Ex-situ ChloGen: A facile and straightforward entry to Aryl-IF4 compounds DOI
Karim Ullah, Reza Kordnezhadian, Joachim Demaerel

et al.

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 110276 - 110276

Published: March 27, 2024

Language: Английский

Advances in Continuous Flow Fluorination Reactions DOI

Tsz Chun Lee,

Yi Tong,

Wai Chung Fu

et al.

Chemistry - An Asian Journal, Journal Year: 2023, Volume and Issue: 18(21)

Published: Sept. 14, 2023

Fluorination reactions are important in constructing organofluorine motifs, which contribute to favorable biological properties pharmaceuticals and agrochemicals. However, fluorination reagents associated with various problems, such as their hazardous nature, high exothermicity, poor selectivity scalability. Continuous flow has emerged a transformative technology provide many advantages relative batch syntheses. This review article summarizes recent continuous techniques that address the limitations challenges of reactions. Approaches based on different discussed, including gas-liquid reactions, packed-bed reactors, in-line purifications, streamlined multistep synthesis, large-scale well photoredox- electrocatalysis.

Language: Английский

Citations

6
Electrochemical oxidative cyclization of N-allylcarboxamides: efficient synthesis of halogenated oxazolines DOI

Yanyang He,

Yanzhao Yin,

Chenwei Liu

et al.

New Journal of Chemistry, Journal Year: 2021, Volume and Issue: 46(2), P. 663 - 667

Published: Dec. 1, 2021

Herein, we reported an efficient and sustainable intramolecular electrochemical cyclization of N -allylcarboxamides for the synthesis various halogenated oxazolines.

Language: Английский

Citations

13
Para‐Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes DOI

Michael Berger,

Marola S. Lenhard,

Siegfried R. Waldvogel

et al.

Chemistry - A European Journal, Journal Year: 2022, Volume and Issue: 28(41)

Published: May 5, 2022

The para-selective fluorination reaction of anilides using electrochemically generated hypervalent ArIF

Language: Английский

Citations

10
Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation DOI Creative Commons
Julian Spils, Thomas Wirth, Boris J. Nachtsheim

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 19, P. 27 - 32

Published: Jan. 3, 2023

We describe a multi-step continuous-flow procedure for the generation of six-membered diaryliodonium salts. The accompanying scalability and atom economy are significant improvements to existing batch methods. Benzyl acetates submitted this two-step as highly available cheap starting materials. An acid-catalyzed Friedel-Crafts alkylation followed by an anodic oxidative cyclization yielded defined set cyclic iodonium salts in substrate-dependent yield.

Language: Английский

Citations

5
Ex-situ ChloGen: A facile and straightforward entry to Aryl-IF4 compounds DOI
Karim Ullah, Reza Kordnezhadian, Joachim Demaerel

et al.

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 110276 - 110276

Published: March 27, 2024

Language: Английский

Citations

1