Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

Advances in Polymer Technology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM hydrophilic, while above it, the becomes hydrophobic, making it ideal thermosensitive drug delivery systems (DDSs). In tissue engineering, provides biocompatible, nontoxic and stimuli‐responsive surface cell culture. Its nature ensures safety in medical applications. enhances biosensing diagnostics through affinity biomolecules, improving accuracy. Widely used hydrogels, smart textiles, soft robotics various applications, adapts to environmental changes. straightforward synthesis allows creation diverse copolymers composites, applicable selective reactions conjugations with fluorescent tags or chemical modifications. PNIPAM’s versatility extends pH‐responsive alternatives, broadening application spectrum. Practical examples include separation water treatment cleaning processes. This discussion explores biomedical particularly cancer treatment, photothermal therapy (PTT) photodynamic (PDT), gene imaging. Additionally, highlights noncancerous such as small interfering RNA (siRNA) targeting oncogenes detailed imaging deep tumour tissues.

Language: Английский

Multiplexing fluorescent sensors for highly acidic range pH, Fe3+ ion, and temperature based on amphiphilic block copolymer

Colloid & Polymer Science, Journal Year: 2022, Volume and Issue: 301(1), P. 41 - 49

Published: Nov. 16, 2022

Language: Английский