L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling DOI Creative Commons
Wenjing Jin, Ling Su, Hong You

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

Abstract Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and attentions reversing drug resistance. However, its lung chemoresistance still unknown. To investigate effects L-Theanine on explore underlying mechanism cancer, we performed panel experiments vitro combined with RNA-seq analysis demonstrated improved to cisplatin (cis-diamminedichloroplatinum; DDP) inhibited stemness DDP-resistant but not non-resistant STAT3/NOTCH1 signaling was potential dominant process involved improving cancer. Mechanistically, impedes migration activation via regulating expression STAT3/NOTCH1/BMAL1 signaling-induced markers, reducing proliferation as well inhibiting resistance-related genes cells. In addition, combination Stat3 blockade synergistically summary, chemoresistant through signaling, finally The finding might provide research evidence for therapeutic options

Language: Английский

L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling DOI Creative Commons
Wenjing Jin, Ling Su, Hong You

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 18, 2023

Abstract Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and attentions reversing drug resistance. However, its lung chemoresistance still unknown. To investigate effects L-Theanine on explore underlying mechanism cancer, we performed panel experiments vitro combined with RNA-seq analysis demonstrated improved to cisplatin (cis-diamminedichloroplatinum; DDP) inhibited stemness DDP-resistant but not non-resistant STAT3/NOTCH1 signaling was potential dominant process involved improving cancer. Mechanistically, impedes migration activation via regulating expression STAT3/NOTCH1/BMAL1 signaling-induced markers, reducing proliferation as well inhibiting resistance-related genes cells. In addition, combination Stat3 blockade synergistically summary, chemoresistant through signaling, finally The finding might provide research evidence for therapeutic options

Language: Английский

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