Metabolism and retention of verapamil dictate microneedle-based drug delivery: analytical and numerical study DOI

Tanmoy Bhuimali,

Sarifuddin Sarifuddin,

Prashanta Kumar Mandal

et al.

Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences, Journal Year: 2024, Volume and Issue: 480(2304)

Published: Dec. 1, 2024

This study systematically investigates, both analytically and numerically, transdermal drug delivery using a microneedle (MN) array. The released from the MN tip disperses through viable skin before being absorbed in blood compartment. Reversible uptake kinetics between tissue compartments, together with reversible specific binding of its receptors tissue, have been taken into account. governing equations are solved numerically an explicit manner. Simulations predict that metabolism skin, irreversible stabilizing effect on free bound verapamil concentrations. In addition, longer larger skin–blood interface area contribute to higher concentrations all forms compartments. results suggest lack compartment might overestimate verapamil. A thorough sensitivity analysis has performed account for uncertainties some parameters involved. retention relationship length MN, time application, interface, rate compartments constitute novel aspect this analytical numerical work. Our reduced model is excellent agreement available literature.

Language: Английский

Research progress and application exploration of typical microreactor technologies for health monitoring and disease Diagnosis/Treatment DOI

Zhongjian Tan,

Yun Zheng, Huanhuan Shi

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155938 - 155938

Published: Sept. 1, 2024

Language: Английский

Citations

3
Recent advances in gold nanostructure-based biosensors in detecting diabetes biomarkers DOI Creative Commons

Tahereh Jamshidnejad-Tosaramandani,

Soheila Kashanian, Kobra Omidfar

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 17, 2024

Diabetes mellitus (DM) is a prevalent disorder with an urgent need for continuous, precise, and on-site biomarker monitoring devices. The continuous of DM biomarkers from different biological matrices will become routine in the future, thanks to promising biosensor design. Lately, employing nanomaterials receptor parts has had great impact on smart monitoring. Among them, gold nanostructures (AuNSs) have arisen as highly potential materials fabricating precise biosensors due their unique properties. present study provides update applications AuNSs detecting glucose well other biomarkers, such glycated hemoglobin (HbA1c), albumin (GA), insulin, insulin antibodies, uric acid, lactate, glutamic acid decarboxylase antibodies (GADA), focus most important factors performance sensitivity, selectivity, response time, stability. Specified values limit detection (LOD), linear concentrations, reproducibility%, recovery%, assay time were used compare studies. In conclusion, AuNSs, owing wide electrochemical window low electrical resistivity, are valuable tools design, alongside reagents and/or nanomaterials.

Language: Английский

Citations

3
Lab-on-the-Needles: A Microneedle Patch-Based Mobile Unit for Highly Sensitive Ex Vivo and In Vivo Detection of Protein Biomarkers DOI Creative Commons
Ying‐Pei Hsu, Nan‐Si Li, Hao‐Han Pang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Detection of biomarkers associated with physiological conditions provides critical insights into healthcare and disease management. However, challenges in sampling analysis complicate the detection quantification protein within epidermal layer skin viscous liquid biopsy samples. Here, we present "Lab-on-the-Needles" concept, utilizing a microneedle patch-based sensing box (MNP-based SenBox) for mobile applications. This system facilitates rapid capture directly from situ or biopsies, followed by on-needle immediate assessment. The integration horseradish peroxidase-incorporated zeolitic imidazolate framework-8 (HRP@ZIF-8) as sensitive stable signal probe, limit anti-SARS-CoV-2 NP IgA antibodies various SARS-CoV-2 S1P mutant strains improves at least 1,000-fold compared to FDA-approved commercial saliva lateral flow immune tests. Additionally, MNP-based SenBox demonstrated minimally invasive monitoring inflammatory cytokine levels (TNF-α IL-1β) rats 30 min using portable ColorReader. study highlights potential collection layers biopsies that might facilitate diagnostics longitudinal monitoring.

Language: Английский

Citations

0
Advances in Wearable Biosensors for Wound Healing and Infection Monitoring DOI Creative Commons
Dang-Khoa Vo, Kieu The Loan Trinh

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 139 - 139

Published: Feb. 23, 2025

Wound healing is a complicated biological process that important for restoring tissue integrity and function after injury. Infection, usually due to bacterial colonization, significantly complicates this by hindering the course of enhancing chances systemic complications. Recent advances in wearable biosensors have transformed wound care making real-time monitoring biomarkers such as pH, temperature, moisture, infection-related metabolites like trimethylamine uric acid. This review focuses on recent biosensor technologies designed management. Novel sensor architectures, flexible stretchable electronics, colorimetric patches, electrochemical platforms, enable non-invasive detection changes associated with wounds high specificity sensitivity. These are increasingly combined AI analytics based smartphones can timely personalized interventions. Examples PETAL patch applies multiple sensing mechanisms wide-ranging views status closed-loop systems connect therapeutic devices automate infection control. Additionally, self-powered tap into body heat or energy from biofluids themselves avoid any external batteries thus more effective field use limited resources. Internet Things connectivity allows further support remote sharing data, supporting telemedicine applications. Although developed relatively rapidly their prospects continue expand, regular clinical application stalled significant challenges regulatory, cost, patient compliance, technical problems related accuracy, biofouling, power, among others, need be addressed innovative solutions. The goal synthesize current trends, challenges, future directions monitoring, emphasis potential improve outcomes reduce healthcare burdens. innovations leading way toward next-generation bridging advanced materials science, biotechnology, digital health.

Language: Английский

Citations

0
Cryo-microneedle enabled transdermal delivery of two-dimensional Cu(Ⅱ)-TCPP nanomaterials for synergistic photodynamic-chemodynamic anti-tumor therapy DOI

Yanru An,

Yuanyuan Huo,

Zixu Wang

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113888 - 113888

Published: March 1, 2025

Language: Английский

Citations

0
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives DOI

Madhuchandra Kenchegowda,

Mohit Angolkar, Umme Hani

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Hydrogel tissue adhesive: Adhesion strategy and application DOI

Boyuan An,

Haohao Cui,

Mengke Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114755 - 114755

Published: May 1, 2025

Language: Английский

Citations

0
From mechanism to applications: Advanced microneedles for clinical medicine DOI
Yuqing Yang,

Haifu Sun,

Xiao Sun

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 51, P. 1 - 45

Published: May 5, 2025

Language: Английский

Citations

0
Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives DOI Creative Commons
Yao Li, Qiu Chen, Tingting Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, search for more effective convenient treatments has become a crucial issue in medical research. Microneedles (MNs), an innovative drug delivery system, have shown advantages treatment recent years. MNs-based which use MNs deliver drugs directly subcutaneous tissue, improve bioavailability reduce systemic side effects. This review aims summarize latest concepts, designs, types MNs, investigate materials manufacturing methods used their construction. Subsequently, mechanisms graded release research progress are further summarized. article focuses on application common diseases, with special emphasis optimization diabetic anti-obesity MNs. The main challenges future perspectives production evaluation well enhancing efficacy improving safety, elucidated.

Language: Английский

Citations

0
Microneedle Arrays for Near-Infrared-Controlled Insulin Delivery Based on Thermosensitive Microgel DOI
Yunqian Dai,

Zhenxia Ma,

Zhuo Shi

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Insulin delivery plays a crucial role in diabetic treatment. Regular painless administration methods are not ideal for insulin due to their insufficient bioavailability and inefficiency. In this study, dissolving microneedle array patches containing thermosensitive carrier P(NIPAm-AAm) microgel (MG) the photothermal agent MXene were prepared with drug-protected protocols near-infrared (NIR) light-controlled minimally invasive delivery. The microneedles (Ins-MG/MXene-HA-MNs) can penetrate stratum corneum, rapidly heat above 42 °C 10 s, promote release of an instant response NIR light exposure. vitro vivo experiments showed that Ins-MG/MXene-HA-MNs biocompatible efficient. Using one patch two brief exposures ensure effective blood levels maintain normoglycemia rats over 6 h at high glucose levels. Additionally, fabrication application drug system have been designed protect bioactivity. results MG/MXene-HA-MN realized NIR-controlled multiple on-demand dosing, highlighting its potential routine management.

Language: Английский

Citations

0