Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations DOI
Yungui Peng, S. Ullah,

Zulfiqar Hussain

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Diazophosphonates function as indispensable synthetic intermediates within the domain of organic chemistry, serving precursors for a diverse range molecules, with potential applications bioactive compounds. α-Diazomethylphosphonates showcase expansive reactivity and elevated levels enantioselectivity in asymmetric transformations, especially conjunction suitable catalyst systems. This review compiles latest advancements diazophosphonate chemistry from 2016 to 2024, highlighting their transformative synthesis. Diazophosphonates, regarded revolutionary compounds, exhibit unique attributes carbene precursors, driving chemical reactions such [3+2] cycloaddition, [3+3] substitution reactions. Their adaptability functional group conversions underscores pivotal role various methodologies. The highlights growing interest among chemists, fostering novel strategies expanding application horizons. multifaceted utility diazophosphonates reagents, intermediates, catalysts significance modern pharmaceutical applications, prompting further exploration into this dynamic field. 1 Introduction 2 Cycloaddition Reactions 3 Asymmetric 4 5 Substitution 6 Carbene Precursors 7 Chemistry Fluorinated Compounds 8 Other 9 Future Directions 10 Conclusion

Language: Английский

Synthesis of functionalized sulfilimines via iron-catalyzed sulfur alkylation of sulfenamides with diazo compounds DOI

Xianda Wu,

Minghong Chen, Fu‐Sheng He

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(22), P. 9092 - 9096

Published: Jan. 1, 2023

An efficient iron-catalyzed sulfur alkylation of sulfenamides with diazo compounds for the synthesis functionalized sulfilimines is developed under air conditions.

Language: Английский

Citations

12
Application of BF3•OEt2 in Organic Synthesis as a Catalyst or Synthon DOI

Zu‐Jia Chen,

Shi‐Wei Yu,

Yongjun Zhou

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(9), P. 3107 - 3107

Published: Jan. 1, 2023

Language: Английский

Citations

4
Catalytic Asymmetric Formal C–C Bond Insertion Reaction of Aldehydes via 1,2-Acyl Shift: Construction of All-Carbon Quaternary Stereocenters with Three Carbonyl Groups DOI
Hyemin Jeong, Jin Won Lee, Dong Kyu Kim

et al.

ACS Catalysis, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 11, 2023

The formal C–H bond insertion reaction into aldehydes via 1,2-hydride shift has been well established; however, the C–C is more challenging. In presence of chiral oxazaborolidinium ion (COBI) catalyst, glyoxals was developed an 1,2-acyl for construction α-alkyl-α-formyl-β-ketoesters in high yield (up to 97%) with enantioselectivity >99%). Computational evidence indicated that noncovalent interactions (n → π*) between substrates stabilized transition state, thereby resulting enantioselectivity. This method enabled unique acyclic all-carbon quaternary stereocenters containing three different carbonyl groups.

Language: Английский

Citations

3
Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations DOI
Yungui Peng, S. Ullah,

Zulfiqar Hussain

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Diazophosphonates function as indispensable synthetic intermediates within the domain of organic chemistry, serving precursors for a diverse range molecules, with potential applications bioactive compounds. α-Diazomethylphosphonates showcase expansive reactivity and elevated levels enantioselectivity in asymmetric transformations, especially conjunction suitable catalyst systems. This review compiles latest advancements diazophosphonate chemistry from 2016 to 2024, highlighting their transformative synthesis. Diazophosphonates, regarded revolutionary compounds, exhibit unique attributes carbene precursors, driving chemical reactions such [3+2] cycloaddition, [3+3] substitution reactions. Their adaptability functional group conversions underscores pivotal role various methodologies. The highlights growing interest among chemists, fostering novel strategies expanding application horizons. multifaceted utility diazophosphonates reagents, intermediates, catalysts significance modern pharmaceutical applications, prompting further exploration into this dynamic field. 1 Introduction 2 Cycloaddition Reactions 3 Asymmetric 4 5 Substitution 6 Carbene Precursors 7 Chemistry Fluorinated Compounds 8 Other 9 Future Directions 10 Conclusion

Language: Английский

Citations

0