Journal of Alzheimer s Disease,
Journal Year:
2023,
Volume and Issue:
93(3), P. 821 - 845
Published: April 28, 2023
Alzheimer’s
disease
(AD)
is
a
pathological
disorder
defined
by
the
symptoms
of
memory
loss
and
deterioration
cognitive
abilities
over
time.
Although
etiology
complex,
it
mainly
associated
with
accumulation
toxic
amyloid-β
peptide
(Aβ)
aggregates
tau
protein-induced
neurofibrillary
tangles
(NFTs).
Even
now,
creating
non-invasive,
sensitive,
specific,
cost-effective
diagnostic
methods
for
AD
remains
challenging.
Over
past
few
decades,
polymers,
nanomaterials
(e.g.,
nanodiamonds,
nanogold,
quantum
dots)
have
become
attractive
practical
tools
in
nanomedicine
diagnosis
treatment.
This
review
focuses
on
current
developments
sensing
such
as
enzyme-linked
immunosorbent
assay
(ELISA)
surface-enhanced
Raman
scattering
(SERS)
to
boost
sensitivity
detecting
related
biomarkers
AD.
In
addition,
optical
analysis
platforms
ELISA
SERS
found
increasing
popularity
among
researchers
due
their
excellent
specificity,
which
may
go
low
femtomolar
range.
While
offers
easy
technological
usage
high
throughput,
has
advantages
improved
mobility,
simple
electrical
equipment
integration,
lower
cost.
Both
portable
techniques
are
highly
superior
terms
sensitivity,
human
application,
practicality,
enabling
early
identification
biomarkers.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Aberrant
phase
separation-
and
stress
granule
(SG)-mediated
cytosolic
aggregation
of
TDP-43
in
motor
neurons
is
the
hallmark
amyotrophic
lateral
sclerosis
(ALS).
In
this
study,
we
found
that
graphene
quantum
dots
(GQDs)
potentially
modulate
during
SG
dynamics
separation.
The
intrinsically
disordered
region
C-terminus
exhibited
amyloid
fibril
formation;
however,
GQDs
inhibited
formation
fibrils
through
direct
intermolecular
interactions
with
TDP-43.
These
effects
were
accompanied
by
attenuation
ALS
phenotype
animal
models.
Additionally,
delayed
onset
survival
transgenic
mouse
models
enhancing
neuron
survival,
reducing
glial
activation,
neurons.
research,
demonstrated
efficacy
on
SG-mediated
binding
property
clinical
feasibility
using
several
other
types
caused
FUS
C9orf72.
Therefore,
could
offer
a
new
therapeutic
approach
for
proteinopathy-associated
ALS.
Inorganics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 92 - 92
Published: March 19, 2025
Utilizing
all-atom
molecular
dynamics
simulations,
in
the
current
study,
we
examine
how
three
different
graphene-based
nanosheets
(pristine
graphene,
graphene
oxide
and
edge-functionalized
graphene)
impact
self-assembly
mechanism
of
diphenylalanine
dipeptides
aqueous
solutions.
By
comparing
conformational
properties
presence
each
nanosheet,
elucidate
effects
existence
functional
groups,
their
type,
position
on
formed
nanostructures.
We
quantify
interaction
energy
between
nanosheets,
analyzing
various
energetic
components,
to
gain
insights
into
driving
forces
for
assembly
procedure
nanocomposite
systems.
Dipeptides
readily
coat
due
high
surface
affinity.
Subsequent
is
determined
by
nanofiller
type:
systems
with
edge
functionalized
there
an
increase
interfacial
layer
thickness,
while
system
pristine
a
structure
extended
top
coating
formed.
Additionally,
monitor
facilitate
dispersion
solution.
The
findings
this
work
enhance
our
understanding
interplay
paving
way
rational
design
novel
materials
tailored
specific
applications.
Small,
Journal Year:
2023,
Volume and Issue:
19(52)
Published: Aug. 30, 2023
Despite
being
one
of
the
most
promising
materials
in
anode
materials,
molybdenum
sulfide
(MoS2
)
encounters
certain
obstacles,
such
as
inadequate
cycle
stability,
low
conductivity,
and
unsatisfactory
charge-discharge
(CD)
rate
performance.
In
this
study,
a
novel
approach
is
employed
to
address
drawbacks
MoS2
.
Carbon
polymer
dots
(CPDs)
are
incorporated
prepare
three-dimensional
(3D)
nanoflower-like
spheres
@CPDs
through
self-assembly
2D
nanosheets,
followed
by
annealing
at
700
°C.
The
CPDs
play
main
role
creation
also
mitigate
nanosheet
limitations.
minimize
volume
changes
during
cycling
improve
performance,
leading
exceptional
performance
stability
both
Lithium-ion
Sodium-ion
batteries
(LIBs
SIBs).
optimized
@CPDs-2
electrode
achieves
superb
capacity
583.4
mA
h
g-1
high
current
density
(5
A
after
1000
cycles
LIBs,
remaining
302.8
500
5
SIBs.
Additionally,
full
cell
LIBs/SIBs
exhibits
good
demonstrating
its
potential
for
practical
application
fast-charging
high-energy
storage.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 14044 - 14044
Published: Sept. 13, 2023
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
that
affects
most
people
worldwide.
AD
complex
central
nervous
system
disorder.
Several
drugs
have
been
designed
to
cure
AD,
but
with
low
success
rates.
Because
the
blood–brain
and
blood–cerebrospinal
fluid
barriers
are
two
protect
system,
their
presence
has
severely
restricted
efficacy
of
many
treatments
studied
for
diagnosis
and/or
therapy.
The
use
nanoparticles
treatment
focus
an
established
rapidly
developing
field
nanomedicine.
Recent
developments
in
nanomedicine
made
it
possible
effectively
transport
brain.
However,
numerous
obstacles
remain
successful
nanomedicines
clinical
settings
treatment.
Furthermore,
given
rapid
advancement
therapeutics,
better
outcomes
patients
can
be
anticipated.
This
article
provides
overview
recent
using
different
types
management
AD.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(29)
Published: May 22, 2024
Alzheimer's
disease
(AD)
is
the
most
burdensome
aging-associated
neurodegenerative
disorder,
and
its
treatment
encounters
numerous
failures
during
drug
development.
Although
there
are
newly
approved
in-market
β-amyloid
targeting
antibody
solutions,
pathological
heterogeneity
among
patient
populations
still
challenges
outcome.
Emerging
advances
in
gene
therapies
offer
opportunities
for
more
precise
personalized
medicine;
while,
major
obstacles
including
populations,
puzzled
mechanism
druggable
target
development,
precision
delivery
of
functional
therapeutic
elements
across
blood-brain
barrier
remain
limit
use
therapy
central
neuronal
diseases.
Aiming
"precision
delivery"
challenges,
nanomedicine
provides
versatile
platforms
that
may
overcome
targeted
AD
therapy.
In
this
perspective,
to
picture
a
toolbox
strategy
recent
from
benchtop
clinics
highlighted,
possibly
available
targets,
tools,
outlined,
their
as
well
rational
design
addressed,
perspectives
promising
research
field
discussed.
ACS Chemical Neuroscience,
Journal Year:
2024,
Volume and Issue:
15(14), P. 2545 - 2564
Published: July 9, 2024
Alzheimer's
disease
(AD)
is
a
progressive
multifaceted
neurodegenerative
and
remains
formidable
global
health
challenge.
The
current
medication
for
AD
gives
symptomatic
relief
and,
thus,
urges
us
to
look
alternative
disease-modifying
therapies
based
on
multitarget
directed
approach.
Looking
at
the
remarkable
progress
made
in
peptide
drug
development
last
decade
benefits
associated
with
peptides,
they
offer
valuable
chemotypes
[multitarget
ligands
(MTDLs)]
as
therapeutics.
This
review
recapitulates
developments
harnessing
peptides
MTDLs
combating
by
targeting
multiple
key
pathways
involved
disease's
progression.
hold
immense
potential
represent
convincing
avenue
pursuit
of
novel
While
hurdles
remain,
ongoing
research
offers
hope
that
may
eventually
provide
approach
combat
AD.
