Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(15), P. 3101 - 3104
Published: Jan. 1, 2023
Herein,
a
Cu(II)-catalyzed
facile
construction
of
synthetically
valuable
spiro
compounds
from
β-naphthols
in
air
is
reported,
which
N,N-dimethylaminoethanol
(DMEA)
serves
as
an
efficient
and
unique
C1
synthon.
This
transformation
proceeds
through
ortho-quinone
methide
(o-QM)
formation/Michael
addition/dearomatization
sequence,
affording
various
spiro(naphthalenenaphtho)furan-2-ones
moderate
to
excellent
yields.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(6), P. 3941 - 3953
Published: Feb. 29, 2024
An
efficient
synthetic
method
for
constructing
2,3-
and
2,4-disubstituted
pyrimidio[1,2-b]indazole
skeletons
through
I2-DMSO-mediated
substrate-controlled
regioselective
[4
+
2]
cyclization
is
reported.
The
reaction
conditions
are
mild,
its
operation
simple,
the
substrate
scope
wide.
More
than
60
derivatives
have
been
synthesized,
providing
a
new
methodology
related
molecules
potentially
enriching
bioactive-molecule
libraries.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(28), P. 5822 - 5826
Published: Jan. 1, 2024
One-step
construction
of
both
5-arylpyrazolo[1,5-
a
]pyrimidines
and
2-arylpyrimido[1,2-
b
]indazoles
using
inexpensive,
abundant
easy-to-handle
calcium
carbide
as
solid
alkyne
source
is
depicted.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(6), P. 1430 - 1435
Published: Jan. 23, 2024
Abstract
A
substrate‐induced
synthesis
of
coumarin‐fused
quinolinones
is
achieved
from
4‐(phenylamino)‐2
H
‐chromen‐2‐ones
using
N
‐alkyl
amines
as
the
solvent
and
a
carbon
source
under
air
conditions
without
any
catalysts
in
one
pot.
This
protocol
highlights
special
roles
which
were
not
only
used
reactants
but
also
an
internal
oxidant
selectively
activated
‐
α
‐C(
sp
3
)−H
bond.
reaction
features
catalyst‐free,
broad
substrate
scopes
(
27
examples
24
examples),
operationally
simple
for
one‐step
synthesis,
recovery
recycling
solvent.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
We
have
developed
a
novel
ultrasound
technique
that
generates
significant
amounts
of
CF3-substituted
benzo[4,5]
imidazo
[1,2-a]pyrimidine
analogues
from
easily
accessible
starting
materials
in
an
ecologically
friendly
and
efficient
approach.
This
method
is
notably
helpful
for
producing
physiologically
relevant
compounds
containing
the
imidazopyrimidine
unit,
which
serves
as
versatile
building
block
synthesis
N-fused
heterocycles
devoid
metals,
solvents,
additives,
catalysts.
Additionally,
utilizing
open-air
environment,
range
polyfluoro-ynones
were
successfully
reacted
with
2-aminobenzimidazole,
generating
diverse
array
polyfluoroimidazo[1,2-a]pyrimidine
derivatives.
Furthermore,
by
employing
integrated
flow
system
approach,
we
able
to
synthesize
polyfluoro-substituted
benzo[4,5]imidazo[1,2-a]pyrimidine
derivatives
alkynes
much
shorter
reaction
time.
Gram-scale
proved
this
method's
scalability
highlighted
its
potential
synthetic
industrial
applications.
The
straightforward
nature
process,
broad
compatibility
various
functional
groups,
substantial
sustainability
advantages
collectively
underscore
significance.
