Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Abstract
Osteoarthritis
(OA)
is
an
inflammatory
and
progressive
joint
disease
characterized
by
angiogenesis‐mediated
sustained,
chronic,
low‐grade
synovitis.
Anti‐angiogenesis
emerging
as
a
strategy
for
attenuating
OA
progression,
but
often
compromised
poor
targeted
drug
delivery
immune
clearance.
Recent
studies
have
identified
macrophages
formed
“protective
barrier”
in
the
lining
layer
(LL)
of
synovium,
which
blocked
communication
cavity
sublining
(SL)
synovium.
Inspired
natural
mimicry,
macrophage
membrane‐camouflaged
explored
to
avoid
Based
on
single
cell
RNA
sequencing,
CD34
+
synovial
cells
are
“sentinel
cells”
synovium
angiogenesis.
Consequently,
antibody‐modified
membrane
constructed
target
new
Hence,
biomimetic
multi‐layered
nanoparticle
(NP)
developed
that
incorporates
axitinib‐loaded
poly(lactic‐co‐glycolic)
acid
(PLGA)
with
antibody
modified
(Atb@NP@Raw@CD34)
specifically
deliver
axitinib
(Atb)
SL
sustain
inhibiting
angiogenesis
without
elimination.
It
found
Atb@NP@Raw@CD34
can
pass
through
“barrier”,
targeting
cells,
continuously
releasing
Atb
anti‐angiogenesis
Furthermore,
vivo
data
demonstrated
attenuate
degeneration
In
conclusion,
local
injection
presents
promising
approach
clinically
impeding
progression.
Journal of Macromolecular Science Part A,
Journal Year:
2024,
Volume and Issue:
61(7), P. 493 - 502
Published: June 3, 2024
The
work
aims
to
develop
a
biopolymer-dextrin-based
three-dimensional
crosslinked
hydrophilic
material
for
antimicrobial
delivery.
copolymer
(Dxt-PNVA)
has
been
prepared
by
in-situ
grafting
of
poly(N-vinylacetamide),
followed
cross-linking
with
N,N'-methylenebisacrylamide
dextrin.
By
varying
the
concentrations
reactants,
an
optimized
(Dxt-PNVA
5)
lowest
%
crosslinking
chosen
biomedical
applications.
copolymeric
gel
characterized
in
detail
using
various
techniques,
its
cytocompatibility
study
HeLa
Cell
lines
that
confirm
cytocompatible
nature
material.
Copolymeric
is
suitable
effective
release
two
antimicrobials
(amoxicillin
trihydrate
and
ornidazole)
from
tablet
formulation
prolonged
period
24
h.
obtained
data
demonstrates
hydrogel
potential
characteristics
daily
dose
administration
amoxicillin
ornidazole.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(28), P. 13613 - 13626
Published: Jan. 1, 2024
Over
the
past
several
years,
a
significant
increase
in
expanding
field
of
biomaterial
sciences
has
been
observed
due
to
development
biocompatible
materials
based
on
peptide
derivatives
that
have
intrinsic
therapeutic
potential.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Hydrogel
films
were
prepared
using
mucoadhesive
extracts
from
fenugreek
and
flax
seeds,
their
versatility
for
a
range
of
biological
uses
–
such
as
anti-inflammatory,
anti-diabetic,
anti-oxidant,
anti-microbial
applications
was
examined.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(20), P. 2882 - 2882
Published: Oct. 12, 2024
Corneal
endothelial
dysfunction
is
a
leading
cause
of
vision
loss
globally,
frequently
requiring
corneal
transplantation.
However,
the
limited
availability
donor
tissues,
particularly
in
developing
countries,
has
spurred
on
exploration
tissue
engineering
strategies,
with
focus
polymer
biomaterials
as
scaffolds
for
endotlhelium
regeneration.
This
review
provides
comprehensive
overview
advancements
biomaterials,
focusing
their
role
supporting
growth,
differentiation,
and
functional
maintenance
human
cells
(CECs).
Key
properties
scaffold
materials,
including
optical
clarity,
biocompatibility,
biodegradability,
mechanical
stability,
permeability,
surface
wettability,
are
discussed
detail.
The
also
explores
latest
innovations
micro-
nano-topological
morphologies,
fabrication
techniques
such
electrospinning
3D/4D
bioprinting,
integration
drug
delivery
systems
into
scaffolds.
Despite
significant
progress,
challenges
remain
translating
these
technologies
to
clinical
applications.
Future
directions
research
highlighted,
need
improved
biomaterial
combinations,
deeper
understanding
CEC
biology,
development
scalable
manufacturing
processes.
aims
serve
resource
researchers
clinician–scientists
seeking
advance
field
endothelium
engineering.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Abstract
Osteoarthritis
(OA)
is
an
inflammatory
and
progressive
joint
disease
characterized
by
angiogenesis‐mediated
sustained,
chronic,
low‐grade
synovitis.
Anti‐angiogenesis
emerging
as
a
strategy
for
attenuating
OA
progression,
but
often
compromised
poor
targeted
drug
delivery
immune
clearance.
Recent
studies
have
identified
macrophages
formed
“protective
barrier”
in
the
lining
layer
(LL)
of
synovium,
which
blocked
communication
cavity
sublining
(SL)
synovium.
Inspired
natural
mimicry,
macrophage
membrane‐camouflaged
explored
to
avoid
Based
on
single
cell
RNA
sequencing,
CD34
+
synovial
cells
are
“sentinel
cells”
synovium
angiogenesis.
Consequently,
antibody‐modified
membrane
constructed
target
new
Hence,
biomimetic
multi‐layered
nanoparticle
(NP)
developed
that
incorporates
axitinib‐loaded
poly(lactic‐co‐glycolic)
acid
(PLGA)
with
antibody
modified
(Atb@NP@Raw@CD34)
specifically
deliver
axitinib
(Atb)
SL
sustain
inhibiting
angiogenesis
without
elimination.
It
found
Atb@NP@Raw@CD34
can
pass
through
“barrier”,
targeting
cells,
continuously
releasing
Atb
anti‐angiogenesis
Furthermore,
vivo
data
demonstrated
attenuate
degeneration
In
conclusion,
local
injection
presents
promising
approach
clinically
impeding
progression.
