Mobile-assisted diagnostic biosensor for point-of-care glucose detection in real human samples with rapid response and long-live stability DOI Creative Commons
Artur Jędrzak,

Maria Kuznowicz,

Teofil Jesionowski

et al.

Journal of Applied Electrochemistry, Journal Year: 2023, Volume and Issue: 54(1), P. 163 - 174

Published: June 26, 2023

Abstract In this work, the β-cyclodextrins (βCD) grafted on magnetite@polynorepinephrine (Fe 3 O 4 @PNE) nanomaterial with glucose oxidase (GOx) from Aspergillus niger was presented. The electroactive nanoplatform used to construct rapid response and long-live time biosensor for qualitative quantitative determination. deposited screen-printed electrode (SPE) integrated potentiostat in tandem a portable devices. methodology may affect its relatively low unit cost, miniaturization aspect, system integrity. potential usage is intended advanced diabetes care focus point-of-care testing idea. cyclic voltammetry amperometry were electrochemical characterization. presented SPE/Fe @PNE@βCD-GOx enabled measurements wide range of concentrations (0.1–30.0 mM), an enhanced sensitivity (204.82 µA mM − 1 cm 2 ), limit detection (3.2 µM), (2.6 s). Moreover, proposed sensor achieved long-term stability, up 11 months. Testing real samples (human blood, human serum, infusion fluids) showed recovery 95.5 98.6%. outcomes demonstrated that has great use determining amount biological fluids commercial products. novelty work would largely consist possibility long stability. This enables mobile diagnostics tests including Due applied surface novel polynorepinephrine biopolymer coating, selectivity, improved. Graphical

Language: Английский

A Review on CNTs-Based Electrochemical Sensors and Biosensors: Unique Properties and Potential Applications DOI
Hicham Meskher,

Teqwa Ragdi,

Amrit Kumar Thakur

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 54(7), P. 2398 - 2421

Published: Feb. 1, 2023

Carbon nanotubes (CNTs), are safe, biocompatible, bioactive, and biodegradable materials, have sparked a lot of attention due to their unique characteristics in variety applications, including medical dye industries, paper manufacturing water purification. CNTs also strong film-forming potential, permitting them be widely employed constructing sensors biosensors. This review concentrates on the application CNT-based nanocomposites production electrochemical It emphasizes synthesis optimization for range applications outlines benefits using biomolecule immobilization. In addition, use molecularly imprinted polymer (MIP)-CNTs is discussed. The challenges faced by current CNTs-based sensors, along with some future perspectives opportunities, briefly explained this paper.

Language: Английский

Citations

117

Recent Progress in Micro- and Nanotechnology-Enabled Sensors for Biomedical and Environmental Challenges DOI Creative Commons
Francisco J. Tovar‐Lopez

Sensors, Journal Year: 2023, Volume and Issue: 23(12), P. 5406 - 5406

Published: June 7, 2023

Micro- and nanotechnology-enabled sensors have made remarkable advancements in the fields of biomedicine environment, enabling sensitive selective detection quantification diverse analytes. In biomedicine, these facilitated disease diagnosis, drug discovery, point-of-care devices. environmental monitoring, they played a crucial role assessing air, water, soil quality, as well ensured food safety. Despite notable progress, numerous challenges persist. This review article addresses recent developments micro- for biomedical challenges, focusing on enhancing basic sensing techniques through micro/nanotechnology. Additionally, it explores applications addressing current both domains. The concludes by emphasizing need further research to expand capabilities sensors/devices, enhance sensitivity selectivity, integrate wireless communication energy-harvesting technologies, optimize sample preparation, material selection, automated components sensor design, fabrication, characterization.

Language: Английский

Citations

82

The LOD paradox: When lower isn't always better in biosensor research and development DOI
Hichem Moulahoum, Faezeh Ghorbanizamani

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 264, P. 116670 - 116670

Published: Aug. 13, 2024

Language: Английский

Citations

24

Advancements in wearable sensors for cardiovascular disease detection for health monitoring DOI
Bangul Khan, Zainab Riaz, Rafi u Shan Ahmad

et al.

Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 159, P. 100804 - 100804

Published: May 21, 2024

Language: Английский

Citations

17

Aspects of Electrochemical Biosensors Using Affinity Assays DOI Creative Commons

Thor Pedersen,

Leonid Gurevich, Nils E. Magnusson

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 166 - 166

Published: March 4, 2025

In recent decades, the utilization of biomarkers has gained increasing attention. The timely identification and quantification proteins, nucleic acids, small molecules associated with a medical condition, infection, or contaminant have become increasingly crucial across variety fields, including medicine, food safety, quality/environmental control. State-of-the-art biomarker detection methods predominantly rely on standard immunoassay techniques, requiring specialized laboratory equipment trained personnel. This impedes broad commercial implementation biosensors in, e.g., Point-of-Care (PoC) settings where ease operation, portability, cost-efficiency are prioritized. Small, robust electrochemical promising alternative for analyzing in complex samples within PoC environments. Therefore, creating designing optimized sensing surfaces, immobilization strategies, efficient signal generation improving biosensor systems, which turn can real-world impact. present paper, we reviewed common electrode types geometries used approaches, discussed advantages drawbacks different methods, presented labeling strategies enhancement.

Language: Английский

Citations

2

Carbon nanotube-based biocompatible polymer nanocomposites as an emerging tool for biomedical applications DOI
Rakshit Pathak, Vinay Deep Punetha, Shalini Bhatt

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 196, P. 112257 - 112257

Published: June 24, 2023

Language: Английский

Citations

40

Mini review about metal organic framework (MOF)-based wearable sensors: Challenges and prospects DOI Creative Commons
Hicham Meskher, Samir Brahim Belhaouari, Fariborz Sharifianjazi

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21621 - e21621

Published: Oct. 27, 2023

Among many types of wearable sensors, MOFs-based sensors have recently been explored in both commercialization and research. There has much effort various aspects the development MOF-based including but not limited to miniaturization, size control, safety, improvements conformal flexible features, analytical performance long-term storage these devices. Recent progress design deployment are covered this paper, as remaining obstacles prospects. This work also highlights enormous potential for synergistic effects MOFs used combination with other nanomaterials healthcare applications raise attention toward economic aspect market diffusion sensors.

Language: Английский

Citations

33

A Magnetite Composite of Molecularly Imprinted Polymer and Reduced Graphene Oxide for Sensitive and Selective Electrochemical Detection of Catechol in Water and Milk Samples: An Artificial Neural Network (ANN) Application DOI Creative Commons
Hicham Meskher, Samir Brahim Belhaouari, Kalim Deshmukh

et al.

Journal of The Electrochemical Society, Journal Year: 2023, Volume and Issue: 170(4), P. 047502 - 047502

Published: March 31, 2023

In the present study, a stable and more selective electrochemical sensor for catechol (CC) detection at magnetic molecularly imprinted polymer modified with green reduced graphene oxide glassy carbon electrode (MIP/rGO@Fe 3 O 4 /GCE). Two steps have been applied to achieve imprinting process: (1) adsorption of CC on surface polypyrrole (Ppyr) during polymerization pyrrole (2) extraction template from mass produced. Hence, paper doesn’t first use MIP technology identification but, it presents new process. The MIP/rGO@Fe3O4/GCE was characterized by voltammetry techniques exhibited wide linear range from1 50 μ M while limits were estimated be around 4.18 nM limit quantification in 12.69 CC. Furthermore, prepared MIP-based provided outstanding electroanalytical performances including high selectivity, stability, repeatability, reproducibility. For accurate estimation concentrations, an artificial neural network (ANN) developed based findings study. exhibits excellent stability very important selectivity sensitivity. analytical testing has analyzed water commercial milk samples adequate recoveries.

Language: Английский

Citations

31

Fiber‐Integrated Force Sensor using 3D Printed Spring‐Composed Fabry‐Perot Cavities with a High Precision Down to Tens of Piconewton DOI
Xinggang Shang, Ning Wang,

Simin Cao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 21, 2023

Abstract Developing microscale sensors capable of force measurements down to the scale piconewtons is fundamental importance for a wide range applications. To date, advanced instrumentations such as atomic microscopes and other specifically developed micro/nano‐electromechanical systems face challenges high cost, complex detection poor electromagnetic compatibility. Here, it presents unprecedented design 3D printing general fiber‐integrated using spring‐composed Fabry‐Perot cavities. It calibrates these devices employing varied‐diameter m‐scale silica particles standard weights. The sensitivity resolution reach values (0.436 ± 0.007) nmnN ‐1 (40.0 0.7) pN, respectively, which are best resolutions among all fiber‐based nanomechanical probes so far. also measured non‐linear airflow distributions produced from nozzle with an orifice 2 m, matches well full‐sized simulations. With further customization their geometries materials, anticipates easy‐to‐use probe can extend many applications air/fluidic turbulences sensing, micro‐manipulations, biological sensing.

Language: Английский

Citations

29

Nanotechnology-Enabled Biosensors: A Review of Fundamentals, Materials, Applications, Challenges, and Future Scope DOI
R. Abdel-Karim

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 759 - 777

Published: Jan. 17, 2024

When chemical, physical, or biological factors were being measured in the early years, large sensing types of equipment used. They also inaccurate and end user had to manually interpret even decode sensor output, addition limited stability. Nanoparticles, nanowires, carbon nanotubes (CNTs), nanorods, quantum dots (QDs) are some nanomaterials that frequently employed production nanobiosensors. The ability change color, great detection sensitivity, a huge surface area, high carrier capacity, stability, thermal electrical conductivity just few characteristics have. These systems can identify wide range clinically important molecules, including nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals, narcotic drugs, toxins, contaminants, whole cells variety media, from buffers more complex environments like urine, blood, sputum. most recent developments examined this research have enormous potential for using point-of-care diagnostics illness screening. current review focuses on principles nanotechnology-enabled biosensors their architectural design. classification nanobiosensors, various attributes, fabrication methods covered article. broadens people's perspectives materials used make uses biosensors.

Language: Английский

Citations

16