Synthesis,
Journal Year:
2024,
Volume and Issue:
56(24), P. 3870 - 3878
Published: Oct. 7, 2024
Abstract
The
development
of
new
catalytic
systems
that
enable
regio-
and
chemoselective
construction
diversely
functionalized
oxazocines
is
an
important
topic
in
organic
synthesis
pharmacochemistry.
Herein,
a
novel
Pd/Mengphos
complex
was
designed
applied
palladium-catalyzed
high-order
[4+4]
cycloaddition
2-substituted
allylic
carbonates
to
α,β-unsaturated
imines,
allowing
facile
access
versatile
good
yields
with
excellent
b/l
Z/E
selectivities
(up
92%
yield
complete
selectivities).
reaction
exhibited
broad
substrate
scope,
mild
conditions,
functional
group
compatibility.
In
addition,
asymmetric
version
has
also
been
tested,
affording
the
desired
moderate
enantioselectivity.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 17, 2024
Abstract
Oxazocines
are
key
structural
intermediates
in
the
synthesis
of
natural
products
and
pharmaceutical
molecules.
However,
oxazocines
especially
a
highly
enantioselective
manner,
is
long‐standing
formidable
challenge
due
to
unfavorable
energetics
involved
cyclization.
Herein,
series
new
PNP‐Ligand
P
‐chiral
stereocenter
first
designed
synthesized,
called
MQ‐Phos
,
successfully
applied
it
Pd‐catalyzed
higher‐order
formal
[4+4]‐cycloaddition
α
β
‐unsaturated
imines
with
2‐(hydroxymethyl)‐1‐arylallyl
carbonates.
The
reaction
features
mild
conditions,
excellent
regio‐
enantiocontrol
broad
substrate
scope
(54
examples).
Various
medium‐sized
rings
can
be
afforded
moderate
yields
(up
92%)
enantioselectivity
99%
ee).
newly
developed
critical
for
ring
catalytic
reactivity
enantioselectivity.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(34), P. 4537 - 4540
Published: Jan. 1, 2024
A
novel
method
was
devised
for
regioselective
ring
expansion
of
spirocyclopropanes
to
spirocyclobutanes
with
stabilized
sulfonium
ylides,
affording
1,2-
trans
-disubstituted
6,8-dioxaspiro[3.5]nonane-5,9-diones
without
the
formation
any
isomers.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(8), P. 6050 - 6067
Published: Jan. 1, 2025
Several
fused/binary
pyrazole
quinolinone
hybrids
are
synthesized
via
tandem
reactions
and
their
insecticidal
efficacy
against
S.
littoralis
A.
gossypii
evaluated.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(70)
Published: Sept. 23, 2023
Abstract
Silaspiranes
bearing
a
spiro‐silicon
center
are
promising
ring
frameworks
for
the
synthesis
of
novel
spirocyclic
molecules
possessing
unique
properties.
Development
efficient
methods
towards
these
structures
has
therefore
attracted
considerable
attentions
synthetic
chemists.
This
minireview
highlights
representative
advances
in
field,
and
is
categorized
into
four
parts
according
to
formation
strategies:
cyclization,
annulation,
expansion
cycloaddition.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(29), P. 3958 - 3961
Published: Jan. 1, 2024
A
controllable
spirocyclization
of
unsaturated
barbiturates
with
enamines
to
selectively
synthesize
spirobarbiturates
has
been
developed
under
ball-milling
conditions.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(11), P. 2596 - 2601
Published: April 9, 2024
Abstract
Under
the
catalysis
of
Rh
2
(OAc)
4
(10
mol%)
and
(±)‐Me‐Pybox
(20
in
1,2‐DCE
at
80
°C,
homocoupling/[4+1]
cycloaddition
cascade
diazobarbiturates
with
diazopyrazolones
proceeded
readily
provided
spirobarbiturates
32–88%
chemical
yields.
The
structure
obtained
was
identified
by
X‐ray
diffraction
analysis.
