The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Herein,
a
cobalt-catalyzed
intramolecular
enantioselective
reductive
Heck
reaction
is
disclosed.
Starting
from
N-ortho-iodoaryl-2-(trifluoromethyl)acrylamides,
plethora
of
chiral
oxindoles
bearing
trifluoromethylated
quaternary
stereogenic
centers
at
the
C3-position
are
achieved
in
moderate
to
good
yields
(up
88%
yield)
and
excellent
enantioselectivities
94%
ee)
by
employing
zinc/silane
as
reducing
agent.
Other
than
trifluoromethyl
group,
number
alkyl,
aryl,
ester
groups
were
also
obtained
albeit
relatively
lower
(68–78%
ee).
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(20), P. 3191 - 3198
Published: July 3, 2024
Abstract
A
silver-catalyzed
dearomative
decarboxylative
[3+2]
spiroannulation
of
aryl
oxamic
acids
with
alkynes
is
described.
The
reaction
provides
reliable
access
to
a
range
azaspiro[4,5]trienones
in
moderate
yields
aqueous
media.
In
addition,
the
exhibits
broad
substrate
scope
and
good
functional
group
compatibility.
An
expedient
C–H
activation
strategy
for
the
assembly
of
indolo[1,2-
f
]phenanthridine
derivatives
via
a
Pd-catalyzed
decarboxylation
tandem
cyclization
is
presented.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(45), P. 9631 - 9636
Published: Nov. 4, 2024
An
efficient
copper-catalyzed
dearomative
[3
+
2]
annulation
of
indoles
with
2-iodoacetic
acid
is
developed.
By
employing
Cu(OTf)2/2,2′-bis(2-oxazoline)
as
the
catalyst
and
LPO
oxidant,
a
series
indoline-fused
butyrolactones
were
synthesized
in
moderate
to
good
yields.
The
reaction
features
mild
conditions,
broad
substrate
scope,
readily
available
starting
materials.
Furthermore,
synthetic
transformations
products
conducted
demonstrate
practical
utility
this
reaction.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Herein,
a
cobalt-catalyzed
intramolecular
enantioselective
reductive
Heck
reaction
is
disclosed.
Starting
from
N-ortho-iodoaryl-2-(trifluoromethyl)acrylamides,
plethora
of
chiral
oxindoles
bearing
trifluoromethylated
quaternary
stereogenic
centers
at
the
C3-position
are
achieved
in
moderate
to
good
yields
(up
88%
yield)
and
excellent
enantioselectivities
94%
ee)
by
employing
zinc/silane
as
reducing
agent.
Other
than
trifluoromethyl
group,
number
alkyl,
aryl,
ester
groups
were
also
obtained
albeit
relatively
lower
(68–78%
ee).
