Recent Advancements of Hyaluronic Acid Nanoscaffolds in Arthritis Management DOI

Koushik Jana,

Somnath Ghosh,

Biplab Debnath

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(32)

Published: Aug. 22, 2024

Abstract Arthritis is a significant health concern affecting over 528 million people globally, reducing quality of life. The chronic nature arthritis, coupled with insufficient therapeutic effectiveness, recurrence, and adverse side effects, complicates its management. Hyaluronic acid (HA) has emerged as promising solution due to biocompatibility, non‐toxicity, targeted drug delivery capabilities, being key component the cartilage extracellular matrix widely used in managing arthritis. HA's inherent viscoelastic property ability target CD44 have spurred interest developing HA‐based systems for delivering drugs manage nanoscaffolds (HA‐NSCfs) show improved outcomes treatments, including enhanced uptake through receptor‐mediated targeting, prolonged retention synovium, reduced proinflammatory mediator expression, regeneration, toxicity sustained release, more cost‐effective treatments. This review highlights rationale using HA‐NSCfs management advanced emphasizing preclinical clinical results. It discusses various solid‐lipid nanoparticles, hydroxyapatite polyelectrolyte complexes, liposomes, bilosomes, drug‐polymer conjugates, hydrogels, inorganic polymer etc reported arthritis Additionally, identifies challenges offers suggestions address them, ultimately highlighting potential topical treatment

Language: Английский

Carbohydrate-based polymer nanocarriers for environmentally friendly applications DOI
Jagoda Chudzińska, Agata Wawrzyńczak, Agnieszka Feliczak‐Guzik

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103415 - 103415

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants DOI Open Access
Wen Chen, Qianwen Ye,

Mingshuo Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1856 - 1856

Published: Feb. 21, 2025

Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for treatment are reviewed both single-function multifunctional lubricants. Single-function mainly include glycosaminoglycans, lubricin, phospholipids, whereas composed anti-inflammatory bifunctional hydrogels, stem cell-loaded drug-loaded nanoparticles. This review emphasizes importance lubrication capacity explores structural features, properties, role these modulating intracellular inflammatory responses metabolism. Current challenges future research directions field also discussed, with aim providing scientific basis new ideas clinical OA.

Language: Английский

Citations

0
Hyaluronic Acid in Nanopharmaceuticals: An Overview DOI Creative Commons
Sina M. Matalqah, Zainab Lafi,

Sara Yousef Asha

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10444 - 10461

Published: Sept. 20, 2024

Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing

Language: Английский

Citations

3
Recent Advancements of Hyaluronic Acid Nanoscaffolds in Arthritis Management DOI

Koushik Jana,

Somnath Ghosh,

Biplab Debnath

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(32)

Published: Aug. 22, 2024

Abstract Arthritis is a significant health concern affecting over 528 million people globally, reducing quality of life. The chronic nature arthritis, coupled with insufficient therapeutic effectiveness, recurrence, and adverse side effects, complicates its management. Hyaluronic acid (HA) has emerged as promising solution due to biocompatibility, non‐toxicity, targeted drug delivery capabilities, being key component the cartilage extracellular matrix widely used in managing arthritis. HA's inherent viscoelastic property ability target CD44 have spurred interest developing HA‐based systems for delivering drugs manage nanoscaffolds (HA‐NSCfs) show improved outcomes treatments, including enhanced uptake through receptor‐mediated targeting, prolonged retention synovium, reduced proinflammatory mediator expression, regeneration, toxicity sustained release, more cost‐effective treatments. This review highlights rationale using HA‐NSCfs management advanced emphasizing preclinical clinical results. It discusses various solid‐lipid nanoparticles, hydroxyapatite polyelectrolyte complexes, liposomes, bilosomes, drug‐polymer conjugates, hydrogels, inorganic polymer etc reported arthritis Additionally, identifies challenges offers suggestions address them, ultimately highlighting potential topical treatment

Language: Английский

Citations

1