Design, Synthesis and Evaluation of Photophysical and Biological Properties of Tetrafluoroacridine DOI
Naveen Kumar, Dibya Yadav, Omkar Indari

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(36)

Published: Sept. 19, 2024

Abstract 1,4,5,8‐Tetrafluoroacridine was successfully synthesized from 1,4,5,8‐tetrafluoroacridone through transfer hydrogenation using an in‐house ruthenium pincer catalyst followed by in situ dehydration. The synthetic protocol involves the copper‐catalyzed coupling of 2‐amino‐3,6‐difluorobenzoic acid 1 and 1,4‐difluoro‐2‐iodobenzene 2 to obtain 3 cyclization polyphosphoric get 4 . Common strategies for converting 1,4,5,8‐tetrafluoroacridine 5 were unsuccessful approach proved be most fruitful. 1,4,5,8‐Tetrafluoroacridone can N‐methylated give 9 investigation into photophysical properties , revealed that average photoluminescence (PL) lifetime acridine derivatives longer aqueous medium than ethanol methanol, indicating influence solvent environment on excited‐state dynamics. To assess their potential therapeutic applications, cytotoxic activity these compounds evaluated against AGS IMR‐32 cells, compound showed significant activity. addition methyl group acridone found helpful enhancing solubility biological

Language: Английский

Electrochemical synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzamides with ethylene glycol as the methylene source DOI
Yue Zhang, Mingzhu Liu, Kun Zhao

et al.

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 557, P. 113880 - 113880

Published: Feb. 28, 2024

Language: Английский

Citations

2
Thermo-promoted annulation of arylboronic acids with anthranils under catalyst-free conditions: Access to acridines DOI Creative Commons
Jing Jiang, Peng Xie,

Yue Gao

et al.

Journal of Chemical Research, Journal Year: 2024, Volume and Issue: 48(1)

Published: Jan. 1, 2024

Acridine derivatives have exhibited great application prospects in organic photovoltaic devices. An efficient and atomically economical synthetic method was developed for the production of acridines from anthranils using arylboronic acids. This protocol features no catalysts, good functional group tolerance, operational simplicity. catalyst-free process afforded various moderate to yields, providing an platform investigation untapped reactions at high temperatures.

Language: Английский

Citations

0
Recent Advances in the Synthesis and Optical Applications of Acridine-based Hybrid Fluorescent Dyes DOI
Mehdi Pordel,

Hanieh Gheibi,

A. Sharif

et al.

Journal of Fluorescence, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

Citations

0
Design, Synthesis and Evaluation of Photophysical and Biological Properties of Tetrafluoroacridine DOI
Naveen Kumar, Dibya Yadav, Omkar Indari

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(36)

Published: Sept. 19, 2024

Abstract 1,4,5,8‐Tetrafluoroacridine was successfully synthesized from 1,4,5,8‐tetrafluoroacridone through transfer hydrogenation using an in‐house ruthenium pincer catalyst followed by in situ dehydration. The synthetic protocol involves the copper‐catalyzed coupling of 2‐amino‐3,6‐difluorobenzoic acid 1 and 1,4‐difluoro‐2‐iodobenzene 2 to obtain 3 cyclization polyphosphoric get 4 . Common strategies for converting 1,4,5,8‐tetrafluoroacridine 5 were unsuccessful approach proved be most fruitful. 1,4,5,8‐Tetrafluoroacridone can N‐methylated give 9 investigation into photophysical properties , revealed that average photoluminescence (PL) lifetime acridine derivatives longer aqueous medium than ethanol methanol, indicating influence solvent environment on excited‐state dynamics. To assess their potential therapeutic applications, cytotoxic activity these compounds evaluated against AGS IMR‐32 cells, compound showed significant activity. addition methyl group acridone found helpful enhancing solubility biological

Language: Английский

Citations

0