Catalysts,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1163 - 1163
Published: Oct. 2, 2022
N-heterocycles
are
ubiquitous
in
natural
products,
pharmaceuticals,
organic
materials,
and
numerous
functional
molecules.
Among
the
current
synthetic
approaches,
transition
metal-catalyzed
C–H
functionalization
has
gained
considerable
attention
recent
years
due
to
its
advantages
of
simplicity,
high
atomic
economy,
ready
availability
starting
materials.
In
field
N-heterocycle
synthesis
via
functionalization,
nickel
been
recognized
as
one
most
important
catalysts.
this
review,
we
will
introduce
nickel-catalyzed
intramolecular
intermolecular
pathways
for
from
2008
2021.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(2), P. 597 - 630
Published: Nov. 23, 2023
This
review
highlights
the
recent
progress
in
electrochemical
difunctionalization
of
alkenes
and
alkynes
involving
C–S/Se
bond
formation
to
access
organochalcogen
frameworks.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(40), P. 7288 - 7293
Published: Oct. 4, 2022
A
ruthenium-catalyzed
peri-selective
C-H
activation
and
annulation
of
1-naphthols
with
CF3-substituted
imidoyl
sulfoxonium
ylides
that
uses
hydroxyl
as
a
weakly
coordinating
directing
group
is
disclosed.
The
strategy
provides
facile
practical
route
to
diverse
trifluoromethyl-containing
2,3-dihydrobenzo[de]chromen-2-amines
high
efficiency.
Notable
advantages
this
protocol
include
readily
available
materials,
excellent
regioselectivity,
good
functional
compatibility,
scalability.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(32), P. 6293 - 6313
Published: Jan. 1, 2022
As
one
of
the
most
important
structural
units
in
pharmaceuticals
and
medicinal
chemistry,
quinazolinone
its
derivatives
exhibit
a
wide
range
biological
pharmacological
activities,
including
anti-inflammatory,
antitubercular,
antiviral,
anticancer
etc.
In
particular,
2,3-fused
quinazolinones
have
attracted
much
attention
because
rings
fused
to
2,3-positions
improve
their
rigidity
planarity.
Their
synthetic
strategies
made
great
advances
recent
years.
Therefore,
this
review
focuses
on
novel
for
synthesis
from
2017
2022,
such
as
difunctionalization
alkenes,
ring-opening
easily
available
small
rings,
dehydrogenative
cross-coupling
reactions,
transition-metal
catalyzed
cyclizations,
cycloadditions,
other
cascade
reactions.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(23), P. 14754 - 14772
Published: Nov. 18, 2022
Carboamination
of
readily
available
feedstock-like
alkenes,
alkynes,
and
allenes
has
proven
to
be
an
efficient
powerful
tool
for
the
synthesis
diverse
valuable
amine
derivatives
relevance
medicinal
chemistry,
biochemistry,
material
science.
Among
these
developed
carboamination
methodologies,
direct
use
C–H
activation
strategy
leverage
process
is
particularly
attractive
due
ubiquity
such
bonds
in
organic
molecules.
In
this
review,
we
provide
overview
development
intermolecular
across
C–C
π-bonds
initiated
by
a
redox-neutral
nonannulative
manner,
with
emphasis
on
synthetic
mechanistic
aspects.
principle,
review
summarized
reactions
key
feature
involving
initial
metalation
followed
migratory
insertion
into
terminated
electrophilic
amination
quenching,
thus,
it
ordered
sources
C-
N-based
functionalities
further
divided
π-compounds.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
A
cascade
reaction
of
Pd(II)/dppben-catalyzed
[3
+
2]
cycloaddition
N-aryl
nitrones
with
allenoates
and
sequential
reduction
has
been
developed
for
the
synthesis
functionalized
benzazepines
bearing
three
contiguous
carbon
stereocenters
in
moderate
to
good
yields
ranging
from
15
82%
high
diastereoselectivity.
The
obtained
could
be
converted
into
various
benzazepine
scaffolds,
an
estrone-derived
scaffold
was
prepared
over
four
steps
estrone.
More
importantly,
chiral
88%
ee
value
auxiliary.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
21(10), P. 2046 - 2058
Published: Nov. 18, 2022
This
review
describes
several
key
activation
methods
for
Langlois'
reagent
in
the
difunctionalization
of
alkenes
and
could
stimulate
interest
readers
promoting
wider
development
application
reagent.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(5), P. 1289 - 1295
Published: Jan. 1, 2023
We
developed
a
palladium-catalyzed
four-component
carbonylative
cyclization
of
alkenyl-tethered
aryl
iodides,
trifluoroacetimidoyl
chlorides
and
propargyl
amines
for
the
construction
carbonyl-bridged
bisheterocycles.
