Published: Nov. 15, 2024
Language: Английский
ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(1), P. 011601 - 011601
Published: March 1, 2024
There is a plethora of electrochemical biosensors developed for ultrasensitive detection clinically relevant biomarkers. However, many these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting commercial success. Integration with sample processing technology addresses both challenges; however, it adds manufacturing complexity overall cost systems. Herein, we review different components biosensor avenues creating fully integrated In context integration, focus on discussing trade-offs between sensing performance, cost, scalable guide readers toward designing new commercialization potential.
Language: Английский
Citations
38
Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 13, 2025
Early and precise diagnosis of cancer is pivotal for effective therapeutic intervention. Traditional diagnostic methods, despite their reliability, often face limitations such as invasiveness, high costs, labor-intensive procedures, extended processing times, reduced sensitivity early-stage detection. Electrochemical biosensing a revolutionary method that provides rapid, cost-effective, highly sensitive detection biomarkers. This review discusses the use electrochemical in biosensors to provide real-time insights into disease-specific molecular interactions, focusing on target recognition signal generation mechanisms. Furthermore, superior efficacy compared conventional techniques explored, particularly ability detect biomarkers with enhanced specificity sensitivity. Advancements electrode materials nanostructured designs, integrating nanotechnology, microfluidics, artificial intelligence, have potential overcome biological interferences scale clinical use. Research innovation oncology diagnostics hold personalized medicine, challenges commercial viability real-world application.
Language: Английский
Citations
2
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 164, P. 112409 - 112409
Published: April 12, 2024
Language: Английский
Citations
15
Sensors, Journal Year: 2024, Volume and Issue: 24(9), P. 2904 - 2904
Published: May 1, 2024
Demand is strong for sensitive, reliable, and cost-effective diagnostic tools cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising platforms based on wide-ranging biomarkers owing to the versatility, high sensitivity, flexibility perform multiplexing of beads. This comprehensive review highlights trends innovations development cancer-biomarker We introduce various types such optical, electrochemical, magnetic biosensors, along with their respective advantages limitations. Moreover, summarizes latest advancements, including fabrication techniques, signal-amplification strategies, integration microfluidics nanotechnology. Additionally, challenges future perspectives field detection are discussed. Understanding these can greatly contribute improvements diagnostics, thereby facilitating early personalized treatments.
Language: Английский
Citations
9
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 249, P. 116030 - 116030
Published: Jan. 12, 2024
Language: Английский
Citations
7
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105983 - 105983
Published: July 20, 2024
Citations
7
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 258, P. 116372 - 116372
Published: May 9, 2024
Language: Английский
Citations
6
Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 231, P. 113559 - 113559
Published: Sept. 18, 2023
Language: Английский
Citations
16
International Journal of Electrochemical Science, Journal Year: 2023, Volume and Issue: 18(12), P. 100395 - 100395
Published: Nov. 1, 2023
Peptides have attracted great interest in the construction of electrochemical biosensors fields biomedicine, disease diagnosis, and environmental monitoring. They exhibit advantages high affinity specificity, chemical diversity building block amino acids, standard synthesis scheme. Versatile peptide-based been developed for detection various targets, including metal ions, enzymes, proteins, exosomes, cells, bacteria. their self-assembled nanostructures can be used as recognition elements, enzyme substrates, electrode materials, signal labels. Different functional species, electroactive small molecules, nanomaterials coupled with peptides direct conversion binding/modification events into measurable signals. Herein, we systematically summarize progress according to difference peptide function target type. The peptide-functionalized molecules amplification strategies improving sensitivity were discussed.
Language: Английский
Citations
16
Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(30), P. 7225 - 7247
Published: April 19, 2024
Abstract Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due fouling or receptor stability issues, the limitations determining toxic and small analytes, use, conditioned commercial availability of receptors exploration natural molecular interactions, deserved be highlighted. To address these challenges, addition intrinsic properties electrochemical biosensing, coupling with biomimetic materials has played a fundamental role, among which bioinspired phage peptide probes stand out. The versatility design employment opened an unimaginable plethora possibilities improving their far beyond development highly sensitive selective devices. state art offers robust electroanalytical biotools, capable operating samples exciting opportunities discover determine targets regardless toxicity size, bioreceptors, prior knowledge interactions. With all this mind, review panoramic, novel, updated vision both tremendous advances offered by combination biosensors challenges efforts are envisioned immediate future. Graphical
Language: Английский
Citations
4