Highly Efficient Transfer Dehydrogenative Oxidation of Secondary Alcohols to Ketones Catalyzed by Nn-Manganese Complexes DOI
Zheng Wang,

Xiaochi Lu,

Zhihui Li

et al.

Published: Jan. 1, 2023

Two types of non-phosphine based manganese(I) complexes, NN-manganese carbonyl complexes (Mn1 – Mn5) and NNN/S-pincer (Mn6 Mn10), have been assessed as catalysts for the transfer dehydrogenative oxidation secondary alcohols to afford ketones. Among them, Mn1, in combination with KBH4, proved most effective robust catalyst allowing (hetero)aromatic-, cycloalkyl aliphatic--containing be efficiently converted their corresponding ketones particularly high values TON achievable (TON up 2550). Furthermore, on basis experimental DFT studies, an outer-sphere bifunctional mechanism this Mn-catalyzed TDH is proposed. computations suggest that NN-bidentate complex Mn1 outperforms its tridentate NNN-Mn analogues due configuration steric hindrance catalysts. More importantly, Mn-based catalytic protocol using acetone inexpensive hydrogen acceptor offers attractive sustainable alternative producing aromatic aliphatic

Language: Английский

Highly efficient transfer dehydrogenative oxidation of secondary alcohols to ketones catalyzed by NN-manganese complexes DOI
Zheng Wang,

Xiaochi Lu,

Zhihui Li

et al.

Journal of Catalysis, Journal Year: 2024, Volume and Issue: 430, P. 115337 - 115337

Published: Feb. 1, 2024

Language: Английский

Citations

9
Biological Activities of Ruthenium NHC Complexes: An Update DOI Creative Commons
Alessia Catalano, Annaluisa Mariconda, Maria Stefania Sinicropi

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 365 - 365

Published: Feb. 9, 2023

Ruthenium N-heterocyclic carbene (NHC) complexes have unique physico-chemical properties as catalysts and a huge potential in medicinal chemistry pharmacology, exhibiting variety of notable biological activities. In this review, the most recent studies on ruthenium NHC are summarized, focusing specifically antimicrobial antiproliferative generally active against Gram-positive bacteria, such Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Listeria monocytogenes seldom Gram-negative including Salmonella typhimurium, Pseudomonas aeruginosa Escherichia coli fungal strains Candida albicans. The activity was tested cancer cell lines human colon, breast, cervix, epidermis, liver rat glioblastoma lines. demonstrated cytotoxicity higher than standard anticancer drugs. Further needed to explore mechanism action these interesting compounds.

Language: Английский

Citations

13
Synthesis and Characterisation of a Heterobimetallic N-heterocyclic Carbene Rhodium Ruthenium Complex as Catalyst for Transfer Hydrogenation DOI
Mohammad Kaikhosravi, Alexander D. Böth,

Michael J. Sauer

et al.

Journal of Organometallic Chemistry, Journal Year: 2022, Volume and Issue: 979, P. 122498 - 122498

Published: Aug. 31, 2022

Language: Английский

Citations

6
Cyclometalated C^N diphosphine ruthenium catalysts for Oppenauer-type oxidation/transfer hydrogenation reactions and cytotoxic activity DOI Creative Commons
Dario Alessi, Pierfrancesco Del Mestre, Eleonora Aneggi

et al.

Catalysis Science & Technology, Journal Year: 2023, Volume and Issue: 13(18), P. 5267 - 5279

Published: Jan. 1, 2023

The neutral ruthenium cyclometalated complexes [Ru(C^N)(η 2 -OAc)(dppb)] proven to be efficient catalysts in Oppenauer-type oxidation and transfer hydrogenation reactions with TOF up 14 300 h −1 show cytotoxic activity against U87 cancer cells.

Language: Английский

Citations

2
Piano‐stool dinuclear ruthenium (II) complexes of pyrazine‐carboxylate/carboxamide ligands: Structural studies and catalytic transfer hydrogenation of ketones DOI Creative Commons
Robert T. Kumah, Stephen O. Ojwach

Applied Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 37(11)

Published: Sept. 26, 2023

Reactions of ligand pyrazine‐2‐carboxylic acid ( HL1 ) with [Ru(η 6 ‐ p ‐cymene)Cl 2 ] precursor gave the dinuclear piano‐stool ruthenium (II) complex [{Ru(η }‐μ‐( L1 )‐{Ru( ‐cymene)Cl}] Ru1 ). Separately, reactions N‐ (quinolin‐8‐yl) pyrazine‐2‐carboxamide HL2 ), 5‐methyl‐ N ‐(−(quinolin‐8‐yl) pyridine‐2‐carboxamide HL3 and 5‐chloro‐ ‐(quinolin‐8‐yl) HL4 dimer in presence KPF afforded cationic complexes ‐cymene)Cl} ‐μ‐( L2 )][PF Ru2 L3 )][Ru( )Cl 3 Ru3 L4 Ru4 The Ru were analysed using FT‐IR, 1 H, 13 C{ H}, 31 P{ H} 19 F NMR spectroscopic techniques, micro‐analyses mass spectrometry. Molecular structures confirmed to display coordination nature single‐crystal X‐ray crystallography analyses. All Ru1–Ru4 mediated transfer hydrogenation (TH) a broad spectrum ketones isopropanol base demonstrated high catalytic activities (TON 24,000) at catalyst concentrations 0.002 mol%. In general, performance these depended on identity ligands, chemistry ketone substrates.

Language: Английский

Citations

2
Bidentate Ru(II)‐NC Complexes as Catalysts for Transfer Hydrogenation of Ketones with Ethanol DOI
Yufei Li, Shuang Lian, Jiku Wang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(3)

Published: Jan. 24, 2024

Abstract In this study, we developed a bidentate Ru(II) ‐ NC‐catalyzed transfer hydrogen reaction of ketones using ethanol (EtOH) as the source under weak base conditions. The control experiments suggested that proceeded via Ru‐H mechanism, yielding ethyl acetate only byproduct. deuterium‐labeling showed evolved from CH 2 and OH groups. These results provide new system for EtOH donor.

Language: Английский

Citations

0
Ru(II) complexes with phosphine-functionalized NHC ligands in catalytic transfer hydrogenations DOI

Johannes Mayr,

Robert M. Reich, Fritz E. Kühn

et al.

Advances in organometallic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 135 - 156

Published: Jan. 1, 2023

Language: Английский

Citations

0
Synthesis, crystallographic structure, theoretical analysis, molecular docking studies, electronic properties and biological activity evaluation of ruthenium-complex bearing N-heterocyclic carbene ligand DOI
Ichraf Slimani, Nasser Amri, Yousef E. Mukhrish

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(24), P. 11708 - 11722

Published: Jan. 1, 2023

The development of new classes antimicrobials is urgently needed due to the widespread occurrence multi-resistant pathogens.

Language: Английский

Citations

0
Highly Efficient Transfer Dehydrogenative Oxidation of Secondary Alcohols to Ketones Catalyzed by Nn-Manganese Complexes DOI
Zheng Wang,

Xiaochi Lu,

Zhihui Li

et al.

Published: Jan. 1, 2023

Two types of non-phosphine based manganese(I) complexes, NN-manganese carbonyl complexes (Mn1 – Mn5) and NNN/S-pincer (Mn6 Mn10), have been assessed as catalysts for the transfer dehydrogenative oxidation secondary alcohols to afford ketones. Among them, Mn1, in combination with KBH4, proved most effective robust catalyst allowing (hetero)aromatic-, cycloalkyl aliphatic--containing be efficiently converted their corresponding ketones particularly high values TON achievable (TON up 2550). Furthermore, on basis experimental DFT studies, an outer-sphere bifunctional mechanism this Mn-catalyzed TDH is proposed. computations suggest that NN-bidentate complex Mn1 outperforms its tridentate NNN-Mn analogues due configuration steric hindrance catalysts. More importantly, Mn-based catalytic protocol using acetone inexpensive hydrogen acceptor offers attractive sustainable alternative producing aromatic aliphatic

Language: Английский

Citations

0