Piezoelectric Polarization Enhanced Photogenerated Carrier Separation of Bi2S3–BaTiO3 Nanostructure-Based Photoelectric Poly-L-lactic Acid Scaffold for Stimulating Cell Growth DOI
Cijun Shuai, Xiuwen Gao, Yifeng Wang

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(23), P. 21934 - 21944

Published: Nov. 27, 2023

Bismuth sulfide (Bi2S3) could respond to near-infrared light generate photocurrent, demonstrating tremendous potential in constructing self-powered electrical stimulation accelerate bone regeneration. Nevertheless, the facile recombination of electron–hole pairs undermined its photoelectric performance. Herein, a sea-buckthorn-like nanostructured Bi2S3–BaTiO3 was synthesized by loading BaTiO3 nanoparticles onto Bi2S3 nanorods through self-assembly method and then integrated into poly-L-lactic acid (PLLA) powders fabricate PLLA/Bi2S3–BaTiO3 scaffolds. Piezoelectric would deform under stress produce instantaneous polarization, which triggered positive negative charges presented on relative surfaces BaTiO3. Thus, photogenerated electrons holes be, respectively, transferred charged BaTiO3, thereby achieving separation. Results revealed that ultrasonic irradiation, photoluminescence peak intensity significantly reduced compared with Bi2S3, confirming improved pair Accordingly, photocurrent increased approximately 1.4 times comparison Bi2S3. The enhanced effectively promoted cell proliferation differentiation upregulating alkaline phosphatase expression, enhancing calcium nodule deposition, promoting cellular Ca2+ influx. Consequently, this work provided perspective for establishing stimulated scaffold repair.

Language: Английский

Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity DOI
Cijun Shuai,

Xiaoxin Shi,

Kai Wang

et al.

Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(2), P. 105 - 120

Published: Feb. 27, 2024

Language: Английский

Citations

45
Heterogeneous grain structure in biodegradable Zn prepared via mechanical alloying and laser powder bed fusion for strength-plasticity synergy DOI Creative Commons
Cijun Shuai, Yang Zhao, Youwen Deng

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 21, 2024

This study presented a unique process of mechanical alloying (MA) and laser powder bed fusion (LPBF) to prepare heterogeneous grain structure (HGS) Zn with strength-plasticity synergy. The results showed that the MA-treatment significantly refined sizes nano-scale contributed formation HGS powders. Moreover, ultra-fast heating cooling LPBF inhibited growth resulted in specific core/shell HGS, wherein cores (micron-grains) were surrounded by interconnected shells (nano-grains). Notably, prepared demonstrated synergistically improved compressive yield strength (2.1 times) plasticity (58%) compared homogeneous coarse-grained counterparts. impressive synergy was primarily attributed high back stress dislocation pile-ups generated deformation incompatibility between nano-grained micron-grained cores. These findings open up new fields for MA preparation metals their applications solving tradeoff.

Language: Английский

Citations

38
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

24
Construction of antibacterial bone implants and their application in bone regeneration DOI
Pei Feng,

Ruizhong He,

Yulong Gu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(3), P. 590 - 625

Published: Nov. 10, 2023

In order to address the issue of bacterial infection during transplantation bone implants, four types implants with long-term antimicrobial functionality have been constructed.

Language: Английский

Citations

42
Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds DOI
Fangwei Qi, Huixing Li, Xiuwen Gao

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(2), P. 495 - 506

Published: Dec. 4, 2023

Although barium titanate (BaTiO

Language: Английский

Citations

38
Recent advances using MXenes in biomedical applications DOI
I‐Chi Lee, Yi‐Chen Ethan Li, James L. Thomas

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(4), P. 876 - 902

Published: Dec. 1, 2023

The structure of this review includes applications MXenes in drug delivery, tissue engineering, antimicrobial, and biosensors.

Language: Английский

Citations

34
Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration DOI Creative Commons
Zhixin Li,

Yinjin Shao,

Youwen Yang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 9, 2024

Extensive research on zeolitic imidazolate framework (ZIF-8) and its derivatives has highlighted their unique properties in nanomedicine. ZIF-8 exhibits advantages such as pH-responsive dissolution, easy surface functionalization, efficient drug loading, making it an ideal nanosystem for intelligent delivery phototherapy. These characteristics have sparked significant interest potential applications tissue regeneration, particularly bone, skin, nerve regeneration. This review provides a comprehensive assessment of ZIF-8’s feasibility engineering, encompassing material synthesis, performance testing, the development multifunctional nanosystems. Furthermore, latest advancements field, well limitations future prospects, are discussed. Overall, this emphasizes developments engineering highlights nanoplatforms effective complex repair.

Language: Английский

Citations

10
Engineered MXene Biomaterials for Regenerative Medicine DOI

Shengmin Zhang,

Liang Wang, Zhichao Feng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

Citations

1
Co-continuous structure enhanced magnetic responsive shape memory PLLA/TPU blend fabricated by 4D printing DOI Creative Commons
Pei Feng, Rongyang Zhao, Feng Yang

et al.

Virtual and Physical Prototyping, Journal Year: 2023, Volume and Issue: 19(1)

Published: Dec. 28, 2023

Combining poly (L-lactic acid) (PLLA) with thermoplastic polyurethane elastomer (TPU) can integrate the advantages of excellent biocompatibility and intrinsic shape memory ability PLLA high elasticity properties TPU in application minimally invasive surgery for bone tissue engineering. However, easily forms a sea-island-like structure matrix, decreasing properties. In this study, co-continuous phase matrix was constructed by adding Fe3O4 nanoparticles due to changed interfacial tension flow behavior TPU, which endowed TPU/PLLA/Fe3O4 blend fabricated via selective laser sintering (SLS) As result, morphology from complete increasing content (0 10wt%), recovery ratios 50 °C water increased 66.67 95.92%. The introduction magnetic responsive alternating field because could heat it generating relative friction particle collisions. Besides, tensile modulus hardness specimen 10wt% increased. addition, demonstrated promoting cell adhesion, spreading, proliferation.

Language: Английский

Citations

18
MXene-Reinforced Composite Cryogel Scaffold for Neural Tissue Repair DOI Creative Commons
Mohamed Zoughaib,

Svetlana Avdokushina,

Irina N. Savina

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 479 - 479

Published: Jan. 22, 2025

The development of effective materials for neural tissue repair remains a major challenge in regenerative medicine. In this study, we present novel MXene-reinforced composite cryogel scaffold designed regeneration. MXenes, class two-dimensional with high conductivity and biocompatibility, were integrated into polyvinyl alcohol (PVA) matrix via cryopolymerization to form macroporous, mechanically stable scaffold. morphology, mechanical properties, swelling behavior the different MXene contents have been assessed. effects on viability/proliferation differentiation cells (PC-12) cultured elucidated. MXene/PVA demonstrated excellent cell-supporting potential, not only showing no toxicity but also promoting proliferation PC-12. Additionally, induced neuritogenesis-like process as evidenced by morphological changes enhanced expression marker β-III-tubulin. neuroprotective properties component revealed alleviation oxidative stress reduction intracellular ROS levels. These findings highlight potential MXene-embedded PVA promising material that can be further used conjunction electrostimulation therapy advancing strategies engineering.

Language: Английский

Citations

0