi Chemical Society,
Journal Year:
2022,
Volume and Issue:
26(6), P. 101561 - 101561
Published: Oct. 5, 2022
Biopolymers
like
cellulose,
polysaccharides,
chitosan,
starch,
chitin,
and
alginates
have
sparked
an
increasing
curiosity
in
creating
natural
replacements
for
synthetic
polymers
during
the
last
several
decades.
Chitin
is
a
major
part
of
fungi's
cell
walls,
crustaceans'
exoskeletons,
lobsters,
crabs,
shrimps,
cephalopod
beaks,
radulae
mollusks,
fish
lissamphibians
scales.
Since
late
1970
s,
biopolymer
chitosan
has
gathered
interest
basic
science
applied
research
due
to
its
incredible
macromolecular
framework,
physicochemical
properties,
biological
activities,
which
differ
from
those
polymers.
derivatives
thereof
practical
usages
chemistry,
agriculture
sector,
medicine,
cosmetics,
as
well
textile
paper
industries.
Chitosan
also
received
lot
recent
fields
dentistry,
ophthalmology,
veterinary
science,
biomedicine,
drink
industry,
hygiene
personal
care,
catalysis,
chromatography,
sewage
treatment,
biotechnology.
Numerous
fundamental
investigations
been
conducted
on
chitin
chitosan.
This
article
presents
short
compact
summary
over
two
decades
attempt
highlight
works
applications.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(10), P. 5624 - 5630
Published: March 2, 2023
A
cooperative
catalyst
system
involving
a
Pd(0)/Senphos
complex,
tris(pentafluorophenyl)borane,
copper
bromide,
and
an
amine
base,
is
demonstrated
to
catalyze
trans-hydroalkynylation
of
internal
1,3-enynes.
For
the
first
time,
Lewis
acid
shown
promote
reaction
emerging
outer-sphere
oxidative
step.
The
resulting
cross-conjugated
dieneynes
are
versatile
synthons
for
organic
synthesis,
their
characterization
reveals
distinct
photophysical
properties
depending
on
positioning
donor/acceptor
substituents
along
conjugation
path.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
62(7)
Published: Dec. 10, 2022
Abstract
Scholl
oxidation
has
become
an
essential
reaction
in
the
bottom‐up
synthesis
of
molecular
nanographenes.
Herein,
we
describe
a
controlled
by
electronic
effects
on
starting
substrate
(
1
,
b
).
Anthracene‐based
polyphenylenes
lead
to
spironanographenes
under
conditions.
In
contrast,
electron‐deficient
anthracene
affords
helically
arranged
nanographene
formed
two
orthogonal
dibenzo[fg,ij]phenanthro‐[9,10,1,2,3‐pqrst]pentaphene
(DBPP)
moieties
linked
through
octafluoroanthracene
core.
Density
Functional
Theory
(DFT)
calculations
predict
that
control
either
first
formation
spirocycles
and
subsequent
form
spironanographene
2
or
expected
dehydrogenation
leading
solely
helical
3
.
The
crystal
structures
four
new
spiro
compounds
syn
9
anti
10
)
were
solved
single
X‐ray
diffraction.
photophysical
properties
reveal
remarkable
dual
fluorescent
emission.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(5), P. 3266 - 3276
Published: Feb. 16, 2023
A
[3
+
2]
cycloaddition
reaction
of
N-aminopyridines,
N-aminoquinolines,
and
N-aminoisoquinolines
with
1-bromoethene-1-sulfonyl
fluoride
(BESF)
was
performed
to
obtain
optimum
yields
various
useful
pyrazolo[1,5-a]pyridinyl,
pyrazolo[1,5-a]quinolinyl,
pyrazolo[5,1-a]isoquinolinyl
sulfonyl
fluorides
(43–90%
yield).
The
transformation
process
showed
broad
substrate
specificity,
mild
conditions,
operational
simplicity.
Therefore,
the
has
great
applicable
value
in
field
medicinal
chemistry
other
disciplines.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(35)
Published: June 20, 2023
We
disclose
a
highly
regioselective,
catalytic
one-step
dehydrogenation
of
α-substituted
cyclic
ketones
in
the
presence
2,3-dichlorobenzo-5,6-dicyano-1,4-benzoquinone
(DDQ).
The
high
regioselectivity
originates
from
phosphoric
acid-catalyzed
enolization,
selectively
affording
thermodynamically
preferred
enol,
followed
by
subsequent
oxidation
event.
Our
method
provides
reliable
access
to
several
α-aryl
and
α-alkyl
substituted
α,β-unsaturated
ketones.
BMC Chemistry,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Jan. 29, 2025
For
paediatric
patients
suffering
from
neurofibromatosis,
Selumetinib
(SEL)
is
the
only
approved
drug.
Here
an
original
ecofriendly
and
high
pace
method
introduced
using
96-
microwell
spectrophotometric
assay
(MW-SPA)
to
measure
SEL
content
in
bulk
commercial
pharmaceutical
formulation
(Koselugo®
capsules).
This
was
relied
on
in-microwell
formation
of
a
coloured
charge
transfer
complex
(CTC)
upon
interaction
with
2,3-dichloro-5,6-dicyano-1,4-benzoquinone
(DDQ).
The
fully
characterized
by
computational
studies.
CTC
exhibited
absorbance
maximum
(λmax)
at
440
nm.
ease
reaction
occurrence,
stability
its
absorptivity
were
proved
measuring
association
constant
(0.63
×
102
L/
mol),
standard
free
energy
change
(-10.31
KJ/mol),
molar
(ε)
(3.78
103
L/mol/cm),
SEL:
DDQ
stoichiometric
ratio
(1:1).
Establishments
optimum
values
applied
conditions
96-well
plate
refined
regarding
concentration,
time,
temperature,
solvents.
Validation
according
ICH
guidelines.
linear
SEL'
concentrations
ranged
10
200
µg/well,
limits
detection
quantitation
4.1
12.5
respectively.
Then,
efficaciously
adapted
accurately
precisely
determine
form
Koselugo®
capsules.
environmental
safety
documented
three
different
comprehensive
metric
tools.
Additionally,
assessment
assay's
rate
demonstrated
throughput,
enabling
processing
large
number
samples
quality
control
laboratories.
successful
development
this
provides
valuable
fast
green
analytical
tool
for
ensuring
SEL's
