Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33
Published: Jan. 1, 2024
Language: Английский
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 1, 2025
Abstract Electroanalysis of melatonin, known as the sleep hormone, in presence its precursors, L‐tryptophan and 5‐hydroxy tryptophan biological matrixes is an attractive research topic. The interference voltammetric oxidation signals these compounds, which have similar chemical structures, causes their determination to be challenging. This project aims conduct a real‐time electroanalysis melatonin precursors samples using novel nanocomposite platform. new platform incorporates multi‐walled carbon nanotubes (MWCNTs), gold nanoparticles (GNPs), graphitic nitrides (g‐C 3 N 4 ) placed on glassy electrode surface. peak can effectively separated from other this Thus, easily determined electrochemically precursors. In optimized conditions, electroanalytical method displayed linear response range between 5.0 × 10 −7 1.0 −5 mol/L for both −8 −6 L‐tryptophan. Furthermore, proposed modified was successfully applied determine various real such human plasma, urine, pharmaceutical formulations. sensor revealed excellent precision, remarkable simplicity, acceptable selectivity, good reproducibility, long‐term stability, rapid toward L‐tryptophan, matrixes.
Language: Английский
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Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 569, P. 120160 - 120160
Published: Jan. 30, 2025
Language: Английский
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Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 393 - 424
Published: Jan. 1, 2025
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0
Published: Jan. 1, 2025
Language: Английский
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Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120221 - 120221
Published: Feb. 1, 2025
Language: Английский
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Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 631 - 645
Published: Jan. 1, 2025
Language: Английский
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Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)
Published: March 18, 2025
Abstract The escalating global prevalence of allergies presents a substantial public health challenge. Immunoglobulin E (IgE) serves as key biomarker for allergic diseases, often measured in blood serum by ELISA immunoassays. Despite recent interest minimally invasive sampling biological fluids, the low sample volumes and IgE concentrations demand highly sensitive methodologies, typically confined to centralized laboratories. In this article, decentralizable approach based on competitive immunoassays using Pd nanocluster (PdNCs)-labelled antibodies electrochemical detection is proposed. With aim, PdNCs were successfully bioconjugated with an anti-hIgE antibody perform To improve analytical capabilities methodology, disposable screen-printed carbon electrodes dual working used enhancing precision. Prior electrodeposition at − 0.6 V 90 s significantly improved sensitivity (7.1 µA g ng⁻ 1 ) lowered limit (LoD) 0.3 ng g⁻ determination. use labels resulted improvement LoD Calibration curves performed determination, ranging from 10 −5 2 −1 , demonstrated comparable high-tech methods, 0.008 measurements. Bimodal (linear sweep voltammetry inductively coupled plasma–mass spectrometry) various fluids (saliva, tears, nasal exudate, capillary blood, serum) revealed significant differences levels between non-allergic individuals. Notably, correlated strongly certain correlation has also been found exudate. approach, combining precision non-invasive sampling, offers simplified alternative determination disease. Graphical
Language: Английский
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ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
An electrochemical sandwich immunoassay was fabricated to measure the prostate-specific antigen (PSA) biomarker. The PSA immunosensor developed by altering surface of a glassy carbon electrode (GCE) with nanocomposite comprising carboxyl-functionalized dots that support gold nanoparticles (AuNPs), which were then combined hydroxylated boron nitride nanosheets (HO-BN). This construction possesses distinctive signal enhancement characteristics and prepared via facile method. Considering high biological affinity AuNPs for biomolecules, (CDs) carboxyl (COOH) groups make suitable substrate modification. alteration allows antibody (Ab1) attachment, resulting in sandwich-like configuration. Additionally, dot-stabilized integrated into HO-BN nanosheet nanocomposites considerably boost electron transfer rate, leading remarkable potential sensor applications. By utilizing horseradish peroxidase (HRP)-conjugated antifree (Ab2), reduction hydrogen peroxide (H2O2) achieved within cell. led increased current, attributed concentration, is required biosensor analysis perform properly. revealed linear correlation concentrations ranging from 1.0 3500 pg mL-1, achieving low detection limit 0.136 mL-1. Furthermore, aptasensor demonstrates excellent selectivity, stability, commendable reproducibility, indicating its significant clinical research diagnostic
Language: Английский
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Ingeniería y Competitividad, Journal Year: 2025, Volume and Issue: 27(1)
Published: March 20, 2025
Introducción: El cáncer es una de las principales causas mortalidad a nivel mundial, y su detección temprana mejora tasas supervivencia. Los métodos convencionales son costosos, invasivos largo tiempo análisis. biosensores electroquímicos surgen como alternativa eficiente para detectar biomarcadores forma rápida precisa.Objetivo: Revisar el uso nanomateriales carbono en la del cáncer, destacando sus propiedades, ventajas desafíos aplicaciones biomédicas.Metodología: Se realizó búsqueda Scopus Web of Science artículos publicados desde 2018 inglés. usaron ecuaciones con términos clave se aplicaron filtros inclusión exclusión. estudios seleccionados fueron organizados analizados sistemáticamente según tipo nanomaterial utilizado.Resultados: mejoran sensibilidad selectividad los electroquímicos, permitiendo muy bajas concentraciones. grafeno óxido reducido destacan por alta conductividad facilidad funcionalización.Conclusiones: La incorporación contribuye cáncer. Sin embargo, requiere más investigación al respecto mejorar tecnología lograr traslado entornos clínicos.
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Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 163347 - 163347
Published: April 1, 2025
Language: Английский
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0