Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6105 - 6105
Published: Aug. 17, 2023
So
many
biological
functional
disorders
and
diseases,
such
as
atherosclerosis,
hypertension,
diabetes,
Alzheimer’s
disease,
well
cell
malignancy
are
closely
related
with
the
intracellular
viscosity.
A
safe
effective
viscosity
detecting
method
is
desired
by
biomedical
community.
Recently,
a
novel
near-infrared
fluorescent
probe
NI-VIS
twisting
intramolecular
charge
transfer
mechanism
was
developed.
The
capability
of
this
to
visualize
variation
in
cirrhotic
liver
tissues
map
micro
vivo
were
testified
using
an
experiment.
In
work,
properties
studied
detail
under
quantum
mechanical
method.
low
energy
barrier
among
different
conformations
indicated
occurrence
due
rotation
aryl
group
molecule
while
within
environment.
electronic
structure
analysis
on
revealed
electron
process
optical
excitation.
All
these
theoretical
results
could
provide
insights
into
understand
greater
depth
principles
build
highly
monitor
samples.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(8), P. 3436 - 3444
Published: Feb. 19, 2024
Cerebral
ischemia–reperfusion
injury
(CIRI),
a
cause
of
cerebral
dysfunction
during
infarction
treatment,
is
closely
associated
with
mitochondrial
viscosity
and
hydrogen
peroxide
(H2O2).
However,
the
accurate
measurement
H2O2
levels
in
CIRI
challenging
because
lack
sufficient
selectivity
blood–brain
barrier
(BBB)
penetration
existing
monitoring
tools
related
to
CIRI,
hampering
exploration
role
CIRI.
To
address
this
issue,
we
designed
an
activatable
fluorescent
probe,
mitochondria-targeting
styryl-quinolin-ium
(Mito-IQS),
excellent
properties
including
high
selectivity,
targeting,
BBB
penetration,
for
visualization
brain.
Based
on
real-time
capabilities
bursts
were
visualized
This
probe
can
be
used
monitor
therapeutic
effects
butylphthalein
treatment.
More
importantly,
vivo
experiments
further
confirmed
that
was
levels.
discovery
provides
new
insights
study
expected
accelerate
process
diagnosis,
drug
design.
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(17), P. 2594 - 2605
Published: Aug. 20, 2024
ConspectusHepatic
ischemia-reperfusion
injury
(HIRI)
is
an
inevitable
complication
of
clinical
surgeries
such
as
liver
resection
or
transplantation,
often
resulting
in
postoperative
dysfunction,
hepatic
failure
up
to
13%
postresection
patients,
and
early
graft
11-18%
transplantation
patients.
HIRI
involves
a
series
biochemical
events
triggered
by
abnormal
alterations
multiple
biomarkers,
characterized
short
lifespans,
dynamic
changes,
subcellular
regional
distribution,
multicollaborative
regulation.
However,
traditional
diagnosis,
including
serology,
imaging,
puncture
biopsy,
suffers
from
low
sensitivity,
poor
resolution,
hysteresis,
which
hinder
effective
monitoring
markers.
Thus,
address
the
unique
properties
markers,
there
pressing
demand
for
developing
novel
detection
strategies
that
are
highly
selective,
transiently
responsive,
dynamically
reversible,
organelle-targeted,
capable
simultaneous
multicomponent
analysis.Optical
probe-based
fluorescence
imaging
powerful
tool
real-time
biomarkers
with
advantages
high
noninvasiveness,
rapid
analysis,
high-fidelity
acquisition
spatiotemporal
information
on
signaling
molecules
compared
conventional
methods.
Moreover,
growing
continuous
probes
reversible
features
receiving
more
attention.
Importantly,
can
not
only
monitor
fluctuations
marker
concentrations
but
also
distinguish
between
transient
bursts
markers
during
physiological
long-term
sustained
increases
pathological
levels.
This
effectively
avoid
false-positive
test
results,
addition,
be
reutilized
green
economical
features.
Therefore,
our
team
has
employed
various
methods
design
optical
HIRI.
We
proposed
recognition
based
specific
reactions
interactions
detect
changes
Given
biomarkers'
organelles
synergistic
regulatory
HIRI,
bifunctional
exploited,
organelle-targeted
detection.
With
these
strategies,
we
have
tailored
variety
fluorescent
reactive
oxygen/nitrogen
species
(O
Chemical & Biomedical Imaging,
Journal Year:
2023,
Volume and Issue:
2(2), P. 126 - 134
Published: Aug. 16, 2023
The
abnormal
microenvironment
parameter,
viscosity,
is
closely
connected
with
various
diffusion
processes,
signal
transduction,
molecule
interactions,
and
diseases.
It
greatly
significant
to
design
viscosity-dependent
near-infrared
(NIR)
small
fluorescence
probes
for
visualizing
biological
processes
or
diagnosing
Herein,
through
the
stepwise
modulating
structure
of
silicon–rhodamine
fluorophore
(SR),
we
report
three
viscosity
allyl
methyl
group
as
rotors,
named
SR-T-Al,
SR-S-Al,
SR-T-Me.
Among
them,
SR-T-Al
demonstrates
better
responsibility
from
1.0
1410.4
cP
viscosity.
Therefore,
probe
successfully
applied
sensitively
monitor
lysosome
microscopic
changes
living
cells
induced
by
oxygen
stress.
What's
more,
based
on
its
advantages
in
NIR
emission
(669
nm)
large
Stokes
shift
(201
nm),
also
use
it
image
variations
an
acute
hepatitis
mouse
carbon
tetrachloride.
Both
time
concentration-dependent
induction
models
display
great
ability
detect
alteration.
All
experimental
results
indicated
that
this
allyl-rotor-based
could
provide
a
general
platform
physiological
diseases
relating
