Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides DOI Open Access

Zhefan Zhang,

Lingchao Cai, Liangliang Song

et al.

Processes, Journal Year: 2023, Volume and Issue: 11(8), P. 2262 - 2262

Published: July 27, 2023

Peptide modification has emerged as an important topic in the academic community and pharmaceutical industry. However, they are primarily focused on diversification of amines, thiols, alcohols. Direct chemoselective acid residues peptides is relatively underdeveloped. In this context, we report a novel efficient method for direct functionalization peptides. By using ynamides reaction partners, adducts rapidly obtained moderate to excellent yields at room temperature water. This approach shows chemoselectivity broad scope including dipeptides bearing unprotected Trp or Tyr residue free Ser Gln residue.

Language: Английский

Catalytic C–C Bond Forming Reaction to Imines DOI
Branislav Kokić, Ana Andrijević, Igor Opsenica

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
CuI-Zeolite Catalysis for Biaryl Synthesis via Homocoupling Reactions of Phenols or Aryl Boronic Acids DOI Creative Commons

Xiaohui Di,

Tony Garnier,

Arnaud Clerc

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5552 - 5552

Published: Nov. 25, 2024

Due to the importance of biaryls as natural products, drugs, agrochemicals, dyes, or organic electronic materials, a green alternative biaryl synthesis has been developed based on easy-to-prepare and cheap copper(I)-exchanged zeolite catalysts. CuI-USY proved efficiently catalyze direct homocoupling either phenols aryl boronic acids under simple practical conditions. The CuI-USY-catalyzed oxidative could conveniently be performed air in warm methanol water with good high yields. In methanol, small amount Cs2CO3 was required, while none necessary water. best also without an additive. These mild conditions showed functional-group tolerance, leading variety substituted (hetero)biaryls (28 examples). heterogeneous catalyst readily recovered reused. Interestingly, vinyl successfully coupled Diels–Alder reaction, even one-pot process, allowing access highly functionalized cyclohexenes.

Language: Английский

Citations

1
Copper-zeolites Prepared by Solid-state Ion Exchange - Characterization and Evaluation for the Direct Conversion of Methane to Methanol DOI Creative Commons
Karoline Kvande, Sebastian Prodinger, Fabian Schlimpen

et al.

Topics in Catalysis, Journal Year: 2022, Volume and Issue: 66(17-18), P. 1406 - 1417

Published: Dec. 27, 2022

Abstract Direct conversion of methane to methanol (MTM) over Cu-zeolites is a so-called “dream reaction” for the chemical industry. There still lot that can be done in order optimize reaction by e.g. achieving deeper understanding mechanism and nature Cu-sites. In this study, we investigated solid-state ion exchange method incorporate Cu I ions into zeolites (MOR, BEA, ZSM-5 FAU), as more scalable technique. The led Cu/Al ration about 0.8, however with heterogeneous distribution Cu. Regardless, Fourier transform-infrared spectroscopy revealed most Brønsted acid sites were exchanged all four samples. Further, CH 4 -temperature programmed experiments showed some Cu-sites formed reactive towards , -MOR -FAU having largest consumption. Ultimately, -zeolites tested MTM proved capable producing methanol, even without presence sites. A MOR lower ratio (0.30) was also comparison, sample obtained much higher productivity than high Cu-loading (0.10 vs. 0.03 mol MeOH /mol ), it demonstrated fine-tuning necessary obtain active activation.

Language: Английский

Citations

6
Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides DOI Open Access

Zhefan Zhang,

Lingchao Cai, Liangliang Song

et al.

Processes, Journal Year: 2023, Volume and Issue: 11(8), P. 2262 - 2262

Published: July 27, 2023

Peptide modification has emerged as an important topic in the academic community and pharmaceutical industry. However, they are primarily focused on diversification of amines, thiols, alcohols. Direct chemoselective acid residues peptides is relatively underdeveloped. In this context, we report a novel efficient method for direct functionalization peptides. By using ynamides reaction partners, adducts rapidly obtained moderate to excellent yields at room temperature water. This approach shows chemoselectivity broad scope including dipeptides bearing unprotected Trp or Tyr residue free Ser Gln residue.

Language: Английский

Citations

0