The extract of buds of Chrysanthemum morifolium ramat alleviated UVB-induced skin photoaging by regulating MAPK and Nrf2/ARE pathways

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 332, P. 118352 - 118352

Published: May 17, 2024

Language: Английский

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New Revolution for Quality Control of TCM in Industry 4.0: Focus on Artificial Intelligence and Bioinformatics

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118023 - 118023

Published: Oct. 1, 2024

Language: Английский

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Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116067 - 116067

Published: Dec. 26, 2023

Neuropathic pain, a chronic condition with high incidence, imposes psychological burdens on both patients and society. It is urgent to improve pain management develop new analgesic drugs. Traditional Chinese medicine has gained popularity as method for relief. Diosmetin (Dio) mainly found in herbal medicines effective antioxidant, anti-cancer, anti-inflammatory properties. There are few known mechanisms underlying the effectiveness of Dio treating neuropathic pain. However, complete understanding its therapeutic effect missing.

Language: Английский

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Study on mechanism of hepatoprotective effect of Chrysanthemum morifolium Ramat. based on metabolomics with network analysis and network pharmacology

Journal of Chromatography B, Journal Year: 2023, Volume and Issue: 1222, P. 123711 - 123711

Published: April 7, 2023

Language: Английский

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JBB attenuates acute and chronic alcoholic liver injury by regulating the NFκB, KEAP1, and HIF1 pathways

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 109, P. 105782 - 105782

Published: Sept. 16, 2023

Alcoholic liver disease (ALD) is a injury caused by chronic or binge alcohol consumption. Jiubanban (JBB) 10-edible-herb- formula. The current study investigated the protective effects and mechanisms of JBB against alcoholic injury. results showed that significantly alleviated chronic-binge accelerated ethanol metabolism had effect on both acute By modulating NFκB, KEAP1, HIF1 pathways, was shown to reduce production cytokines (IL-6 TNFα), enhanced activity anti-oxidative enzymes (SOD GSH-px), reduced associated products (ROS MDA), reversing inflammation, oxidative stress, apoptosis. findings suggest this functional herbal food combination may be risk-free therapeutic strategy for treating ALD.

Language: Английский

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Comparative analysis of volatile fingerprints between different geographical origins and ornamental cultivars of white standard Chrysanthemum (Dendranthema grandiflorum)

Chemical and Biological Technologies in Agriculture, Journal Year: 2024, Volume and Issue: 11(1)

Published: March 7, 2024

Abstract Background White standard Dendranthema grandiflorum ( D. ) is widely used for ornamental purposes. The volatile organic components (VOCs) of vary depending on the geographical origin and cultivar, which influence market value. Here, we applied headspace extraction coupled with gas chromatography–mass spectrometry (HS–GC–MS) first time to determine different origins (Korea, China, Vietnam) in three genotypes (Baekgang, Jinba, Iwa-no-hakusen) based fingerprints assess correlation among metabolites identified Korean non-Korean . Results A total 41 VOCs, mainly monoterpenoids, sesquiterpenoids, alcohols, fatty acids, were identified. Principal component analysis showed that instead origin, genotype influences fingerprints. Cultivar discrimination was affected by associated alpha-terpinyl cation pathway. orthogonal partial least squares discriminant model achieved 100% 93.3% accuracies calibration validation sets, respectively. results volcano plots clustering analysis, sesquiterpenoids significantly more abundant than Korean, whereas monoterpenoids samples. Conclusions makers confirmed robustness maintenance over two years. These findings can be useful reliably identifying providing a comprehensive understanding VOCs cultivars grown countries origins. Graphical

Language: Английский

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Non-linear optical properties, Quantum Chemical Calculations, Hirschfeld Surface, Molecular Docking Study on Anticancer Activity, NCI and ELF of α-P 4 S 4 a cage phosphorus-sulphorus

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

Abstract Computational investigations on α-P 4 S , including molecular geometry optimization, Gaussian 03 software with B3LYP and MP2 methodologies was used to perform HOMO-LUMO analysis Mulliken population at the 6-311 + G(d,p) level. Hirshfeld maps two-dimensional fingerprint plots show that S⋯S, S⋯P, P⋯P interactions are most common. Second-order nonlinear optical (NLO) events interpreted by means of electrically resonant second harmonic generating. A new diagrammatic technique provides for compact mapping expected response NLO as a function molecule regards visual illustrations response. Indeed, strong electron withdrawing P group cage ring. The energy gap measured be 4.4283 eV. However, findings indicate can employed diverse opto-electronic applications. computed in good accord experimental results. finally, combining these approaches, it would possible better understand how structure its Fourier density non-covalent contribute potential anticancer activity, which could lead development more effective drugs against cancer.

Language: Английский

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The Extract of Buds of Chrysanthemum Morifolium Ramat Alleviated Uvb-Induced Skin Photoaging by Regulating Mapk and Nrf2/Are Pathways

Published: Jan. 1, 2024

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Language: Английский

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