Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 383 - 425
Published: Jan. 1, 2023
Language: Английский
Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(18), P. 2991 - 3019
Published: July 14, 2023
Abstract Propargylic alcohols are readily available bifunctional (alkyne and hydroxyl groups) synthons, which recognize as one of the attractive synthetic feedstock in organic transformations. Especially, recent years employment these valuable molecules has frequently been observed literature. Hence, present review highlights advancements application propargylic cyclization, substitution, addition reactions.
Language: Английский
Citations
16
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(6), P. 1811 - 1816
Published: Jan. 1, 2024
An efficient protocol to construct spiro[indole-3,4′-pyrazol]-5′-ones via ruthenium( ii )-catalyzed selective C–H bond activation/[4 + 1] spirocyclization starting from easily available N -aryl amidines and diazopyrazolones has been developed.
Language: Английский
Citations
4
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
The effective assembly of benzazepine skeletons in a sustainable and atom-economical fashion remains challenging goal modern organic synthesis. Presented herein is novel synthesis indazole fused 2-benzazepine derivatives based on formal [4 + 3] annulation 3-aryl-1H-indazoles with cyclopropenones. formation products proceeds through Ir(III)-catalyzed aryl C-H bond metalation cyclopropenone ring-opening leading to acylation, followed by an intramolecular N-nucleophilic conjugated addition. By using this method, number valuable were effectively generated. This protocol addresses the challenges constructing medium-sized rings cascade C-H/C-C activation C-C/C-N formation. Moreover, photophysical properties thus obtained also evaluated. It turned out that all compounds tested showed solvent polarity-dependent fluorescence features, which could be potentially applied for revealing polarity their immediate environments.
Language: Английский
Citations
0
Organic Letters, Journal Year: 2023, Volume and Issue: 25(16), P. 2923 - 2927
Published: April 17, 2023
An efficient approach for the synthesis of N-substituted indenoisoquinolinones via rhodium(III)-catalyzed C-H bond activation/subsequent [4 + 2] cyclization starting from easily available 2-phenyloxazolines and 2-diazo-1,3-indandiones has been developed. A series indeno[1,2-c]isoquinolinones were obtained in up to 93% yield through functionalization, followed by intramolecular annulation, elimination, ring-opening a "one pot manner" under mild reaction conditions. This protocol features excellent atom- step-economy provides novel strategy chance study their biological activities.
Language: Английский
Citations
7
Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(29), P. 5985 - 5989
Published: Jan. 1, 2023
A convenient method for the alkylation of 3-arylbenzo[d]isoxazoles with maleimides under redox-neutral conditions has been developed, giving a series substituted succinimides in up to 99% yield. This transformation is highly selective give succinimides, and Heck-type products are successfully avoided. protocol features 100% atom-economy broad substrate tolerance, provides novel strategy synthesis diverse an opportunity succinylation protein medication pharmacologists discover first-in-class drugs.
Language: Английский
Citations
6
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(8), P. 1840 - 1846
Published: Feb. 8, 2024
Abstract Herein, we report a chemo‐ and regioselective Rh‐catalyzed redox C7‐spiroannulation reaction of N ‐benzo[ d ]imidazole indolines with maleimides, resulting in series indoline fused azaspirocycles up to 92% yield. The synthetic utility is demonstrated by the synthesis highly functionalized nitrogen‐containing spiropolycyclic skeletons. annulation could also be performed maleic esters acrylates. products were purified simple filtration. Rh catalyst can recycled, at gram‐scale using 0.5 mol% catalyst, which makes this protocol potentially applicable industry. Moreover, efficient post‐modification pharmaceutical molecules demonstrates its practicability.
Language: Английский
Citations
2
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(8), P. 5589 - 5605
Published: April 5, 2024
Diversity-oriented synthesis strategy for the efficient assembly of indole-fused polycyclic scaffolds via rhodium-catalyzed NH-indole-directed C–H coupling with propargylic alcohol derivatives in a regioselective manner was developed. Five 2-phenyl-1H-indole-embedded core skeletons were synthesized. In particular, three different exo-olefin-containing polycycles realized, which may be manipulated further chemistry.
Language: Английский
Citations
1
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(24), P. 6915 - 6919
Published: Jan. 1, 2022
A novel rhodium-catalyzed formal [2 + 2 1] annulation of alkynes with arylboronic acids to produce 1,1-disubstituted 1( H )-indenes is developed.
Language: Английский
Citations
6
Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 13(1)
Published: Nov. 29, 2023
Abstract An efficient and regioselective synthesis of various functionalized isoquinoline N ‐oxides has been realized by Rh(III)‐catalyzed oxidative annulation aryl oximes with tertiary propargyl alcohols. The current protocol features readily available starting materials, mild reaction conditions, broad substrate scope wide functional group tolerance.
Language: Английский
Citations
3
Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 383 - 425
Published: Jan. 1, 2023
Language: Английский
Citations
1