Biomaterials-based phototherapy for bacterial infections

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Bacterial infections and antibiotic resistance are global health problems, current treatments for bacterial still rely on the use of antibiotics. Phototherapy based a photosensitizer has high efficiency, broad spectrum, strong selectivity, does not easily induce drug resistance, is expected to become an effective strategy treatment infections, particularly drug-resistant infections. This article reviews antimicrobial strategies phototherapy photosensitizers, including photodynamic therapy (PDT), photothermal (PTT), their combination. These methods have significant application potential in combating multi-drug-resistant biofilm providing alternative traditional antibiotics chemical antibacterial agents.

Language: Английский

---

Comparing PVP and Polymeric Micellar Formulations of a PEGylated Photosensitizing Phthalocyanine by NMR and Optical Techniques

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(8), P. 4165 - 4183

Published: July 26, 2023

Phthalocyanines are ideal candidates as photosensitizers for photodynamic therapy (PDT) of cancer due to their favorable chemical and photophysical properties. However, tendency form aggregates in water reduces PDT efficacy poses challenges obtaining efficient forms phthalocyanines therapeutic applications. In the current work, polyvinylpyrrolidone (PVP) micellar formulations were compared encapsulating monomerizing a water-soluble zinc phthalocyanine bearing four non-peripheral triethylene glycol chains (Pc1). 1H NMR spectroscopy combined with UV–vis absorption fluorescence revealed that Pc1 exists mixture regioisomers monomeric dimethyl sulfoxide but dimers an aqueous buffer. PVP, polyethylene castor oil (Kolliphor RH40), three different triblock copolymers varying proportions polypropylene units (termed P188, P84, F127) tested carriers Pc1. shift analysis, diffusion-ordered spectroscopy, 2D nuclear Overhauser enhancement was applied monitor encapsulation localization at polymer interface. Kolliphor RH40 F127 micelles exhibited highest affinity core resulted intense emission well singlet oxygen formation along PVP. Among copolymers, efficiency binding dimer dissolution decreased order > P84 P188. PVP strong binder molecules rather surface-attached exist monomer mixtures. The results demonstrate optical offer powerful tools assess parameters like drug binding, sites, dynamic properties play key roles achieving high host–guest compatibility. With corresponding adjustments, polymeric can simple easily accessible delivery systems optimizing phthalocyanines' photosensitizers.

Language: Английский

---

Zinc Phthalocyanine Core‐First Star Polymers Through Nitroxide Mediated Polymerization and Nitroxide Exchange Reaction

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract Nitroxide‐mediated polymerization (NMP) and nitroxide exchange reaction (NER) are very efficient methodologies that require only suitable alkoxyamine derivatives create different polymeric architectures in a controlled manner. Herein, the synthesis of star polymers containing TEMPO‐substituted symmetric zinc phthalocyanine (ZnPc) is presented via NMP NER. Moreover, linear polymer formation conducted single arm on asymmetric ZnPc to elucidate properties polymers. All characterized by FT‐IR, UV–vis, fluorescence, GPC, NMR, EPR techniques. The results show proposed reactions capable forming star‐shaped increasing number (from four arms) variable dispersity values ( Đ ) (1.2–3) due lengths, especially NMP. However, this difficulty has been overcome NER, have successfully synthesized with relatively low molecular weight (30 K > 10 K) (1.2–1.9). clearly indicate while styrene 4‐vinyl benzyl chloride monomers introduced structure equally, can be manner, their quarternized potential effective as photoactive agents photodynamic therapy.

Language: Английский

---

Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties

Materials, Journal Year: 2023, Volume and Issue: 16(22), P. 7060 - 7060

Published: Nov. 7, 2023

In the present work, cholesterol (Chol)-substituted zinc phthalocyanine (Chol-ZnPc) and its composite with graphene oxide (GO) were prepared for photodynamic therapy (PDT) applications. Briefly, Chol-substituted phthalonitrile (Chol-phthalonitrile) was synthesized first through substitution of Chol to group over oxygen bridge. Then, Chol-ZnPc by a tetramerization reaction Chol-phthalonitrile ZnCl2 in basic medium. Following this, GO introduced Chol-ZnPc, successful preparation samples verified FT-IR, UV-Vis, 1H-NMR, MALDI-TOF MS, SEM, elemental analysis. Regarding PDT properties, we report that exhibited singlet quantum yield (Φ∆) 0.54, which is slightly lower than unsubstituted ZnPc. Upon introduction GO, GO/Chol-ZnPc higher Φ∆, about 0.78, Moreover, this enhancement realized simultaneous improvement fluorescence (ΦF) 0.36. addition, DPPH results suggest low antioxidant activity despite presence GO. Overall, might provide combined benefits PDT, particularly terms image guidance generation.

Language: Английский

---