Green Synthesis of Quinazolinones via Selective Electro‐oxidation Using Iron Electrode and NaCl Electrolyte as an Eco‐friendly Electrolyte DOI
Ali Basem, Ahmed M. Naglah, Zaman Abdalhussein Ibadi Alaridhee

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 13, 2024

Abstract Primary alcohols 2(a–h) and o‐aminobenzamides 1(a–h) can be selectively oxidized electrochemically to yield dihydroquinazolinone 4(a–h) quinazolinones 5(a–h) in an efficient chemoselective manner. This methodology employs sodium chloride (NaCl) 3(a) as a co‐catalyst electricity the oxidizing agent, utilizing cost‐effective commercially available materials such Graphite anode, Iron (Fe) cathode, isopropyl alcohol (iPrOH) solvent weak base. The synthesis yields various quinazolinone derivatives with diverse structural characteristics good quantities, showcasing method‘s broad applicability. approach facilitates production of range dihydroquinazolinones (24 examples), highlighting its versatility compatibility different functional groups. Characterization synthesized included CHN analysis, 1 HNMR spectroscopy, determination melting points.

Language: Английский

Green Synthesis of Quinazolinones via Selective Electro‐oxidation Using Iron Electrode and NaCl Electrolyte as an Eco‐friendly Electrolyte DOI
Ali Basem, Ahmed M. Naglah, Zaman Abdalhussein Ibadi Alaridhee

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 13, 2024

Abstract Primary alcohols 2(a–h) and o‐aminobenzamides 1(a–h) can be selectively oxidized electrochemically to yield dihydroquinazolinone 4(a–h) quinazolinones 5(a–h) in an efficient chemoselective manner. This methodology employs sodium chloride (NaCl) 3(a) as a co‐catalyst electricity the oxidizing agent, utilizing cost‐effective commercially available materials such Graphite anode, Iron (Fe) cathode, isopropyl alcohol (iPrOH) solvent weak base. The synthesis yields various quinazolinone derivatives with diverse structural characteristics good quantities, showcasing method‘s broad applicability. approach facilitates production of range dihydroquinazolinones (24 examples), highlighting its versatility compatibility different functional groups. Characterization synthesized included CHN analysis, 1 HNMR spectroscopy, determination melting points.

Language: Английский

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