ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(42), P. 48952 - 48962
Published: Oct. 16, 2023
Excessive
oxidative
stress,
bacterial
infections,
and
inflammation
are
the
primary
factors
impeding
healing
of
skin
wounds.
Bioactive
hydrogels
commonly
employed
in
treatment
injuries.
However,
limited
solubility
many
drugs
active
agents
water
significantly
hampers
their
effectiveness
hydrogel
dressings.
In
this
research,
prior
to
incorporation
into
silk
fibroin
(SF)
matrix,
two
curcumin
silver
nanoparticles
(Ag
NPs)
were
decorated
by
sericin
improve
dispersibility
stability
water.
The
resultant
SF/Ag/C
combined
biological
safety
nontoxicity
SF,
antioxidant
anti-inflammatory
efficacy
curcumin,
antibacterial
effect
Ag
NPs.
These
properties
effectively
enhanced
wound
repair
reducing
mitigating
suppressing
expression
pro-inflammatory
factors,
promoting
angiogenesis.
This
study
presented
a
straightforward
approach
for
constructing
bioactive
promotion
process.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101553 - 101553
Published: Feb. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Cyborg and Bionic Systems,
Journal Year:
2023,
Volume and Issue:
4
Published: Jan. 1, 2023
Everyday
unnatural
events
such
as
trauma,
accidents,
military
conflict,
disasters,
and
even
medical
malpractice
create
open
wounds
massive
blood
loss,
which
can
be
life-threatening.
Fractures
large
bone
defects
are
among
the
most
common
types
of
injuries.
Traditional
treatment
methods
usually
involve
rapid
hemostasis
wound
closure,
convenient
fast
but
may
result
in
various
complications
nerve
injury,
deep
infection,
vascular
hematomas.
To
address
these
complications,
studies
have
been
conducted
on
new
materials
that
degraded
body
reduce
inflammation
abscesses
surgical
area.
This
review
presents
latest
research
progress
biomaterials
for
repair.
The
mechanisms
healing
first
introduced
then
principles
rational
design
summarized.
After
providing
representative
examples
hemostatic
repair,
future
challenges
opportunities
field
proposed.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 3, 2024
Abstract
Gelatin-methacryloyl
(GelMA)
is
a
highly
adaptable
biomaterial
extensively
utilized
in
skin
regeneration
applications.
However,
it
frequently
imperative
to
enhance
its
physical
and
biological
qualities
by
including
supplementary
substances
composition.
The
purpose
of
this
study
was
fabricate
characterize
bi-layered
GelMA-gelatin
scaffold
using
3D
bioprinting.
upper
section
the
encompassed
with
keratinocytes
simulate
epidermis,
while
lower
included
fibroblasts
HUVEC
cells
mimic
dermis.
A
further
step
involved
addition
amniotic
membrane
extract
(AME)
order
promote
angiogenesis.
incorporation
gelatin
into
GelMA
found
stability
mechanical
qualities.
While
Alamar
blue
test
demonstrated
that
high
concentration
(20%)
resulted
decrease
cell
viability,
live/dead
staining
revealed
AME
increased
quantity
viable
HUVECs.
Further,
upregulated
expression
KRT10
VIM
fibroblasts.
Additionally,
histological
results
formation
well-defined
layers
creation
extracellular
matrix
(ECM)
GelMA/gelatin
hydrogels
during
14-day
culture
period.
Our
showed
3D-bioprinted
composite
comprising
GelMA,
gelatin,
can
be
used
regenerate
tissues.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
243, P. 113091 - 113091
Published: June 14, 2024
Amidst
the
rapid
advancements
in
materials
science,
exploration
of
aerogel-based
biomaterials
has
garnered
extensive
attention
across
diverse
sectors,
including
biomedicine,
energy,
architecture,
and
sensing.
Comprehensive
studies
have
unveiled
utilization
organic,
inorganic,
hybridized
for
aerogel
preparation,
catapulting
to
global
prominence.
Endowed
with
distinctive
properties,
low
density,
a
hierarchical
porous
network,
high
porosity,
nanoscale
micropores,
aerogels
exhibited
broad
spectrum
applications,
particularly
realm
tissue
engineering.
The
deployment
engineering
is
dynamic
phase
development,
available
reports
indicating
varying
degrees
fields
such
as
blood
vessels,
soft
tissues,
nerves,
skin,
muscles,
heart,
bronchial
tubes,
bone,
cartilage—an
evolutionary
process.
This
paper
offers
comprehensive
review
evolution
properties
preparation
processes,
encapsulating
strategic
insights
application
It
succinctly
summarizes
recent
developments
research,
emphasizing
their
significance.
Additionally,
outlines
future
prospects
envisions
challenges
arising
from
current
studies.
Through
this
thorough
engineering,
aspires
make
profound
impact
on
regenerative
medicine,
offering
innovative
effective
strategies
biomedicine.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(4), P. 042001 - 042001
Published: July 4, 2024
Skin
is
the
largest
organ
of
human
body
which
plays
a
critical
role
in
thermoregulation,
metabolism
(e.g.
synthesis
vitamin
D),
and
protection
other
organs
from
environmental
threats,
such
as
infections,
microorganisms,
ultraviolet
radiation,
physical
damage.
Even
though
skin
diseases
are
considered
to
be
less
fatal,
ubiquity
irritation
caused
by
them
highlights
importance
studies.
Furthermore,
promising
means
for
transdermal
drug
delivery,
requires
thorough
understanding
structure.
Current
animal
andin
vitrotwo/three-dimensional
models
provide
platform
disease
studies
testing,
whereas
they
face
challenges
complete
recapitulation
dynamic
complex
structure
actual
tissue.
One
most
effective
methods
testing
pharmaceuticals
modeling
skin-on-a-chip
(SoC)
platforms.
SoC
technologies
non-invasive
approach
examining
3D
layers
artificially
creating
order
develop
diagnostic
or
therapeutic
methods.
In
addition,
enable
perfusion
culture
medium
with
nutrients
facilitate
continuous
removal
cellular
waste
further
mimic
thein
vivocondition.
Here,
article
reviews
recent
advances
design
applications
platforms
well
analysis
drugs
cosmetics.
By
contributions
different
patents
physiological
relevance
models,
review
underscores
significant
shift
towards
more
ethical
efficient
alternatives
testing.
it
explores
market
dynamics
ofin
vitroskin
organ-on-a-chip
platforms,
discussing
impact
legislative
changes
demand
on
development
adoption
these
advanced
research
tools.
This
also
identifies
existing
obstacles
that
hinder
advancement
proposing
directions
future
improvements,
particularly
focusing
journey
clinical
adoption.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(7), P. 105820 - 105820
Published: May 1, 2024
Biomedical
applications
of
herbals
and
their
derivatives
for
skin
tissue
engineering
have
become
increasingly
popular
in
recent
years.
Herbals
can
be
used
to
create
scaffolds
wound
healing,
as
they
provide
a
biocompatible
biodegradable
structure
that
promote
regeneration.
In
the
literature
search
relevant
papers,
sixty-eight
studies
been
included
from
January
2000
September
2023
PubMed
Google
Scholar
database
sources.
This
review
provided
an
overview
current
knowledge
on
biomedical
herbal
medicine
such
Aloe
Vera,
Calendula
Officinalis,
Hypericum
perforatum,
Lawsonia
inermis,
Nicotine,
Propolis,
Honey,
Perovskia
abrotanoides
Karel,
Oak
fruit
inner,
Lithospermum
officinale,
engineering.
We
showed
is
prominent
therapeutic
strategy
cost-effective
treatment
wounds
by
applying
different
natural
products,
nanotechnology,
material
science,
regenerative
suit
care
demands
repair,
restoration
lost
integrity
scarless
healing.
So
design,
synthesis,
modification,
evaluation,
characterization
products
are
needed
target
New
strategies
based
drug
delivery
systems
nanocarriers
nanofibers,
nanoparticles,
vesicular
structures,
materials
gelatin,
PCL,
collagen,
chitosan,
PLGA,
PEG,
PEO,
PVA,
gums,
PU
also
developed
facilitate
healing
process.
The
homeostasis,
re-epithelialization,
regeneration,
immunocytes
investigated
inducing
fibroblasts
proliferation
and/or
collagen
production.
Nevertheless,
further
clinical
before
introducing
commercial
market.
Materials Advances,
Journal Year:
2024,
Volume and Issue:
5(12), P. 4996 - 5024
Published: Jan. 1, 2024
This
review
aims
to
provide
a
comprehensive
overview
of
the
current
trends,
advantages,
challenges,
and
future
directions
in
field
bionanocomposites
for
skin
tissue
repair
regeneration.
