Nanobiotechnology Reports, Journal Year: 2024, Volume and Issue: 19(5), P. 645 - 666
Published: Oct. 1, 2024
Language: Английский
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105865 - 105865
Published: Jan. 1, 2025
Language: Английский
Citations
1
Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 813 - 813
Published: Feb. 26, 2025
Emerging evidence links depressive disorders to the gut microbiota via gut-brain axis. Probiotics, which are microorganisms that modulate microbiota, have shown promising results in alleviating depression and increasingly recognized as functional food components with potential health benefits. This study examines effects of Lactiplantibacillus plantarum GOLDGUT-HNU082 (Lp082), a probiotic strain applications foods, on chronic unpredictable mild stress (CUMS)-induced mice. Behavioral tests, measurements neurotransmitters inflammatory cytokines serum colon tissue, metagenomic sequencing were used investigate mechanisms. The demonstrated Lp082 significantly alleviated depressive-like behaviors CUMS mice, restored balance key like serotonin (5-HT), reduced levels TNF-α, enhanced brain neuroplasticity by promoting hippocampal neurogenesis. Additionally, altered composition mice promoted growth Bifidobacterium, improving metabolic pathways related neurotransmitter synthesis. These findings indicate Lp082, ingredient, alleviates reshaping offering new insights into use probiotics foods for mental management.
Language: Английский
Citations
1
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 211 - 221
Published: May 3, 2024
Neuroinflammation is involved in the advancement of depression. Du-moxibustion can treat Here, we explored whether could alleviate neuroglia-associated neuro-inflammatory process chronic unpredictable mild stress (CUMS) mice.
Language: Английский
Citations
5
Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 101020 - 101020
Published: Jan. 1, 2025
Depression is a mental disorder, and genistein known to have antidepressant effects, but its mechanism of action still unclear. Here, the improving depression based on gut microbiota was explored using classic behavioral indicators combined with genomic technology. The evaluation showed that rats gavaged 20-40 mg/kg an increase in body weight, glucose preference, absenteeism score, temperature, 5-hydroxytryptamine (5-HT) content, while decrease adrenocorticotropic hormone (ACTH) corticosterone (CORT) content compared rat model group, there no significant difference positive control (fluoxetine). results high-throughput sequencing increased relative abundance Firmicutes Actinobacteriota decreased Bacteroidota at phylum level. At genus level, Bifidobacterium, short-chain fatty acid producing bacterium, increased. Furthermore, metagenome revealed effect can be achieved by promoting glutamate metabolism, increasing glutamic decarboxylase (GAD) expression levels, γ-aminobutyric (GABA) synthesis, indirectly 5-HT levels.
Language: Английский
Citations
0
Anesthesiology and Perioperative Science, Journal Year: 2025, Volume and Issue: 3(2)
Published: May 7, 2025
Abstract Purpose The present study aims to evaluate the effects of electroconvulsive therapy (ECT) on depressive behaviors. In addition, we explore mechanisms by which ECT alters composition and functioning gut microbiota through microbiota-gut-brain axis. Methods A depression model in mice was established using chronic unpredictable mild stress. were divided into three groups: control, depression, ECT-treated. Depressive behaviors assessed a series behavioral tests, including monitoring body weight, open field sucrose preference forced swim tests. Histological microcirculatory assessments brain tissues conducted hematoxylin eosin (H&E) staining, Nissl staining immunofluorescence methodology along with laser speckle contrast imaging. inflammatory cytokines Tumor Necrosis Factor- α (TNF- ), Interleukin-6 (IL-6) Interleukin-1 β (IL-1 ) quantified enzyme-linked immunosorbent assay. Metagenomic sequencing employed diversity abundance microbiota. Results significantly improved as evidenced increased weight decreased immobility time H&E indicated substantial reduction inflammation while revealed restoration neuronal morphology following treatment. Furthermore, analysis showed elevated c-Fos expression hippocampal region ( P < 0.05). Assessments demonstrated significant reductions TNF- , IL-6, IL-1 levels group. metagenomic that enhanced diversity, particularly restoring Bacteroides Verrucomicrobia Conclusion exerts its antidepressant modulating enhancing functionality gut-brain
Language: Английский
Citations
0
Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2154 - 2154
Published: July 8, 2024
Alzheimer's disease (AD) is a common neurological with recognition ability loss symptoms and major contributor to dementia cases worldwide.
Language: Английский
Citations
2
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(46), P. 25675 - 25689
Published: Nov. 6, 2024
Casein hydrolysates have been proven to exert varying sleep-enhancing and anxiolytic effects due their distinct release of potential peptides. However, underlying mechanisms at the metabolic level remain unclear. This study aims investigate mechanism casein through an integrated approach untargeted targeted metabolomics in CUMS-induced anxiety mice for first time. The results showed seven biomarkers were identified screened using orthogonal partial least-squares discriminant analysis, random forest model, pathway including ornithine, l-proline, l-prolinamide, inhibitory neurotransmitters gamma-aminobutyric acid, 5-HIAA, fumaric 4-oxoglutaramate. Moreover, exerted multiple pathways, mainly GABAergic system, tryptophan metabolism, cAMP response signaling pathway, which was validated by vital protein expressions. It interesting that with diverse representative peptide compositions exhibited activity, could be attributed alterations metabolites via different pathways.
Language: Английский
Citations
1
Food & Function, Journal Year: 2023, Volume and Issue: 14(18), P. 8409 - 8419
Published: Jan. 1, 2023
Background: Depression is a psychiatric disorder with depressed mood and even suicide attempts as the main clinical symptoms, its pathogenesis has not yet been fully elucidated. Brain derived neurotrophic factor (BDNF) plays an important role in of depression. Purpose: The aim present study was to evaluate effectiveness reveal potential mechanisms bilobalide (BB) intervention alleviating depression-like behaviors by using chronic unpredictable mild stress (CUMS) mice via mediating BDNF pathway. Methods: Behavioral assessments were carried out sucrose preference test (SPT), tail suspension (TST), forced swimming (FST). CUMS randomly divided into 5 groups: + solvent, BB low, medium, high fluoxetine. Total serum levels tumor necrosis (TNF-α) interleukin-6 (IL-6) measured ELISA. Expression TNF-α, IL-6, AKT, GSK3β, β-catenin, Trk-B mouse hippocampus assessed western blotting. Results: treatment reduced pro-inflammatory cytokines (IL-6 TNF-α) increased protein expression region mice. Moreover, enhanced AKT/GSK3β/β-catenin signaling pathway which downstream receptor these Conclusions: Overall, experimental results indicated that reverses CUMS-induced behavior. exerts antidepressant-like effects inhibiting neuroinflammation enhancing function factors.
Language: Английский
Citations
3
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(1)
Published: Dec. 18, 2023
Brain injury in preterm infants potentially disrupts critical structural and functional connective networks the brain. It is a major cause of neurological sequelae developmental deficits infants. Interesting findings suggest that gut microbiota (GM) their metabolites contribute to programming central nervous system (CNS) during stages may exert effects throughout lifespan.
Language: Английский
Citations
3
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 7, 2024
Abstract Background Depression and insomnia often co-occur have a bidirectional relationship. This review utilized bibliometric visualized analysis to explore current research hotspots trends in this field identify future clinical practice directions. Methods To papers on the comorbidity of depression insomnia, researchers Web Science Core Collection (WoSCC). They employed tools such as CiteSpace, VOSviewer, Scimago Graphica visually analyze knowledge network authors, institutions, countries/regions, journals, cited references, keywords comorbid with insomnia. Results A total 697 were extracted from (WoSCC) Andrew D. Krystal being most influential author area. The University Pittsburgh United States emerged prolific institution country, respectively. Journal Affective Disorders was productive journal, primary including depression, anxiety, disorder, sleep. In terms co-citation analysis, Morin, Cm led field. top-cited journal Sleep, paper titled “Validation Insomnia Severity Index an outcome measure for research” ranked first. Finally, “Psychiatry”was frequent study category. Conclusions provides comprehensive overview highlights key areas focus, offering guidance clinicians selecting
Language: Английский
Citations
0