ARKIVOC,
Journal Year:
2022,
Volume and Issue:
2022(3), P. 133 - 161
Published: July 9, 2022
Organophosphorus
chemistry
is
an
exciting
field
of
research.Phosphorus-functionalized
organic
molecules
find
practical
and
useful
applications
in
such
diverse
areas
as
medicinal,
pharmaceutical,
agrochemical,
materials
chemistries,
both
on
laboratory
industrial
scales.Green-chemistry
principles
are
motivating
the
design
development
newer
synthetic
methodologies
for
beneficial
organophosphorus
compounds
their
analogues.Solvent-free
conditions
associated
with
several
benefits,
including
operational
simplicity,
cost-effectiveness,
minimization
waste
generation,
reduced
pollution,
all
which
very
much
crucial
process
development.This
review
summarizes
solvent-free
functionalized
reported
during
period
2016
through
2021.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 1, 2025
Abstract
1,4‐Naphthoquinones
(1,4‐NQs)
are
an
important
class
of
molecules
with
diverse
pharmaceutical
applications.
Lawsone,
a
naturally
occurring
molecule
range
bioactivities,
falls
in
the
1,4‐NQs.
It
possesses
1,3‐dicarbonyl
functionality,
which
has
been
utilized
synthesis
bis‐lawsones
reaction
aldehydes.
In
this
review
we
have
discussed
notable
developments
bis‐lawsone
from
2009
to
2023.
Also,
highlights
limitations
and
future
perspectives
area.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(2), P. 1049 - 1060
Published: Jan. 4, 2023
A
straightforward
and
efficient
electrochemical
method
for
regioselective
C(sp2)-H
selenylation
sulfenylation
of
substituted
2-amino-1,4-naphthoquinones
has
been
unearthed.
This
oxidative
cross-coupling
reaction
avoids
using
transition
metal
catalysts,
oxidants,
high
temperatures.
The
other
notable
advantages
this
protocol
are
the
tolerance
diverse
functional
groups,
mild
conditions
at
ambient
temperature,
energy
efficiency,
good
to
excellent
yields,
short
times
(in
minutes),
gram-scale
applicability,
eco-friendliness.
New Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
46(28), P. 13483 - 13497
Published: Jan. 1, 2022
The
essence
of
photo-
and
electrochemistry:
sulfenylation
selenylation
substituted
benzo[
a
]phenazin-5-ols
through
cross-dehydrogenative
C(sp
2
)–H
functionalization.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1645 - 1655
Published: Jan. 17, 2025
We
present
a
novel,
metal-
and
additive-free
method
for
the
robust
synthesis
of
dihydrofuran-fused
naphthalenes
coumarins.
This
approach
utilizes
annulative
coupling
sulfoxonium
ylides
with
aldehydes,
naphthols,
or
coumarins
at
ambient
temperature.
The
exhibits
broad
substrate
compatibility,
accommodating
various
functional
groups
on
naphthol
coumarin
derivatives
resulting
in
good
to
high
yields
desired
products.
Additionally,
we
successfully
scaled
up
reactions,
synthesized
were
further
converted
other
valuable
bioactive
molecules,
validating
viability
our
approach.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(15)
Published: March 6, 2023
Abstract
An
efficient
and
straightforward
protocol
for
accessing
a
new
series
of
functionalized
4‐aminocoumarins
from
PIDA/I
2
‐mediated
decarboxylative
C
4
‐amination
coumarin‐3‐carboxylic
acids
via
direct
sp2
−H
dehydrogenative
C−N
cross‐coupling
with
secondary
amines
under
ambient
conditions
has
been
accomplished.
The
notable
advantages
this
are
the
tolerance
diverse
functional
groups,
mild
reaction
at
temperature,
moderate
to
good
yields,
short
times
(in
minutes),
high
regioselectivity,
gram‐scale
applicability,
eco‐friendliness.
This
is
first
report
cross‐dehydrogenative
coupling
synthesizing
4‐aminocoumarins.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(63)
Published: Sept. 4, 2023
A
mechanochemistry-driven
practical
and
efficient
synthetic
protocol
for
accessing
diverse
series
of
biologically
relevant
poly-functionalized
5-(arylselanyl)-1H-1,2,3-triazoles
through
copper(I)-catalyzed
click
reaction
between
aryl/heteroaryl
acetylenes,
diaryl
diselenides,
benzyl
bromides,
sodium
azide
has
been
accomplished
under
high-speed
ball-milling.
Advantages
this
method
include
operational
simplicity,
avoidance
using
solvent
external
heating,
one-pot
synthesis,
short
time
in
minutes,
good
to
excellent
yields,
broad
substrate
scope,
gram-scale
applications.
Furthermore,
synthesized
organoselenium
compounds
were
synthetically
diversified
promising
selenones.
Current Green Chemistry,
Journal Year:
2023,
Volume and Issue:
11(2), P. 210 - 220
Published: Oct. 16, 2023
Abstract:
An
ultrasound-assisted
catalyst-free
green
protocol
has
been
developed
for
the
synthesis
of
a
series
diversely
substituted
Knoevenagel
condensation
products
from
reaction
between
functionalized
aromatic
aldehydes/isatin
derivatives
and
malononitriles
as
C-H
acids
in
water
at
ambient
conditions.
The
method
is
simple,
straightforward,
highly
efficient.
major
advantages
this
newly
are
expedient
synthesis,
good
to
excellent
yields,
energy
efficiency,
use
medium,
easy
isolation
products,
no
need
column
chromatographic
purification,
eco-friendliness,
operational
simplicity.
Synthetic Communications,
Journal Year:
2023,
Volume and Issue:
53(11), P. 779 - 794
Published: April 7, 2023
AbstractAbstractEucalyptol
or
1,8-cineole,
a
bio-based
monoterpene,
whose
potential
has
been
explored
as
viable
alternative
reaction
media
for
the
development
of
several
heterocyclic
systems.
As
an
eco-benign
solvent
eucalyptol
found
to
be
promising,
bio-competent,
green
in
our
protocols
without
allowing
involvement
any
transition
metal
catalyst
at
suitable
temperature.
In
present
work,
we
carried
out
synthesis
2,3-dihydroquinazolin-4(1H)-one
and
isoxazolone
derivatives
from
aldehydes
by
using
this
unexplored
but
effective
solvent.
The
use
recyclable
helped
us
avoid
hazardous,
toxic,
harsh
conditions
toward
different
desired
systems.Graphical
AbstractKeywords:
2,3-Dihydroquinazolin-4(1H)-one
derivativeseco-viableeucalyptolisoxazolone
derivativesmild
AcknowledgmentsThe
authors
are
thankful
UGC,
New
Delhi.Disclosure
statementNo
conflict
interest
was
reported
author(s).
