Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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Construction of multifunctional wound dressings with their application in chronic wound treatment

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(15), P. 4058 - 4076

Published: Jan. 1, 2022

Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.

Language: Английский

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Self‐Healing, Injectable Hydrogel Dressing for Monitoring and Therapy of Diabetic Wound

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: Feb. 28, 2024

Abstract Chronic diabetic wound repair is a global medical challenge. Developing hydrogel dressing to effectively promote angiogenesis and detect state in management an unmet requirement. Herein, facile efficient strategy prepare self‐healing with enhanced real‐time monitoring for wounds presented, by cross‐linking carboxymethyl cellulose (CMC) precoordinated europium‐ethylenediaminetetraacetic acid (Eu‐EDTA) complexes. Benefiting from the dynamic reversible coordination interaction formation, exhibits remarkable injectability properties, thus forming coverage irregular deep minimally invasive procedures. Furthermore, fluorescence of changes linearly pH value range 4.5–7.5 enables measurement monitor state. More importantly, can proliferation migration endothelial cells enhance tube formation ability, demonstrating great capacity tissue remodeling. The vivo experiments manifested that upregulating expression angiogenesis‐related factors downregulating matrix metalloproteinase‐9 (MMP‐9), contributing granulation collagen deposition, repair. This work provide promising diagnosis therapy clinical wounds.

Language: Английский

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Waste to Wealth: Near-Infrared/pH Dual-Responsive Copper-Humic Acid Hydrogel Films for Bacteria-Infected Cutaneous Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 17199 - 17216

Published: Aug. 25, 2023

The clinical applications of currently used photosensitizers are limited by high costs, inconvenient preparation, suboptimal biodegradability, and a lack biological activity. Humic acids (HAs) show photothermal activity can be as photosensitizer for therapy. In the presence various functional groups, HAs endowed with anti-inflammatory antioxidant activities. solubility is dependent on pH value, which soluble in neutral to alkaline conditions undergoes conformational change coiled compact structure acidic conditions. Additionally, Cu2+ an emerging therapeutic agent cutaneous wounds chelated form complexes. this study, we explore ability modulate inflammatory response, particularly macrophage polarization, potential underlying mechanism. We fabricate near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded SEW2871 (SEW), recruitment agent, treat bacteria-infected wounds. results that could promote M2 polarization dose-dependent manner. NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW improves tissue regeneration promoting alleviating oxidative stress, enhancing angiogenesis, facilitating collagen deposition. These findings highlight treatment bacterially infected wound healing.

Language: Английский

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Establishments and Evaluations of Post‐Operative Adhesion Animal Models

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(4)

Published: Feb. 4, 2023

Abstract After abdominopelvic surgery, there are 90–93% of patients who develop postoperative adhesions. Post‐operative adhesions can occur after various surgical procedures, which not only cause a series complications but also increase the economic burden patients. Based on US FDA rules, anti‐adhesive products need to be deeply evaluated for their bio‐functionality in animal models before clinic entrance. However, date, few literatures systematically summarizing establish approaches and evaluation standards post‐operative adhesion models. Therefore, according importance knowledge related vivo models, this manuscript, occurrence mechanism is reviewed, followed by construction methods at different organs, then common indicators including scores histological characterization listed. This review reference characterizations materials.

Language: Английский

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Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122014 - 122014

Published: March 4, 2024

Language: Английский

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Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 518 - 532

Published: March 12, 2024

Language: Английский

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First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(27)

Published: March 7, 2024

Abstract In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(ε‐caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution electrospun (SES) membrane at the dermoepidermal interface melt electrowritten (MEW) scaffold that provides an optimal open‐pore environment dermis. To knowledge, this is only one capable creating properly differentiated, full thickness with neosynthesized extracellular matrix (ECM) in 18 days. Both wavy straight fiber designs create well‐organized dermis, dermal collagen organization differs between designs. Adding cells vitamin C to scaffolds improves mechanical properties more closely mimic native human skin. These findings establish bicomponent as promising advancement rapidly different varied properties. versatility adaptability can be used studying how biological physical microenvironment impact skin, testing dermo‐cosmetics pharmaceutical treatments on ages Furthermore, it excellent new tool wound healing development into its use graft or dressing ongoing.

Language: Английский

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Advances in 3D skin bioprinting for wound healing and disease modeling

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 19, 2022

Abstract Even with many advances in design strategies over the past three decades, an enormous gap remains between existing tissue engineering skin and natural skin. Currently available vitro models still cannot replicate three-dimensionality heterogeneity of dermal microenvironment sufficiently to recapitulate known characteristics disorder or disease vivo. Three-dimensional (3D) bioprinting enables precise control multiple compositions, spatial distributions architectural complexity, therefore offering hope for filling structure function artificial Our understanding wound healing process would thus be boosted by development that could more completely capture heterogeneous features biology. Here, we provide overview recent 3D bioprinting, as well concepts cells bioinks suitable process. We focus on applications this technology physiological pathological model, focusing specifically appendages vasculature. conclude current challenges technical perspective further bioprinting.

Language: Английский

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Acceleration of wound healing by composite small intestinal submucosa hydrogels through immunomodulation

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 254, P. 110550 - 110550

Published: Jan. 21, 2023

Language: Английский

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