Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Jan. 28, 2025
Aim The study aimed to formulate solid lipid nanoparticles (SLNs) for the transdermal delivery of PPL improve skin retention and efficacy.
Language: Английский
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.
Language: Английский
Citations
4
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106328 - 106328
Published: Oct. 1, 2024
Language: Английский
Citations
4
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106598 - 106598
Published: Jan. 1, 2025
Language: Английский
Citations
0
Langmuir, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Designing efficient drug delivery systems for optimum therapeutic outcomes and minimum adverse effects remains a pivotal focus in pharmaceutical research. Understanding the nature of interactions between drugs carriers drug-release mechanism are key aspects development effective systems. This work presents detailed investigation into intricate niosomes Phenosafranin (PSF), subsequent release induced by variety cyclodextrins (CDs) employing multifaceted approach. Ensemble average spectroscopic single molecular level investigations based on fluorescence correlation spectroscopy (FCS), employed to explore binding PSF with niosome membrane. Subsequently, was studied disrupting structure using various CDs, their efficacy accessed through steady-state time-resolved photophysical responses. FCS experiments provided precise insights process at single-molecule variation translational diffusion characteristics drug. Additionally, isothermal titration calorimetric (ITC) further revealed thermodynamics governing CD-niosome host:guest varying potential different CDs which were validated electron microscopy confocal analyses. A broader analysis prepared nonionic surfactants highlighted influence cavitand size interaction constituents. comprehensive sheds light complex interplay these components interactions, providing applications.
Language: Английский
Citations
0
Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Jan. 28, 2025
Aim The study aimed to formulate solid lipid nanoparticles (SLNs) for the transdermal delivery of PPL improve skin retention and efficacy.
Language: Английский
Citations
0