The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(22), P. 16473 - 16484
Published: Nov. 7, 2024
We
have
developed
an
ultrasound-assisted
remote
benzylic
C(sp3)–H
alkylation
of
N-fluorobenzamides
with
enol
silanes;
a
series
β-aryl
substituted
propiophenones
was
generated
in
good
to
high
yields.
This
reaction
represents
formal
C(sp3)–C(sp3)
coupling
and
features
simplicity,
efficiency,
wide
substrate
scope
multiple-step
sequential
process,
which
involves
N–F
homolysis,
1,5-hydrogen
atom
transfer,
radical
addition,
oxidation
by
copper(II)
salt,
removal
the
trimethylsilyl
group.
Also,
DFT
theoretical
calculations
Marcus
theory
were
employed
consolidate
proposed
mechanism.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(21), P. 8459 - 8493
Published: Jan. 1, 2023
This
review
comprehensively
summarizes
visible
light-induced
difunctionalization
strategies
for
alkene
and
alkyne
systems
in
metal-free
conditions
with
literature
coverage
up
to
July
2023.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2186 - 2208
Published: April 4, 2024
Abstract
This
review
presents
an
outline
of
current
advancements
in
the
photochemical
and
electrochemical
synthesis
oxazoles
isoxazoles.
Oxazole
isoxazole
are
important
building
blocks
for
a
variety
medicinally
useful
compounds.
Therefore,
these
heterocycles
via
sustainable
technologies
is
worth
demanding.
Photochemical
two
among
few
technologies.
covers
brief
discussion
on
reaction
parameters
like
catalysts,
substrates
scope,
temperature,
solvents,
electrodes,
electrolytes
(in
case
process),
light
source
process)
individual
reaction.
Detailed
mechanistic
insight
each
also
presented.
Finally,
summary,
future
direction
toward
development
effective
methods
isoxazoles
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8721 - 8733
Published: June 4, 2024
A
novel
strategy
for
the
difunctionalization
of
electron-deficient
alkenes
with
aryl
sulfonium
salts
to
access
remote
sulfur-containing
oxindole
derivatives
by
using
in
situ-formed
copper(I)-based
complexes
as
a
photoredox
catalyst
is
presented.
This
method
enables
generation
C(sp3)-centered
radicals
through
site
selective
cleavage
C–S
bond
under
mild
conditions.
Moreover,
oxidation
reactions
desired
products
provide
new
preparation
sulfoxide
or
sulfone-containing
compounds.
Importantly,
this
approach
can
be
easily
applied
late-stage
modification
pharmaceuticals
molecules.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11370 - 11376
Published: Jan. 1, 2025
Herein,
we
have
developed
an
organophotocatalytic
trifluoromethylation
of
6-azauracils
using
inexpensive
Langlois
reagent
to
prepare
a
variety
trifluoromethylated
azauracil
derivatives
under
ambient
air
condition.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(31), P. 21271 - 21279
Published: July 23, 2024
1,2-Difunctionalization
of
styrenes,
adding
two
distinct
functional
groups
across
the
C═C
double
bond,
has
emerged
as
a
powerful
tool
for
enhancing
molecular
complexity.
Herein,
we
report
development
regioconvergent
β-acyloxylation-α-ketonylation
styrenes
through
bromo/acyloxy
transposition
(BrAcT)
and
excited-state
copper
catalysis.
This
approach
is
amenable
to
gram-scale
synthesis
tolerates
wide
range
complex
frameworks,
including
derivatives
natural
products
marketed
drugs.
Our
experimental
computational
studies
suggest
unique
mechanism
featuring
dynamic,
ionic
BrAcT
process
copper-catalyzed
redox
reactions.
We
anticipate
that
this
could
serve
broadly
applicable
versatile
strategy
β-acyloxylation-α-functionalization
creating
valuable
intermediates
preparing
new
pharmaceuticals,
agrochemicals,
materials.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(75), P. 10402 - 10405
Published: Jan. 1, 2024
A
new
visible-light-mediated
non-directed
oxidative
annulation
between
2-arylindazoles
and
electron-deficient
olefins
using
commercially
available
piperidine-1-sulfonyl
chloride
as
the
radical
precursor
to
afford
fused
5,6-dihydroindazolo[2,3-
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(18), P. 4573 - 4580
Published: Jan. 1, 2023
A
sustainable
photoredox-mediated
protocol
for
the
construction
of
unsymmetrical
diarylamines
using
a
Cu/Ru
catalytic
system
has
been
successfully
devised
with
wide
substrate
scope
and
good
yields.
