Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 111002 - 111002
Published: Nov. 1, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Language: Английский
Citations
2
Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Language: Английский
Citations
0
ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(13), P. 7572 - 7583
Published: June 21, 2024
An injectable hydrogel loading α-N-heterocyclic thiosemicarbazones with antibacterial activity was designed to attain therapy against wounds high efficiency. In the present study, FPZ-H2L synthesized by 2,6-diacetylpyridine bis(N4-methylthiosemicarbazone) (H2L) on transition-metal ions (Zn2+)-cross-linked-folic acid (FA)-co-polydopamine (PDA) (FPZ hydrogel). The (FPZ-H2L) cross-linked coordination and hydrogen bonds displayed an excellent self-healing performance completely covered irregular wound. Compared FPZ hydrogel, has stronger efficacy typical Gram-positive/negative bacteria drug-resistant bacteria. mechanisms of were related biofilm ablation, disruption cell membrane integrity, leakage nucleic acids proteins, production oxidative stress response, thus causing bacterial death. Cell Counting Kit-8 (CCK-8) test shows that compatibility, gel drug technology greatly overcomes problem cytotoxicity H2L. wound healing experiments indicated enhanced mice. These results prove mixed broadened field vision for design dressings.
Language: Английский
Citations
3
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)
Published: Dec. 1, 2024
ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.
Language: Английский
Citations
3
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110133 - 110133
Published: June 1, 2024
Language: Английский
Citations
1
Materials Horizons, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Chlorhexidine (CHX) is considered the gold standard for controlling periodontal plaque and has been extensively used as a topical agent in treating periodontitis. Nevertheless, practical clinical application of CHX still constrained by inherent limitations its properties, including toxicity, inadequate biofilm scavenging capacity, single biological effect. In this study, polyphenolic epigallocatechin gallate (EGCG) employed to integrate with form an EGCG-CHX nanoplatform
Language: Английский
Citations
0
APL Materials, Journal Year: 2024, Volume and Issue: 12(11)
Published: Nov. 1, 2024
Recently, there has been growing interest in plant-inspired materials for various biological, medical, and industrial applications. Notably, tannic acid-based exhibit remarkable adhesive properties can be used a variety of applications, particularly biomedical In addition, mixtures composed acid polymers (e.g., polyvinyl alcohol) excellent adhesion to substrates. this study, we developed gallol-containing chitosan (G-CS), alcohol (PVA), (TA) composite (G-CPT) hydrogels as wood materials. G-CPT were immediately formed by mixing the G-CS/PVA solution with TA solution. Rheological analysis revealed an increase elastic modulus (G′) addition small amounts G-CS. detachment stress sticks attached using was 142.2 ± 7.2 MPa, which substantially higher than that G-CS (5.3 1.4 kPa), PVA (2.2 0.2 (0.4 0.1 PVA/TA (106.5 2.5 MPa). Furthermore, adhesives scion grafting into rootstock English ivy. These findings highlight importance eco-friendly enormous potential agricultural
Language: Английский
Citations
0
Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 111002 - 111002
Published: Nov. 1, 2024
Language: Английский
Citations
0