Organic Process Research & Development,
Journal Year:
2023,
Volume and Issue:
27(1), P. 227 - 232
Published: Jan. 11, 2023
The
importance
of
rapid
access
to
diagnostics
tools
in
the
identification
pathogens─including
their
crucial
component,
bioreagents─was
recently
underscored
COVID-19
pandemic.
currently
adopted
synthesis
dithiothreitol
(DTT)
involves
four
steps
batch
with
long
reaction
times
and
which
generates
a
highly
carcinogenic
mutagenic
bis-epoxide
intermediate.
In
this
work,
we
have
developed
an
intensified
telescoped
three-step
continuous
flow
DTT
involving
base-mediated
ring
closure
epoxidation,
nucleophilic
epoxide
opening
thioacetic
acid,
acid-mediated
deacetylation.
One
key
features
is
that
first
two
are
conducted
fashion,
allowing
generation
consumption
hazardous
intermediate
situ,
suppressing
need
for
its
isolation,
improving
overall
safety
synthesis.
process
completed
by
acid-catalyzed
deacetylation
subsequent
recrystallization
afford
desired
DTT.
Flow
chemistry
allows
here
intensify
using
high
temperatures
pressures
while
minimizing
number
unit
operations
process.
Our
protocol
permits
on-demand
production
case
future
outbreaks.
Organic Process Research & Development,
Journal Year:
2022,
Volume and Issue:
26(6), P. 1766 - 1793
Published: June 2, 2022
The
concept
and
practices
of
chemical
synthesis
are
being
profoundly
transformed
toward
the
development
fully
autonomous
continuous
processes.
Critical
to
processes
is
efficient
monitoring
reaction
composition
product
quality
by
in-line
online
analyses.
in-line/online
acquisition
analytical
data
allows
one
monitor
at
regular
intervals
composition,
including
hazardous
or
air-sensitive
intermediates
with
possibility
adapting
parameters
interrupting
flow
process
when
a
technical
failure
detected.
This
review
presents
main
tools
that
can
be
integrated
into
reactors
for
reactions.
contribution
more
guide
service
synthetic
chemists
illustrated
selected
published
examples
from
leading
research
laboratories
than
an
exhaustive
list
articles.
Ultimately,
we
would
like
this
answer
following
recurrent,
yet
complex,
question:
"Which
is/are
most
suitable
solution(s)
my
reaction?".
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
South
Africa's
rich
natural
resources
remain
a
key
driver
of
its
chemical
industrialisation
but
are
tainted
and
constrained
by
complex
colonial
history.
Thirty
years
since
the
advent
democracy
in
Africa,
deep
sociopolitical
inequalities
amplified
an
intolerable
infectious
disease
burden
amongst
disadvantaged
communities.
In
that
respect,
Africa
shares
challenges
with
many
other
nations
Global
South;
there
limited
opportunities
for
economic
development
growth
needed
to
uplift
all
strata
society.
This
Viewpoint
examines
role
sciences
unique
history
current
state
academic
industrial
sectors,
focus
on
intersection
chemistry,
healthcare
biomedical
research.
We
argue
offered
through
chemistry
research
development,
including
local
manufacturing,
should
be
exploited
scientific
advancements
tailored
integrated
socioeconomic
realities
effective
multidisciplinary
approach
improving
outcomes.
aims
inspire
renewed
pivotal
scientists
their
broader
societal
contributions
combating
country's
shaping
healthier
future
Africa.
Lab on a Chip,
Journal Year:
2022,
Volume and Issue:
23(5), P. 1349 - 1357
Published: Oct. 12, 2022
For
decades,
a
production
paradigm
based
on
centralized,
stepwise,
large
scale
processes
has
dominated
the
chemical
industry
horizon.
While
effective
to
meet
an
ever
increasing
demand
for
high
value-added
chemicals,
so-called
macroscopic
batch
reactors
are
also
associated
with
inherent
weaknesses
and
threats;
some
of
most
obvious
ones
were
tragically
illustrated
over
past
decades
major
industrial
disasters
impactful
disruptions
advanced
supplies.
The
COVID
pandemic
further
emphasized
that
change
in
was
necessary
sustain
increased
safety,
reliable
supply
chains
adaptable
productivities.
More
than
decade
research
technology
development
led
alternative
relying
miniaturised
flow
(a.k.a.
micro
mesofluidic
reactors).
Such
bear
potential
solve
safety
concerns
improve
reliability
chains.
Will
they
initiate
new
more
localized,
safe
production?
Annual Review of Chemical and Biomolecular Engineering,
Journal Year:
2023,
Volume and Issue:
14(1), P. 109 - 140
Published: April 11, 2023
Alternative
polymer
feedstocks
are
highly
desirable
to
address
environmental,
social,
and
security
concerns
associated
with
petrochemical-based
materials.
Lignocellulosic
biomass
(LCB)
has
emerged
as
one
critical
feedstock
in
this
regard
because
it
is
an
abundant
ubiquitous
renewable
resource.
LCB
can
be
deconstructed
generate
valuable
fuels,
chemicals,
small
molecules/oligomers
that
amenable
modification
polymerization.
However,
the
diversity
of
complicates
evaluation
biorefinery
concepts
areas
including
process
scale-up,
production
outputs,
plant
economics,
life-cycle
management.
We
discuss
aspects
current
research
a
focus
on
major
stages,
selection,
fractionation/deconstruction,
characterization,
along
product
purification,
functionalization,
polymerization
manufacture
macromolecular
highlight
opportunities
valorize
underutilized
complex
feedstocks,
leverage
advanced
characterization
techniques
predict
manage
increase
fraction
converted
into
products.
Artificial Intelligence Chemistry,
Journal Year:
2024,
Volume and Issue:
2(2), P. 100075 - 100075
Published: July 27, 2024
The
beginning
and
ripening
of
digital
chemistry
is
analyzed
focusing
on
the
role
artificial
intelligence
(AI)
in
an
expected
leap
chemical
sciences
to
bring
this
area
next
evolutionary
level.
analytic
description
selects
highlights
top
20
AI-based
technologies
7
broader
themes
that
are
reshaping
field.
It
underscores
integration
tools
such
as
machine
learning,
big
data,
twins,
Internet
Things
(IoT),
robotic
platforms,
smart
control
processes,
virtual
reality
blockchain,
among
many
others,
enhancing
research
methods,
educational
approaches,
industrial
practices
chemistry.
significance
study
lies
its
focused
overview
how
these
innovations
foster
a
more
efficient,
sustainable,
innovative
future
sciences.
This
article
not
only
illustrates
transformative
impact
but
also
draws
new
pathways
chemistry,
offering
broad
appeal
researchers,
educators,
industry
professionals
embrace
advancements
for
addressing
contemporary
challenges
Communications Chemistry,
Journal Year:
2022,
Volume and Issue:
5(1)
Published: Nov. 10, 2022
Abstract
Traditional
optimization
methods
using
one
variable
at
a
time
approach
waste
and
chemicals
assume
that
different
parameters
are
independent
from
another.
Hence,
simpler,
more
practical,
rapid
process
for
predicting
reaction
conditions
can
be
applied
to
several
manufacturing
environmentally
sustainable
processes
is
highly
desirable.
In
this
study,
biaryl
compounds
were
synthesized
efficiently
an
organic
Brønsted
acid
catalyst
in
flow
system.
Bayesian
optimization-assisted
multi-parameter
screening,
which
employs
one-hot
encoding
appropriate
acquisition
function,
rapidly
predicted
the
suitable
synthesis
of
2-amino-2′-hydroxy-biaryls
(maximum
yield
96%).
The
established
protocol
was
also
efficient
2,2′-dihydroxy
biaryls
(up
97%
yield).
optimized
successfully
gram-scale
synthesis.
We
believe
our
algorithm
beneficial
as
it
screen
reactor
design
without
complicated
quantification
descriptors.
Reaction Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
9(5), P. 990 - 1013
Published: Jan. 1, 2024
This
review
highlights
the
advantages
of
incorporating
Process
Analytical
Technologies
into
continuous
flow
processes,
especially
in
context
telescoped
multistep
sequences.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(32)
Published: April 2, 2024
Abstract
Small
carbo‐
and
heterocyclic
ring
systems
have
experienced
a
significant
increase
in
importance
recent
years
due
to
their
relevance
modern
pharmaceuticals,
as
building
blocks
for
designer
materials
or
synthetic
intermediates.
This
necessitated
the
development
of
new
methods
preparation
these
strained
focusing
on
effectiveness
scalability.
The
high
strain
entities
well
use
high‐energy
reagents
intermediates
has
often
challenged
synthesis.
Continuous
flow
approaches
thus
emerged
highly
effective
means
safely
reliably
access
scaffolds.
In
this
short
review,
key
developments
field
are
summarised
showcasing
power
continuous
accessing
3‐
4‐membered
via
thermal,
photo‐
electrochemical
processes.
