Lessons learnt from broad-spectrum coronavirus antiviral drug discovery DOI

Andrew A. Bolinger,

Jun Li, Xuping Xie

et al.

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: 19(9), P. 1023 - 1041

Published: July 30, 2024

Introduction Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East (MERS-CoV), and the most recent SARS-CoV-2 responsible for COVID-19 pandemic, pose significant threats to human populations over past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic distress syndromes (ARDS), resulting in high morbidity mortality.

Language: Английский

A comprehensive insight into plant-derived extracts/bioactives: Exploring their antimicrobial mechanisms and potential for high-performance food applications DOI
Hafiz Abdul Rasheed, Abdur Rehman, Aiman Karim

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 104035 - 104035

Published: April 9, 2024

Language: Английский

Citations

20
A Study of the Synergistic Effects of Essential Oils from Origanum compactum and Origanum elongatum with Commercial Antibiotics against Highly Prioritized Multidrug-Resistant Bacteria for the World Health Organization DOI Creative Commons
Aziz Drioiche, Soukayna Baammi, Khalid Zibouh

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 210 - 210

Published: April 7, 2024

The irrational use of antibiotics has favored the emergence resistant bacteria, posing a serious threat to global health. To counteract antibiotic resistance, this research seeks identify novel antimicrobials derived from essential oils that operate through several mechanisms. It aims evaluate quality and composition Origanum compactum elongatum; test their antimicrobial activity against various strains; explore synergies with commercial antibiotics; predict efficacy, toxicity, stability compounds; understand molecular interactions docking dynamic simulations. were extracted via hydrodistillation flowering tops oregano in Middle Atlas Mountains Morocco. Gas chromatography combined mass spectrometry (GC-MS) was used examine composition. Nine common chosen tested alone or combination discover synergistic effects clinically important bacterial strains. A comprehensive silico study conducted, involving dynamics simulations (MD). O. elongatum oil includes borneol (8.58%), p-cymene (42.56%), thymol (28.43%), carvacrol (30.89%), whereas is mostly composed γ-terpinene (22.89%), (15.84%), (10.21%), (E)-caryophyllene (3.63%). With proving be most potent, these showed antibacterial action both Gram-positive Gram-negative bacteria. Certain antibiotics, including ciprofloxacin, ceftriaxone, amoxicillin, ampicillin, have been shown elicit effects. fight elongatum, particularly those high (E)-caryophyllene, seem promising when antibiotics. These could result ability target same proteins facilitate access sites, as suggested by Molecular validated examined protein–ligand complexes, emphasizing propensity substances like for particular proteins, opening door potentially effective new therapeutic approaches pathogens multiple drugs.

Language: Английский

Citations

16
The State-of-the-Art Antibacterial Activities of Glycyrrhizin: A Comprehensive Review DOI Creative Commons

Ru-Yi Chen,

Jinjin Shi, Yanjun Liu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1155 - 1155

Published: June 6, 2024

Licorice (Glycyrrhiza glabra) is a plant of the genus Glycyrrhiza in family Fabaceae/Leguminosae and renowned natural herb with long history medicinal use dating back to ancient times. Glycyrrhizin (GLY), main active component licorice, serves as widely utilized therapeutic agent clinical practice. GLY exhibits diverse properties, including anti-inflammatory, antibacterial, antiviral, antitumor, immunomodulatory, intestinal environment maintenance, liver protection effects. However, current research primarily emphasizes GLY’s antiviral activity, while providing limited insight into its antibacterial properties. demonstrates broad spectrum activity via inhibiting growth bacteria by targeting bacterial enzymes, impacting cell membrane formation, altering permeability. Moreover, can also bolster host immunity activating pertinent immune pathways, thereby enhancing pathogen clearance. This paper reviews inhibitory mechanisms against various pathogenic bacteria-induced pathological changes, role high-mobility group box 1 inhibitor regulation, efficacy combating diseases caused bacteria. Furthermore, combining other antibiotics reduces minimum concentration, potentially aiding development combination therapies drug-resistant Sources information were searched using PubMed, Web Science, Science Direct, GreenMedical for keywords “licorice”, “Glycyrrhizin”, “antibacterial”, “anti-inflammatory”, “HMGB1”, combinations thereof, mainly from articles published 1979 2024, no language restrictions. Screening was carried out one author supplemented others. Papers experimental flaws their design papers that did not meet expectations (antifungal papers, etc.) excluded.

Language: Английский

Citations

9
Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies DOI Creative Commons
Asha Ripanda, Amos Luanda, Khalfani Salim Sule

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13517 - e13517

Published: Feb. 1, 2023

Galinsoga parviflora (Cav.) is a member of the Asteraceae family traditionally used for treatment various ailments such as malaria, flu, cold, colorectal cancer, liver problems and inflammation. The medicinal properties G. are due to presence secondary metabolites including flavonoids, saponins, terpenoids tannins. literature survey revealed that possesses several pharmacological antibacterial, antifungal, antioxidant antidiabetic. This review systematically discusses potential managing medical conditions. information collected from online databases Google Scholar, ScienceDirect, Springer, Web Science, Plant World Online PubMed. Among other provided in this review, ethnomedicinal uses, phytochemistry activities discussed extensively. Additonally, benefits, challenges future opportunities presented.

Language: Английский

Citations

17
Plant antibacterials: The challenges and opportunities DOI Creative Commons
Tomayo Berida, Yemi A. Adekunle,

Hannah Dada-Adegbola

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31145 - e31145

Published: May 1, 2024

Nature possesses an inexhaustible reservoir of agents that could serve as alternatives to combat the growing threat antimicrobial resistance (AMR). While some most effective drugs for treating bacterial infections originate from natural sources, they have predominantly been derived fungal and species. However, a substantial body literature is available on promising antibacterial properties plant-derived compounds. In this comprehensive review, we address major challenges associated with discovery development compounds, which acted obstacles preventing their clinical use. These encompass limited sourcing, risk agent rediscovery, suboptimal drug metabolism, pharmacokinetics (DMPK) properties, well lack knowledge regarding molecular targets mechanisms action, among other pertinent issues. Our review underscores significance these implications in quest agents. Through critical examination current state research, give valuable insights will advance our understanding classes offering potential solutions global crisis AMR.© 2017 Elsevier Inc. All rights reserved.Graphical abstractThis focuses translational antibacterials offers suggestions potentially lead more antimicrobials.

Language: Английский

Citations

8
Current advancement in nanomaterial-based emerging techniques for the determination of aminoglycosides antibiotics for antibiotic resistance surveillances DOI Creative Commons
Reena K. Sajwan,

S. Z. H. Hashmi,

Jayendra Kumar Himanshu

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(3), P. 961 - 985

Published: Jan. 1, 2024

The graphical abstract represents the nanomaterial-based sensing approach for detection of aminoglycosides (AMGs) antibiotics.

Language: Английский

Citations

7
Coumarins: Quorum Sensing and Biofilm Formation Inhibition DOI Creative Commons
Eslam R. El‐Sawy, Mohamed S. Abdel‐Aziz, Heba Abdelmegeed

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4534 - 4534

Published: Sept. 24, 2024

Quorum sensing (QS) is a bacterial cell-to-cell communication mechanism that plays an essential role in pathogenesis. QS governs behavior and controls biofilm formation, which turn contributes to antibiotic resistance. Therefore, identifying synthesizing novel compounds overcome inhibit formation are essential. Coumarins important plant-derived natural products with wide-ranging bioactivities extensive applications, including antibacterial, antifungal, anticoagulant, antioxidant, anticancer, anti-inflammatory properties. Additionally, coumarins capable of rewiring inhibition, leading higher susceptibility antimicrobial agents less this review, we aim provide overview formation. This review also discusses the synthesized controlling QS, inhibiting inducing synergy antibiotic–coumarin combinations. Hence, emphasizes potential coumarin act as antibacterial demonstrates their ability alleviate

Language: Английский

Citations

5
Ursolic and oleanolic acids: two natural triterpenoids targeting antibacterial multidrug tolerance and biofilm formation DOI Creative Commons
Chiara Spaggiari, Giannamaria Annunziato, Gabriele Costantino

et al.

Frontiers in Natural Products, Journal Year: 2024, Volume and Issue: 3

Published: Aug. 26, 2024

Natural products have been used since ancient times to treat various ailments and recognized for many years as a source of therapeutic agents structural diversity. Plant-derived thus served dietary components but also maintain state wellbeing health by preventing different diseases both inflammatory infective nature. Pentacyclic triterpenoids, particularly ursolic acid (UA) oleanolic (OA), are well-studied natural endowed with complex biological profiles. In this mini-review, we summarized the most advanced results on extraction methodologies antimicrobial activity UA OA, focusing their potential role antimicrobic adjuvants, bacterial biofilm inhibitors related mechanisms action. This offers theoretical basis inspiration further studies bioactivity mechanism.

Language: Английский

Citations

4
Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea DOI Creative Commons
Amit Raj Sharma, Gaurav Gajurel,

Salma Abdel-Karim

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 259 - 259

Published: Jan. 17, 2025

Phenolic compounds, such as stilbenes and flavonoids, from Dalea spp. exhibit diverse biological activities, including antimicrobial, anti-inflammatory, cytotoxicity properties. To this end, the objectives of study were to establish hairy root cultures D. purpurea assess its capacity produce these bioactive compounds. The co-treatment with elicitors methyl-β-cyclodextrin, magnesium chloride, methyl jasmonate, hydrogen peroxide led production secretion geranylated flavanone malheuran A, which was confirmed by mass spectrometry NMR spectroscopy analyses. highest amount (104.3 ± 6.9 mg/L) A detected at 192 h after elicitor treatment. elicited roots re-elicited for same combination elicitors, they produced a substantial (91.9 6.8 mg/L). Malheuran purified extracts culture medium, showed potent antimicrobial activity against Gram-positive bacteria, methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococci. It also demonstrated anti-inflammatory effects suppressing nitrite in LPS-stimulated RAW 264.7 macrophages. These findings show that various treatments can boost cultures, making them sustainable bioproduction platform specialized metabolite.

Language: Английский

Citations

0
Fragment optimized chalcone derivatives targeting OmpA protein as a therapeutic approach against multidrug resistant Acinetobacter baumannii DOI Creative Commons
Muhammad Naveed, Amina Abid, Tariq Aziz

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Language: Английский

Citations

0