Properties of Cross‐Linked Poly‐l‐lysine Hydrogels across the Random Coil–Helix Transition DOI Creative Commons
Kathryn G. Wilcox, Alexandra Grinevich, Adam Linscott

et al.

Macromolecular Chemistry and Physics, Journal Year: 2023, Volume and Issue: 224(24)

Published: Sept. 28, 2023

Abstract Hydrogels are key components of biological tissues and have applications in biomedicine commercial industry. Many known to strain harden due the semiflexible nature chains. Here, mechancial properties poly‐ l ‐lysine (PLL) hydrogels, whose network chains undergo a random coil–helix transition, studied as function polypeptide's structural changes. PLL is cross‐linked with poly(ethylene glycol)diglycidyl ether at cross‐link percents ranging from 3% 6%. The conformation change mechanical investigated circular dichroism small large amplitude oscillatory shear rheology, respectively. As pH low percents, transition softening hardening observed become helical that similar behavior filamentous gels consistent recent theoretical descriptions hardening. At higher densities, hydrogels brittle stress concentration inhomogeneous locations network, which dynamic light scattering. Overall, has significant effect on nonlinear hydrogels. By understanding hydrogel structure response environmental changes, their potential can be expanded functional biomedical materials.

Language: Английский

Biomimetic strain-stiffening in fully synthetic dynamic-covalent hydrogel networks DOI Creative Commons
Rachel C. Ollier, Yuanhui Xiang,

Adriana M. Yacovelli

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(18), P. 4796 - 4805

Published: Jan. 1, 2023

Strain-stiffening is observed and characterized in flexible PEG hydrogel networks crosslinked via dynamic-covalent boronate ester bonds, revealing an uncommon synthetic mimic of a mechanoresponse found natural biopolymer networks.

Language: Английский

Citations

35
Peptide Stereochemistry Effects from pKa-Shift to Gold Nanoparticle Templating in a Supramolecular Hydrogel DOI
Simone Adorinni,

Serena Gentile,

Ottavia Bellotto

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3011 - 3022

Published: Jan. 18, 2024

The divergent supramolecular behavior of a series tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic, and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading hydrogels or crystals, respectively. Despite the similarity between peptides' turn conformations, stereoconfiguration led different abilities engage in intramolecular hydrogen bonding. Self-assembly further shifted pKa value C-terminal side chain. As result, across pH range 4–6, only one epimer predominated sufficiently as zwitterion reach critical molar fraction, allowing gelation. By contrast, differing values higher dipole moment other favored crystallization. four tested for gold nanoparticle (AuNP) formation, with hydrogel being key control stabilize AuNPs, yielding nanocomposite that catalyzed photodegradation dye. Importantly, AuNP formation occurred without use reductants than peptide, redox chemistry investigated by LC–MS, NMR, infrared scattering-type near field optical microscopy (IR s-SNOM). This study provides important insights rational design simple peptides minimalistic green building blocks functional nanocomposites.

Language: Английский

Citations

12
Hydrogel Toughening Resets Biomedical Application Boundaries DOI

Yitian Teng,

Jiayu Chi,

Jinjian Huang

et al.

Progress in Polymer Science, Journal Year: 2025, Volume and Issue: unknown, P. 101929 - 101929

Published: Jan. 1, 2025

Language: Английский

Citations

1
Structure and applications of PIC-based polymers and hydrogels DOI Creative Commons
Kaizheng Liu, Johannes Vandaele, Hongbo Yuan

et al.

Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(2), P. 101834 - 101834

Published: Feb. 1, 2024

Over the last decade, water-soluble polyisocyanopeptides (PICs) have emerged as a new class of biomimetic polymers. Analogous to biopolymers, PICs exhibit semi-flexible nature; however, unlike their biological counterparts, they possess unique advantage being highly customizable. Hydrogels made fibrous and porous architecture and, consequently, mechanical properties. This includes strain stiffening, which is well known in materials but rarely found synthetic gels. These properties make PIC hydrogels uniquely suited for wide range applications. One key application use tailorable, 3D cell culture matrix, also allows investigating interactions between cells environment. Beyond gel applications, soluble are used an immunological setting, where provide multivalent scaffold development dendritic cells. review aims comprehensive overview PICs, encompassing structure, properties, First, we discuss history, synthesis, characterization methods hydrogels, followed by current applications that from biosensing immunotherapy wound healing. Presenting these different demonstrate polymers multi-versatile scaffold, triggering interest material scientists, biologists, chemists, medical engineers.

Language: Английский

Citations

7
Fabrication and application of multifunctional conductive hydrogel film for wearable sensors via efficient freeze-thaw cycling and annealing process DOI

Yanghan Sun,

Yajun Xie,

Hanyan Zou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153487 - 153487

Published: June 30, 2024

Language: Английский

Citations

7
Skin-Inspired Patterned Hydrogel with Strain-Stiffening Capability for Strain Sensors DOI

Jianbing Cui,

Ruisheng Xu,

Weifu Dong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(41), P. 48736 - 48743

Published: Oct. 9, 2023

Flexible materials with ionic conductivity and stretchability are indispensable in emerging fields of flexible electronic devices as sensing protecting layers. However, designing robust skin-like compliance remains challenging because the contradiction between softness strength. Herein, inspired by modulus-contrast hierarchical structure biological skin, we fabricated a biomimetic hydrogel strain-stiffening capability embedding stiff array poly(acrylic acid) (PAAc) soft polyacrylamide (PAAm) hydrogel. The stress distribution both domains can be regulated changing arrangement patterns, thus improving mechanical properties patterned As expected, resulting showed its nonlinear properties, which afforded high strength 1.20 MPa while maintaining low initial Young's modulus 31.0 kPa. Moreover, PAAc enables to possess protonic absence additional salts, endowing ability serve strain sensor for monitoring human motion.

Language: Английский

Citations

11
Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacement DOI Creative Commons
Ivo Anton Octave Beeren, Francis L. C. Morgan, Timo Rademakers

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(35), P. 24330 - 24347

Published: Aug. 20, 2024

Dynamic hydrogels are attractive platforms for tissue engineering and regenerative medicine due to their ability mimic key extracellular matrix (ECM) mechanical properties like strain-stiffening stress relaxation while enabling enhanced processing characteristics injectability, 3D printing, self-healing. Systems based on imine-type dynamic covalent chemistry (DCvC) have become increasingly popular. However, most reported polymers comprising aldehyde groups either end-group-modified synthetic or side-chain-modified natural polymers; versions of noticeably absent. To facilitate access new classes hydrogels, we report the straightforward synthesis a water-soluble copolymer with tunable fraction pendant (12-64%) using controlled radical polymerization formation into hydrogel biomaterials cross-links. We found polymer be well-controlled determined reactivity ratios consistent blocky gradient microarchitecture. Subsequently, observed fast gelation kinetics cross-linking. were able vary stiffness from ≈2 20 kPa, tune onset toward biologically relevant regime (σ

Language: Английский

Citations

4
Edible Jumpers Powered by Shell Snapping DOI Creative Commons
Bokeon Kwak,

Juliette Hars,

Dario Floreano

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Food animation is gaining increasing attention for the ability to reduce waste and increase attractiveness in animals humans. Although several examples of food methods have been recently described, speed range motion are still limited. Here a method described design manufacture small edible jumpers powered by rapid release elastic energy through shell snapping. The jumping actuators made gelatin crosslinked with genipin polyvinyl alcohol, ensuring resilience stress during eversion. shape size shells modeled optimized maximum height resulting diameter 47 mm that can reach 361 mm. be loaded additional nutritional components encapsulated humidity‐sensitive latches automatic release. To showcase potential uses such jumpers, pellet pets an animated dessert humans described.

Language: Английский

Citations

0
Modeling the crack propagation of ductile fibril reinforced polymer membrane with the consideration of drawing fibrils DOI
Xiangyang Zhou, Diankai Qiu, Zhutian Xu

et al.

Journal of the Mechanics and Physics of Solids, Journal Year: 2025, Volume and Issue: unknown, P. 106118 - 106118

Published: March 1, 2025

Language: Английский

Citations

0
Multifunctional Recyclable Electronic Skins Enabled by Hierarchical Dynamic Network Structures DOI Open Access
Xiaohui Yu,

Choon Peng Teng,

Jayven Chee Chuan Yeo

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Inspired by the sensory functions of human skin, development electronic skins (e‐skins) has garnered significant attention. Ionogels, as an emerging class soft materials, show promise in serving e‐skins. The pursuit a sustainable society motivates recyclable ionogels, typically achieved introducing dynamic non‐covalent bonds. However, these current state‐of‐the‐art methods often result poor elasticity or strain softening, which significantly limits their suitability for e‐skin applications. This study introduces multifunctional and based on hierarchical double‐network ionogel that integrates covalent bonds interactions. seamlessly key including strain‐stiffening capability, self‐healing ability within 12 h, rapid response time (120 ms), high (energy loss coefficient 0.07 at 150% strain), all single material. enhance cohesive energy, ensuring elasticity, while improve adhesive properties. As proof concept, can be fabricated into strain‐temperature dual‐modal e‐skin, exhibiting sensitivity, reliability, state‐independent performance. advancement highlights potential ionogels next‐generation wearable devices.

Language: Английский

Citations

0