Anisotropy in Antimicrobial Bottle Brush Copolymers and Its Influence on Biological Activity

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)

Published: Nov. 30, 2023

Abstract Antimicrobial polymers are a promising alternative to conventional antibiotics in the fight against antimicrobial resistance. Cationic bottle brush copolymers have shown be superior linear topologies previous studies. Herein, aspect ratio of such is varied creating differently shaped confined unimolecular structures with varying degrees side chain mobility. Using reversible addition‐fragmentation chain‐transfer (RAFT) polymerization, brushes produced one‐pot procedure. The morphology confirmed by atomic force microscopy. hydrophobicity, as determined via high performance‐liquid chromatography (HPLC) analysis, drastically influenced topology. Fourier‐transform infrared (FTIR) spectroscopy, it found that mobility and increased global hydrophilicity, less hydrated, stronger intramolecular hydrogen bonds. A phase segregated leading micellization assumed. Biological tests reveal activity for polymers. Their excellent hemocompatibility results highly selective whose adaptability seems key feature their performance. This study highlights tremendous importance structural control

Language: Английский

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Water-soluble polyphosphonate-based bottlebrush copolymers via aqueous ring-opening metathesis polymerization

Chemical Science, Journal Year: 2023, Volume and Issue: 14(40), P. 11273 - 11282

Published: Jan. 1, 2023

Ring-opening metathesis polymerization (ROMP) is a versatile method for synthesizing complex macromolecules from various functional monomers. In this work, we report the synthesis of water-soluble and degradable bottlebrush polymers, based on polyphosphoesters (PPEs) via ROMP. First, PPE-macromonomers were synthesized organocatalytic anionic ring-opening 2-ethyl-2-oxo-1,3,2-dioxaphospholane using N-(hydroxyethyl)-cis-5-norbornene-exo-2,3-dicarboximide as initiator 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) catalyst. The resulting norbornene-based macromonomers had degrees (DPn) ranging 25 to 243 narrow molar mass dispersity (Đ ≤ 1.10). Subsequently, these used in ROMP with Grubbs 3rd-generation bispyridyl (Ru-G3) produce library well-defined polymers. was carried out either dioxane or aqueous conditions, PPEs. Furthermore, two-step protocol employed synthesize double hydrophilic diblock copolymers water at neutral pH-values. This general enabled direct combination PPEs polymers block water. Degradation PPE side chains proven low degradation products only. biocompatible biodegradable nature makes pathway promising designing novel biomedical drug carriers viscosity modifiers, well many other potential applications.

Language: Английский

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Exploring conformations of comb-like polymers with varying grafting density in dilute solutions

The Journal of Chemical Physics, Journal Year: 2023, Volume and Issue: 159(11)

Published: Sept. 15, 2023

Comb-like polymers have shown potential as advanced materials for a diverse palette of applications due to the tunability their polymer architecture. To date, however, it still remains challenge understand how conformational properties these arise from interplay architectural parameters. In this work, extensive simulations were performed using dissipative particle dynamics investigate effect grafting density, backbone length, and sidechain length on conformations comb-like immersed in good solvent. quantify parameters conformations, we computed asphericity, radius gyration, end-to-end distances. Bond–bond correlation functions effective Kuhn lengths topological stiffness induced by sidechain–sidechain interactions. Simulation results reveal that increases density increase, agreement with previous experimental theoretical studies. This increase adopting extended increase. regarding gyration function are compared scaling theory predictions based free energy proposed Morozova Lodge [ACS Macro Lett. 6, 1274–1279 (2017)] arguments Tang et al. [Macromolecules 55, 8668–8675 (2022)].

Language: Английский

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Worm-globule transition of amphiphilic pH-responsive heterografted bottlebrushes at air–water interface

Soft Matter, Journal Year: 2024, Volume and Issue: 20(6), P. 1224 - 1235

Published: Jan. 1, 2024

Heterografted bottlebrushes with hydrophobic and tertiary amine-containing side chains exhibit compression-induced worm-to-globule transitions on the water surface at acidic basic pH when mole fraction of amine is <0.5.

Language: Английский

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Loop to linear: exploring the impact of corona topology on the properties of self-assembled polymer nanoparticles

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(16), P. 1648 - 1659

Published: Jan. 1, 2024

Cyclic block copolymers with photo-cleavable linkers were prepared, allowing looped-to-linear corona transformations via UV-induced post-assembly modification, and showcasing their versatility as topology-tuned drug delivery systems.

Language: Английский

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