Biomaterials-based phototherapy for bacterial infections
Guangzhi Wu,
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Zhuo Xu,
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Yue Yu
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et al.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 4, 2024
Bacterial
infections
and
antibiotic
resistance
are
global
health
problems,
current
treatments
for
bacterial
still
rely
on
the
use
of
antibiotics.
Phototherapy
based
a
photosensitizer
has
high
efficiency,
broad
spectrum,
strong
selectivity,
does
not
easily
induce
drug
resistance,
is
expected
to
become
an
effective
strategy
treatment
infections,
particularly
drug-resistant
infections.
This
article
reviews
antimicrobial
strategies
phototherapy
photosensitizers,
including
photodynamic
therapy
(PDT),
photothermal
(PTT),
their
combination.
These
methods
have
significant
application
potential
in
combating
multi-drug-resistant
biofilm
providing
alternative
traditional
antibiotics
chemical
antibacterial
agents.
Language: Английский
Comparing PVP and Polymeric Micellar Formulations of a PEGylated Photosensitizing Phthalocyanine by NMR and Optical Techniques
Lea P. Gergely,
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Çiğdem Yüceel,
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Ümit İşçi
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et al.
Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(8), P. 4165 - 4183
Published: July 26, 2023
Phthalocyanines
are
ideal
candidates
as
photosensitizers
for
photodynamic
therapy
(PDT)
of
cancer
due
to
their
favorable
chemical
and
photophysical
properties.
However,
tendency
form
aggregates
in
water
reduces
PDT
efficacy
poses
challenges
obtaining
efficient
forms
phthalocyanines
therapeutic
applications.
In
the
current
work,
polyvinylpyrrolidone
(PVP)
micellar
formulations
were
compared
encapsulating
monomerizing
a
water-soluble
zinc
phthalocyanine
bearing
four
non-peripheral
triethylene
glycol
chains
(Pc1).
1H
NMR
spectroscopy
combined
with
UV–vis
absorption
fluorescence
revealed
that
Pc1
exists
mixture
regioisomers
monomeric
dimethyl
sulfoxide
but
dimers
an
aqueous
buffer.
PVP,
polyethylene
castor
oil
(Kolliphor
RH40),
three
different
triblock
copolymers
varying
proportions
polypropylene
units
(termed
P188,
P84,
F127)
tested
carriers
Pc1.
shift
analysis,
diffusion-ordered
spectroscopy,
2D
nuclear
Overhauser
enhancement
was
applied
monitor
encapsulation
localization
at
polymer
interface.
Kolliphor
RH40
F127
micelles
exhibited
highest
affinity
core
resulted
intense
emission
well
singlet
oxygen
formation
along
PVP.
Among
copolymers,
efficiency
binding
dimer
dissolution
decreased
order
>
P84
P188.
PVP
strong
binder
molecules
rather
surface-attached
exist
monomer
mixtures.
The
results
demonstrate
optical
offer
powerful
tools
assess
parameters
like
drug
binding,
sites,
dynamic
properties
play
key
roles
achieving
high
host–guest
compatibility.
With
corresponding
adjustments,
polymeric
can
simple
easily
accessible
delivery
systems
optimizing
phthalocyanines'
photosensitizers.
Language: Английский
Zinc Phthalocyanine Core‐First Star Polymers Through Nitroxide Mediated Polymerization and Nitroxide Exchange Reaction
Erem Ahmetali,
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Azra Kocaarslan,
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Stefan Bräse
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et al.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 28, 2024
Abstract
Nitroxide‐mediated
polymerization
(NMP)
and
nitroxide
exchange
reaction
(NER)
are
very
efficient
methodologies
that
require
only
suitable
alkoxyamine
derivatives
create
different
polymeric
architectures
in
a
controlled
manner.
Herein,
the
synthesis
of
star
polymers
containing
TEMPO‐substituted
symmetric
zinc
phthalocyanine
(ZnPc)
is
presented
via
NMP
NER.
Moreover,
linear
polymer
formation
conducted
single
arm
on
asymmetric
ZnPc
to
elucidate
properties
polymers.
All
characterized
by
FT‐IR,
UV–vis,
fluorescence,
GPC,
NMR,
EPR
techniques.
The
results
show
proposed
reactions
capable
forming
star‐shaped
increasing
number
(from
four
arms)
variable
dispersity
values
(
Đ
)
(1.2–3)
due
lengths,
especially
NMP.
However,
this
difficulty
has
been
overcome
NER,
have
successfully
synthesized
with
relatively
low
molecular
weight
(30
K
>
10
K)
(1.2–1.9).
clearly
indicate
while
styrene
4‐vinyl
benzyl
chloride
monomers
introduced
structure
equally,
can
be
manner,
their
quarternized
potential
effective
as
photoactive
agents
photodynamic
therapy.
Language: Английский
Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties
Materials,
Journal Year:
2023,
Volume and Issue:
16(22), P. 7060 - 7060
Published: Nov. 7, 2023
In
the
present
work,
cholesterol
(Chol)-substituted
zinc
phthalocyanine
(Chol-ZnPc)
and
its
composite
with
graphene
oxide
(GO)
were
prepared
for
photodynamic
therapy
(PDT)
applications.
Briefly,
Chol-substituted
phthalonitrile
(Chol-phthalonitrile)
was
synthesized
first
through
substitution
of
Chol
to
group
over
oxygen
bridge.
Then,
Chol-ZnPc
by
a
tetramerization
reaction
Chol-phthalonitrile
ZnCl2
in
basic
medium.
Following
this,
GO
introduced
Chol-ZnPc,
successful
preparation
samples
verified
FT-IR,
UV-Vis,
1H-NMR,
MALDI-TOF
MS,
SEM,
elemental
analysis.
Regarding
PDT
properties,
we
report
that
exhibited
singlet
quantum
yield
(Φ∆)
0.54,
which
is
slightly
lower
than
unsubstituted
ZnPc.
Upon
introduction
GO,
GO/Chol-ZnPc
higher
Φ∆,
about
0.78,
Moreover,
this
enhancement
realized
simultaneous
improvement
fluorescence
(ΦF)
0.36.
addition,
DPPH
results
suggest
low
antioxidant
activity
despite
presence
GO.
Overall,
might
provide
combined
benefits
PDT,
particularly
terms
image
guidance
generation.
Language: Английский