Process Intensification and Increased Safety for the On-Demand Continuous Flow Synthesis of Dithiothreitol, a Crucial Component in Polymerase Chain Reaction Testing Kits DOI
Maryne A. J. Dubois, Virginie Carreras, Matt R. Adams

et al.

Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 27(1), P. 227 - 232

Published: Jan. 11, 2023

The importance of rapid access to diagnostics tools in the identification pathogens─including their crucial component, bioreagents─was recently underscored COVID-19 pandemic. currently adopted synthesis dithiothreitol (DTT) involves four steps batch with long reaction times and which generates a highly carcinogenic mutagenic bis-epoxide intermediate. In this work, we have developed an intensified telescoped three-step continuous flow DTT involving base-mediated ring closure epoxidation, nucleophilic epoxide opening thioacetic acid, acid-mediated deacetylation. One key features is that first two are conducted fashion, allowing generation consumption hazardous intermediate situ, suppressing need for its isolation, improving overall safety synthesis. process completed by acid-catalyzed deacetylation subsequent recrystallization afford desired DTT. Flow chemistry allows here intensify using high temperatures pressures while minimizing number unit operations process. Our protocol permits on-demand production case future outbreaks.

Language: Английский

Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis DOI
Zhexuan Lei, Hwee Ting Ang, Jie Wu

et al.

Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 28(5), P. 1355 - 1368

Published: March 30, 2023

Continuous flow synthesis is a widely used method for synthesizing fine chemicals due to its benefits such as process intensification, improved reproducibility, and the ability perform otherwise impossible transformations. Multistep continuous (MCFS) simplifies of complex molecules by telescoping multiple steps into streamlined potentially automated process, reducing human efforts time. Despite these advantages, challenges solid formation, solvent reagent incompatibilities, intermediate purification difficulties limit development MCFS. Overcoming will accelerate innovative MCFS, thereby leading enhanced multistep synthesis. This Perspective highlights representative examples molecule production enabled where various in-line technologies were utilized during processes.

Language: Английский

Citations

10
Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa DOI Open Access
Clinton G. L. Veale, John G. Woodland, Kathryn J. Wicht

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract South Africa's rich natural resources remain a key driver of its chemical industrialisation but are tainted and constrained by complex colonial history. Thirty years since the advent democracy in Africa, deep sociopolitical inequalities amplified an intolerable infectious disease burden amongst disadvantaged communities. In that respect, Africa shares challenges with many other nations Global South; there limited opportunities for economic development growth needed to uplift all strata society. This Viewpoint examines role sciences unique history current state academic industrial sectors, focus on intersection chemistry, healthcare biomedical research. We argue offered through chemistry research development, including local manufacturing, should be exploited scientific advancements tailored integrated socioeconomic realities effective multidisciplinary approach improving outcomes. aims inspire renewed pivotal scientists their broader societal contributions combating country's shaping healthier future Africa.

Language: Английский

Citations

0
Reshaping Chemical Manufacturing Towards Green Process Intensification: Recent Findings and Perspectives DOI Open Access
Giancarlo Cravotto

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 459 - 459

Published: Feb. 8, 2025

The chemical industry faces major challenges despite recent progress in the transition to more environmentally friendly processes. Sustainable industrial chemistry relies on optimization of protocols and downstream processes such as extraction, purification, drying. Process intensification, which includes non-conventional techniques continuous manufacturing, has emerged a key strategy improve efficiency environmental impact. Technologies ultrasound, microwaves, mechanochemistry, reactive extrusion offer improved performance but face scalability proprietary barriers. Flow offers additional benefits, including smaller reactors, lower energy consumption (from 40 90%), increased safety through continuous, automated reactions. However, implementing these methods requires overcoming engineering, economic, regulatory hurdles. Biphasic catalysis sonochemical activation liquid–liquid systems are promising approaches for scalable reactions under mild conditions. pharmaceutical industry, source waste, shown resistance due high validation costs complex regulations. Fortunately, international institutions have introduced programs facilitate introduction advanced technologies. Future perspectives emphasize integration modular, intensified with digitalization smart manufacturing. Collaborative, transdisciplinary research will be crucial accelerating commercialization addressing sustainability production.

Language: Английский

Citations

0
Inline purification in continuous flow synthesis – opportunities and challenges DOI Creative Commons
Jorge García‐Lacuna, Marcus Baumann

Beilstein Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 18, P. 1720 - 1740

Published: Dec. 16, 2022

Continuous flow technology has become the method of choice for many academic and industrial researchers when developing new routes to chemical compounds interest. With this maturing over last decades, robust oftentimes automated processes are now commonly exploited generate fine building blocks. The integration effective inline analysis purification tools is thereby frequently achieve reliable processes. This perspective article summarizes recent applications different techniques such as chromatography, extractions, crystallization from laboratories. A discussion advantages drawbacks these provided a guide aid in selecting most appropriate approach future applications. It hoped that contributes developments field context process cost efficiency, sustainability uptake chemistry developed academia.

Language: Английский

Citations

16
Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes DOI Creative Commons
Parth Naik, Jorge García‐Lacuna, Patrick O’Neill

et al.

Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 28(5), P. 1587 - 1596

Published: Sept. 7, 2023

A simple and benign continuous flow oxidation protocol for the selective conversion of primary secondary alcohols into their respective aldehyde ketone products is reported. This approach makes use catalytic amounts TEMPO in combination with sodium bromide hypochlorite a biphasic solvent system. variety substrates are tolerated including those containing heterocycles based on potentially sensitive nitrogen sulfur moieties. The can be coupled inline reactive extraction by formation carbonyl-bisulfite adduct which aids separation remaining substrate or other impurities. Process robustness evaluated preparation phenylpropanal at decagram scale, trifluoromethylated oxazole building block as well late-stage intermediate anti-HIV drug maraviroc demonstrates potential value this method.

Language: Английский

Citations

9
Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent DOI
Junu Kim, Yusuke Hayashi, Sara Badr

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2023, Volume and Issue: 62(43), P. 17824 - 17834

Published: Oct. 19, 2023

This work presents hybrid modeling of an active pharmaceutical ingredient flow synthesis in a ring-opening reaction epoxide with Grignard reagent. Conducting this batch reactor is challenging due to its fast and highly exothermic nature, which makes it difficult collect kinetic data. To address this, experiment was conducted varying parameters, such as the inner diameter temperature, information. A one-dimensional mechanistic model then developed, two mechanisms were assessed, Swain Boyles mechanism found show better results than Meisenheimer Casper mechanism. In model, impact changes diameters considered by adjusting pre-exponential factor function Reynolds number, simplifies effort needed consider effects relative development two-dimensional models. The further difficulty generation impurities, underlying still unclear. tackle challenge, data-driven approach, random forest regression adopted quantify them. adoption part enabled quantification impurity high accuracy, demonstrating potential strength approach when not all are fully understood. Overall, allowed for deeper understanding improved ability predict behavior.

Language: Английский

Citations

8
Scaled up and telescoped synthesis of propofol under continuous-flow conditions DOI Open Access
Guilherme M. Martins,

Maria F. A. Magalhães,

Timothy J. Brocksom

et al.

Journal of Flow Chemistry, Journal Year: 2022, Volume and Issue: 12(3), P. 371 - 379

Published: July 19, 2022

Language: Английский

Citations

12
Continuous flow synthesis of C-acyloxy-substituted aziridines in microchannel reactor: Addition of carboxylic acids to 2-methylenaziridines DOI
Haotian Sun, Bin Pan, Shanshan Zhang

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 138, P. 154982 - 154982

Published: Feb. 27, 2024

Language: Английский

Citations

2
Systematic study of FFF materials for digitalizing chemical reactors with 3D printing: superior performance of carbon-filled polyamide DOI
Victoria A. Korabelnikova, Evgeniy G. Gordeev, Valentine P. Ananikov

et al.

Reaction Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 8(7), P. 1613 - 1628

Published: Jan. 1, 2023

A simple methodology for testing FFF parts was developed to examine key factors chemical applications. Carbon-filled polyamide (PA6-CF) found superior digital design of reactors due advantageous combination properties.

Language: Английский

Citations

6
Hybrid Lean Practices Integrated with IR 4.0 and Sustainability in Malaysia Food and Beverages Companies: Conceptual Framework and Hypothesis Development DOI Creative Commons
Muslim Diekola Akanmu, Norshahrizan Nordin

Pertanika journal of science & technology, Journal Year: 2022, Volume and Issue: 30(3), P. 2271 - 2293

Published: May 25, 2022

The growing competition within manufacturing practices has motivated organizations to upgrade their conventional production system a smart, sophisticated systems. This study evaluates the impact of lean (LMP) and industrial revolution 4.0 technologies on sustainability in food beverages industry. Past literature revealed that significantly affect sustainable performance. However, integrated effects IR performance have not been examined empirically. In order fill void this gap, intends preliminary investigation combined LMP performance, specifically Furthermore, aims confirm future direction industry is recently employing new its underpinned by theories contingency practice-based view highlighting contributions operations management implement successful strategies enhancing companies through variations. extends current as enablers economic, environmental, social sustainability. Also, provides implications for consultants, practitioners, academicians.

Language: Английский

Citations

10