Carbon Monoxide in Healthcare Monitoring Balancing Potential and Challenges in Public Health Perspective: A Narrative Review DOI Open Access

Velpukonda Mounika Laddunoori Mounika,

K P Indumathi,

Sibyl Siluvai

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Carbon monoxide (CO) has medicinal potential and harmful qualities. However, excessive exposure to CO can lead severe organ failure. is exogenously endogenously generated within the human body. Ongoing research aims uncover beneficial aspects of CO. It serves as a biomarker for inflammation other serious illnesses. Preclinical trials exploring CO's application have indicated benefits in addressing conditions such Ischemia, Tendonitis, Neuropathic pain, even cancer therapy. Cardiovascular disease emerges particularly promising target therapy due its potent vasodilatory effects. While into CO-based therapeutics shown promise experimental preclinical settings, clinical translation widespread adoption remain early stages. This review will illuminate advantageous role alongside obstacles challenges associated with implementation.

Language: Английский

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy DOI Creative Commons

Xumeng Wu,

Ziqi Zhou, Kai Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

Citations

27
Hydrogen sulfide (H2S) metabolism: Unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine DOI
Tejasvi Pandey, Vivek Pandey

Nitric Oxide, Journal Year: 2024, Volume and Issue: 144, P. 20 - 28

Published: Jan. 17, 2024

Language: Английский

Citations

23
Gas-assisted phototherapy for cancer treatment DOI
Jun Zhou, Chen Cao, Xinlu Zhang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 564 - 577

Published: July 14, 2023

Language: Английский

Citations

26
Current paradigms in employing self-assembled structures: Drug delivery implications with improved therapeutic potential DOI
Ajay Sharma, Manoj Singh, Varruchi Sharma

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113745 - 113745

Published: Jan. 5, 2024

Language: Английский

Citations

8
Polyprodrug nanomedicine for chemiexcitation-triggered self-augmented cancer chemotherapy and gas therapy DOI
Qingfu Wang, Chen Zhang,

Ya Zhao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122606 - 122606

Published: May 9, 2024

Language: Английский

Citations

5
In Vitro CO-Releasing and Antioxidant Properties of Sulfonamide-Based CAI-CORMs in a H2O2-Stimulated Human Achilles Tendon-Derived Cell Model DOI Creative Commons
Emanuela Berrino, Paolo Guglielmi, Fabrizio Carta

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 593 - 593

Published: Jan. 28, 2025

Tendinopathy is often described as a complex and multifactorial condition which affects tendons. Tendon disorders are marked by reduction in mechanical function, accompanied pain swelling. At the molecular level, tendinopathy leads to oxidative stress-driven inflammation, increased cell death, disruption of extracellular matrix balance, abnormal growth capillaries arteries, degeneration collagen formation. Here, we report an innovative approach modulate stress during based on sulfonamide-based Carbonic Anhydrase Inhibitors—carbon monoxide releasing molecules (CAI–CORMs) hybrids endowed with dual carbon (CO) activity carbonic anhydrase (CA) inhibition. The synthesised compounds have been studied model human Achilles tendon-derived cells stimulated H2O2. Among library, compound 1c and, greater extent, 1a, showed be extremely effective terms restoration metabolic proliferation due their capacity release CO inhibit CA isoforms involved inflammatory processes nanomolar range. Moreover, 1a can restore type 1 secretion under pro-oxidant conditions.

Language: Английский

Citations

0
sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy DOI

Kai‐Yue Song,

Ming Jiang, Bailong Tao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113580 - 113580

Published: Feb. 28, 2025

Language: Английский

Citations

0
Enhancing melanoma therapy with hydrogel microneedles DOI Creative Commons
Leilei Zhu,

Ge Qiao,

Hongwei Gao

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 17, 2025

Melanoma is highly invasive and resistant to conventional treatments, accounting for nearly 75% of skin cancer-related deaths globally. Traditional therapies, such as chemotherapy immunotherapy, often exhibit limited efficacy are associated with significant side effects due systemic drug exposure. Microneedles (MNs), an emerging delivery system, offer multiple advantages, including safety, painlessness, minimal invasiveness, controlled release. Among these, hydrogel microneedles (HMNs) stand out their extracellular matrix-like structure swelling-induced continuous channels, which enable the direct therapeutic agents into tumor microenvironment (TME). This approach enhances bioavailability while reducing toxicity, establishing HMNs a promising platform melanoma treatment. review highlights recent advancements in therapy, focusing on applications biomarker extraction early diagnosis role supporting multimodal treatment strategies, chemotherapy, phototherapy, targeted combination therapy. Furthermore, current matrix materials fabrication techniques discussed. Finally, limitations critically analyzed, recommendations future research development provided.

Language: Английский

Citations

0
Recent advances in the application of gasotransmitters in spinal cord injury DOI Creative Commons
Xiang Gao,

Bing-rong Jin,

Xiaozhong Zhou

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 23, 2024

Abstract Spinal Cord Injury (SCI) is a condition characterized by complete or incomplete motor and sensory impairment, as well dysfunction of the autonomic nervous system, caused factors such trauma, tumors, inflammation. Current treatment methods primarily include traditional approaches like spinal canal decompression internal fixation surgery, steroid pulse therapy, newer techniques stem cell transplantation brain-spinal cord interfaces. However, above have limited efficacy in promoting axonal neuronal regeneration. The challenge medical research today lies neuron regeneration regulating disrupted microenvironment cord. Studies shown that gas molecular therapy increasingly used research, with gasotransmitters hydrogen sulfide, nitric oxide, carbon monoxide, oxygen, exhibiting neuroprotective effects central system diseases. protect against death reshape injuries oxidative, inflammatory apoptotic processes. At present, mainly relies on inhalation for systemic administration, which cannot effectively enrich release injury area, making it difficult to achieve expected effects. With rapid development nanotechnology, use nanocarriers targeted enrichment precise control at Sites has become one emerging directions SCI. It promising therapeutic preclinical studies bring new hope opportunities In this review, we will briefly outline progress nanogas Graphical

Language: Английский

Citations

3
Multifunctional Adaptable Injectable TiN‐Based Hydrogels for Antitumor and Antidrug‐Resistant Bacterial Therapy DOI

Jianghao Xing,

Jie Shan,

Haowei Xue

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

The close relationship between bacteria and tumors has recently attracted increasing attention, an number of resources are being invested in the research development biomedical materials designed for treatment both. In this study, prefabricated TiN nanodots (NDs) Fe(CO)

Language: Английский

Citations

3