Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass-Based Polymeric Additive DOI Creative Commons

Susanne Hammer,

Filippo Nanto, Paolo Canu

et al.

Published: July 28, 2023

The utilization of water as a sustainable reaction medium has important advantages over traditional organic solvents. Hydroxypropyl methylcellulose emerged biomass-based polymeric additive that enables reactions in through hydrophobic effects. However, such conditions imply slurries mixtures, where the efficacy mass transfer and mixing decreases with increasing vessel size. In order to circumvent this limitation establish an effectively scalable platform for performing hydroxypropyl methylcellulose-mediated aqueous transformations, we utilized oscillatory plug flow reactors feature smart dimensioning design principle across different scales. Using nucleophilic aromatic substitutions valuable model reactions, rapid parameter optimization was performed first small-scale instrument having internal channel volume 5 mL. optimal were then directly transferred 15 mL reactor, achieving three-fold scale-up without re-optimizing any parameters. By precisely fine-tuning oscillation parameters, system achieved homogeneous suspension solids, preventing settling particles clogging process channels. Ultimately, resulted robust multiphasic under conditions.

Language: Английский

Aqueous Micelles as Solvent, Ligand, and Reaction Promoter in Catalysis DOI Creative Commons

Jagdeep K. Virdi,

Ashish Dusunge,

Sachin Handa

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(2), P. 301 - 317

Published: Jan. 16, 2024

Water is considered to be the most sustainable and safest solvent. Micellar catalysis a significant contributor chemistry in water. It promotes pathways involving water-sensitive intermediates transient catalytic species under micelles' shielding effect while also replacing costly ligands dipolar-aprotic solvents. However, there lack of critical information about micellar catalysis. This includes why it works better than traditional organic solvents, specific rules differ from those conventional catalysis, how limitations can addressed future. Perspective aims highlight current gaps our understanding provide an analysis designer surfactants' origin essential components. will fundamental including aqueous micelles simultaneously perform multiple functions such as solvent, ligand, reaction promoter.

Language: Английский

Citations

29
N,N‐Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development DOI Creative Commons
James Sherwood, Fernando Alberício, Beatriz G. de la Torre

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: 17(8)

Published: Jan. 10, 2024

Abstract As of December 2023, the use common solvent N , ‐dimethyl formamide (DMF) will be restricted in European Union because its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain restrictions on DMF, which disciplines affected, how substitute DMF keep research development commercially relevant.

Language: Английский

Citations

26
Towards a sustainable tomorrow: advancing green practices in organic chemistry DOI
Sudripet Sharma, Fabrice Gallou, Sachin Handa

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(11), P. 6289 - 6317

Published: Jan. 1, 2024

Chemistry in water, leveraging its solvent properties, provides a safer and more sustainable alternative to traditional organic methods.

Language: Английский

Citations

23
Recent Highlights in Micellar Catalysis: An Industrial Outlook DOI
Tharique N. Ansari, Guolin Xu, Andrew Z. Preston

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(4), P. 816 - 830

Published: March 14, 2024

From the context of sustainability, contemporary synthetic organic chemistry practices require significant transformation, as indicated by various sustainability matrices like atom economy, process mass intensity (PMI), E-factor, and DOZN. These factors have evidently unveiled inherent inefficiencies intrinsic to conventional protocols identified solvents principal causative agent. In response, utilization water a primary reaction medium for transformations has emerged an appealing alternative. This approach flourished with emergence micellar catalysis, where amphiphilic molecules alter bulk aqueous medium's solvation properties promote desired chemical transformation under milder sustainable conditions. After 2010, this technology gained considerable momentum established foundational framework performing reactions conditions, consequently mitigating dependency on hazardous solvents. perspective, recent advances in field catalysis will be discussed industrial applications, along future directions challenges associated regime.

Language: Английский

Citations

11
Is Micellar Catalysis Green Chemistry? DOI Creative Commons
Fabrizio Fabris, Markus Illner, Jens‐Uwe Repke

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4809 - 4809

Published: June 16, 2023

Many years ago, twelve principles were defined for carrying out chemical reactions and processes from a green chemistry perspective. It is everyone’s endeavor to take these points into account as far possible when developing new or improving existing ones. Especially in the field of organic synthesis, area research has thus been established: micellar catalysis. This review article addresses question whether catalysis by applying reaction media. The shows that many can be transferred an solvent medium, but surfactant also crucial role solubilizer. Thus, carried much more environmentally friendly manner with less risk. Moreover, surfactants are being reformulated their design, degradation add extra advantages match all chemistry.

Language: Английский

Citations

23
Aminations of Aryl Halides Using Nitroaromatics as Coupling Partners: Overcoming the Hydrodehalogenation Pathway under a Hydrogen Atmosphere in Water DOI
Tharique N. Ansari, Ramesh Hiralal Choudhary, Maarten Nachtegaal

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(6), P. 4099 - 4107

Published: March 1, 2024

While overcoming hydrodehalogenation in a reductive environment, catalytic aqueous micellar technology has been developed for the C–N cross-coupling of nitroarenes with aryl halides. The bimetallic palladium–copper (Pd–Cu) nanocatalyst configuration micelles selectively facilitates highly selective amination pathway, possibly through situ formation Cu-hydride species as supported by nuclear magnetic resonance (NMR) spectroscopy. These prevent Pd-hydride-mediated even under molecular hydrogen atmosphere. thoroughly characterized using various spectroscopic and imaging tools, including 31P 1H NMR, X-ray absorption spectroscopy (XAS), high-resolution transmission electron microscopy. oxidation states Cu Pd needed desired selectivity have verified photoelectron spectroscopy, while metal–metal metal–ligand interactions XAS. Control experiments performed to determine significance each constituent on reaction pathway. As revealed control mass spectrometry, pathway does not involve azo- or nitroso-type intermediates. methodology can be applied numerous substrates broad functional protecting group tolerance.

Language: Английский

Citations

6
A Metallomicellar Catalyst for Controlled Oxidation of Alcohols and Lignin Mimics in Water using Open Air as Oxidant DOI
Prabaharan Thiruvengetam,

Pragyansmruti Sunani,

Dillip Kumar Chand

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: 17(10)

Published: Jan. 15, 2024

Abstract Alcohol groups and β ‐O‐4 (C−C) linkages are widespread in biomass feedstock that abundant renewable resource for value‐added chemicals. The development of sustainable protocols direct oxidation or oxidative cleavage materials a controlled fashion, using open air as an oxidant is intellectually stimulating task to produce industrially important carbonyls. Further, the depolymerization lignin into fine chemicals has evoked interest recent times. Herein, we report first example catalyst system could activate molecular oxygen from atmospheric cleavage/depolymerization such alcohols, real water under conditions. selectivity carbonyl products by altering pH between ~7.0 ~12.0. current strategy highlights non‐involvement any external co‐catalyst, oxidant, radical additives, and/or destructive organic solvents. shows wide substrate scope eminent functional group tolerance. upscaled multigram synthesis inexpensive easily available evidences practical utility developed protocol. A plausible mechanism been proposed with help few experiments, kinetic computational studies.

Language: Английский

Citations

3
Green synthesis of High-Yield red fluorescent carbon dots from Amaranth for sensitive water detection in organic solvents DOI

Linping Ma,

Shihua Liao,

Jiawen Liu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112654 - 112654

Published: Jan. 1, 2025

Language: Английский

Citations

0
Solvent-free green preparation of reinforced FEP/SiO2-SSM composite membrane for high temperature waste oil treatment DOI
Shuang Zhang, Kaikai Chen, Haibo Yan

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 70, P. 106978 - 106978

Published: Jan. 14, 2025

Language: Английский

Citations

0
Micelle-Enabled In Situ Surface Modification of Porous Organic Polymers: Formation of Heterogeneous Microcolony for Efficient Suzuki–Miyaura Coupling in Water DOI

Rajan Yadav,

Pritesh Keshari,

Susanta Hazra

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Synthesis of water-stable and dispersible heterogeneous catalysts having high catalytic efficiency is more challenging compared with homogeneous due to their low dispersity, activity, spatial confinement active centers in bulk water. Herein, we are describing systematic studies for the development microconfinement participation aqueous micelles via temporal surface modification porous organic polymer derived from phosphine ligands. Detailed investigations using various techniques such as transmission electron microscopy (TEM), scanning (SEM), tensiometry, confocal laser (CLSM), fluorescence lifetime imaging (FLIM) have been used understand role micelles, reagents, materials generation microcolonies Two-color crossover experiments also performed exchange reagents or vice versa, materials. The surfactant-modified ligation stabilization palladium, which was evidenced by high-resolution (HR-TEM), high-angle annular dark-field (HAADF-STEM), X-ray photoelectron spectroscopy (XPS) analysis. act confined space catalysis water showcasing Suzuki-Miyaura cross-coupling reaction a ppm level Pd loading under mild conditions. catalyst found be recyclable five cycles; easy scale-up C-C couplings additional features. Moreover, these data provide an opportunity revising models micellar systems that underpin sustainable

Language: Английский

Citations

0