Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi,
Journal Year:
2023,
Volume and Issue:
33(3), P. 491 - 502
Published: Sept. 11, 2023
Natural
products
have
played
a
significant
role
in
drug
discovery
and
continue
to
be
an
important
source
of
lead
for
new
drugs.
In
recent
years,
computer-based
methods
emerged
as
effective
approach
identifying
small
molecule
leads
with
desirable
pharmacokinetic
toxicity
profiles.
This
study
investigated
the
pharmacological
bioactivity
five
furofuran
lignans,
namely,
epiexcelsin,
sesamin,
sesartemin,
syringaresinol,
yangambin,
isolated
from
plant
Beilschmiedia
pulverulenta.
silico
studies
were
conducted
predict
activities,
toxicity,
likeliness
properties
compounds.
The
results
showed
that
all
compounds
had
promising
epiexcelsin
exhibiting
strong
binding
affinity
(-8.13
kcal
mol-1)
inhibitory
activity
(1.1
µM)
against
estrogen
receptor-α,
predicted
bioavailable
lead.
findings
this
provide
insights
into
potential
therapeutic
uses
natural
medicinal
plants
emphasize
combining
traditional
knowledge
modern
scientific
approaches
discovery.
Overall,
lignans
pulverulenta
represent
development
Arab Journal of Basic and Applied Sciences,
Journal Year:
2024,
Volume and Issue:
31(1), P. 454 - 469
Published: Aug. 6, 2024
A
series
of
phthalazine
derivatives
have
been
synthesized
using
green
protocol
methods
under
microwave
irradiation.
This
involved
subjecting
chlorophthalazine
to
irradiation
and
employing
various
reagents,
including
hydrazine
derivatives,
primary
secondary
amines,
active
methylene,
generate
the
novel
derivatives.
Subsequently,
a
comparison
was
made
between
yield
percentage
reaction
time
resulting
products
obtained
from
conventional
those
through
The
structures
all
new
compounds
were
confirmed
by
physical
properties
spectral
analysis.
demonstrated
significant
anticancer
activity
against
three
cancer
cell
lines
showed
promising
selectivity
when
compared
with
doxorubicin.
Compound
6
exhibited
best
activity,
IC50
1.739
µM,
0.384
1.52
µM
MCF7,
HCT116,
HepG2
lines,
respectively.
docking
results
that
drugs
exert
their
inhibiting
PARP-1.
binding
scores
in
accordance
experimental
IC50,
compound
exhibiting
score
retaining
essential
interactions
site.
our
computational
research
revealed
possess
unique
structure
effectively
inhibits
Molecules,
Journal Year:
2023,
Volume and Issue:
28(17), P. 6347 - 6347
Published: Aug. 30, 2023
Thienopyrimidines
are
structural
analogs
of
quinazolines,
and
the
creation
new
2-alkyl
derivatives
ethyl
4-aminothienopyrimidine-6-carboxylates
for
study
their
anti-proliferative
properties
is
great
pharmacological
interest.
Some
2-alkyl-4-amino-thieno[2,3-d]pyrimidines
2-5
were
synthesized,
cyto-
phototoxicity
against
BALB
3T3
cells
established
by
an
in
vitro
NRU
test.
The
obtained
results
indicate
that
tested
compounds
not
cytotoxic
or
phototoxic,
they
appropriate
to
be
studied
anti-tumor
properties.
potential
was
investigated
on
MCF-7
MDA-MB-231
cancer
cells,
as
well
a
MCF-10A
cell
line
(normal
human
mammary
epithelial
cells).
most
toxic
thienopyrimidine
3
with
IC50
13.42
μg/mL
(IC50
0.045
μM),
followed
compound
4
28.89
0.11
μM).
revealed
higher
selectivity
lower
activity
367
i.e.,
1.4
μM)
than
cells.
With
respect
ester
2
manifested
highest
effect
52.56
0.16
2-ethyl
derivative
62.86
0.24
It
estimated
substances
cycle
progression
due
arrest
G2
stage
MDA-MB-231,
while
G1
detected
estrogen
(ER)-positive
line.
compound's
effects
change
zeta
tumorigenic
utilized
this
determined.
calculation
which
we
performed
physicochemical
pharmacokinetic
parameters
influencing
biological
suggested
high
intestinal
absorption,
drug-likeness.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 22, 2023
Abstract
As
an
extension
to
our
previous
work
for
the
development
of
new
thalidomide
analogs,
current
offers
insights
into
immunomodulatory
and
anticancer
activities
quinazolinone
based
molecules
carrying
a
glutarimide
moiety.
The
findings
confirmed
some
revealed
information.
Among
newly
synthesized
compounds,
compounds
7d
12
showed
considerable
properties
in
comparison
thalidomide.
significantly
reduced
TNF-α
levels
HepG-2
cells
from
162.5
pg/mL
57.4
49.2
pg/mL,
respectively
compared
53.1
reported
Moreover,
they
caused
69.33%
77.74%
reduction
NF-κB
P65,
respectively,
60.26%
Similarly,
VEGF
432.5
161.3
132.8
153.2
two
derivatives,
also
about
8-fold
increases
caspase-8
treated
with
them.
These
results
were
slightly
better
than
those
obtained
that
Compound
had
thalidomide,
stronger
effects
on
TNF-α,
NF-B
VEGF,
caspase-8.
Accordingly,
this
indicates
compound
has
interesting
biological
should
be
further
evaluated
modified
order
develop
clinically
useful
analogs.
Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi,
Journal Year:
2023,
Volume and Issue:
33(3), P. 491 - 502
Published: Sept. 11, 2023
Natural
products
have
played
a
significant
role
in
drug
discovery
and
continue
to
be
an
important
source
of
lead
for
new
drugs.
In
recent
years,
computer-based
methods
emerged
as
effective
approach
identifying
small
molecule
leads
with
desirable
pharmacokinetic
toxicity
profiles.
This
study
investigated
the
pharmacological
bioactivity
five
furofuran
lignans,
namely,
epiexcelsin,
sesamin,
sesartemin,
syringaresinol,
yangambin,
isolated
from
plant
Beilschmiedia
pulverulenta.
silico
studies
were
conducted
predict
activities,
toxicity,
likeliness
properties
compounds.
The
results
showed
that
all
compounds
had
promising
epiexcelsin
exhibiting
strong
binding
affinity
(-8.13
kcal
mol-1)
inhibitory
activity
(1.1
µM)
against
estrogen
receptor-α,
predicted
bioavailable
lead.
findings
this
provide
insights
into
potential
therapeutic
uses
natural
medicinal
plants
emphasize
combining
traditional
knowledge
modern
scientific
approaches
discovery.
Overall,
lignans
pulverulenta
represent
development
