Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(21), P. 4202 - 4211
Published: Jan. 1, 2024
Pillararenes
have
gained
great
interest
among
researchers
in
many
fields
due
to
their
symmetric
structure
and
facile
functionalization.
In
this
review,
we
summarize
recent
progress
for
pillararenes
as
antimicrobial
agents,
ranging
from
cationic
peptide-modified
sugar-functionalized
pillararenes.
Moreover,
structure-activity
relationships
are
presented,
mechanisms
of
action
discussed.
As
a
state-of-the-art
technology,
opportunities
outlook
also
outlined
emerging
field.
Overall,
potent
inhibitory
activity
high
biocompatibility
give
them
potential
the
development
novel
agents.
This
research
focuses
on
integrating
supramolecular
chemistry
and
reverse
saturable
absorption
(RSA)
principles,
focusing
combining
pillar[5]arene
frameworks
with
metal-complexed
ligands.
By
delving
into
these
systems'
theoretical
underpinnings
potential
applications,
we
shed
light
the
synergistic
effects
that
may
arise
from
this
innovative
approach.
We
envision
promising
advancements
in
photonic
electronic
materials
by
unique
structural
properties
of
pillar[5]arenes
RSA
Although
specific
proprietary
details
are
not
discussed,
work
pave
way
for
further
exploration
exciting
interdisciplinary
field.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(16), P. 3828 - 3828
Published: Aug. 12, 2024
Efficient
delivery
of
therapeutic
agents
to
the
lesion
site
or
specific
cells
is
an
important
way
achieve
“toxicity
reduction
and
efficacy
enhancement”.
Macrocycles
have
always
provided
many
novel
ideas
for
drug
gene
loading
processes.
Specifically,
macrocycles
represented
by
crown
ethers,
cyclodextrins,
cucurbit[n]urils,
calix[n]arenes,
pillar[n]arenes
unique
properties,
which
are
different
cavity
structures,
good
biocompatibility,
stability.
Benefited
from
these
diverse
a
variety
supramolecular
systems
can
be
designed
constructed
effectively
improve
physical
chemical
properties
guest
molecules
as
needed.
This
review
provides
outlook
on
current
application
status
main
limitations
in
systems.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(48), P. 35697 - 35703
Published: Jan. 1, 2024
Two
categories
of
supramolecular
polymer
monomers
were
produced
by
introducing
the
ureidopyrimidone
quadruple-hydrogen
bonding
assemblies
on
calix[4]arene
and
β-cyclodextrin
host
units.
The
adsorption
capacity
these
polymers
for
different
metal
ions
was
investigated
static
adsorption.
results
showed
that
at
pH
=
6
when
equilibrium
reached,
with
calixarene
as
main
body
adsorbed
up
to
99%
Pb
Supramolecular chemistry,
Journal Year:
2023,
Volume and Issue:
34(5-6), P. 239 - 246
Published: June 1, 2023
Nano-drug
delivery
systems
have
been
widely
used
in
antitumor
therapy
due
to
their
good
biocompatibility
and
low
toxicity.
However,
improving
drug-carrying
properties
drug
release
from
carriers
remains
a
challenge.
In
this
study,
we
successfully
constructed
pH-responsive
supramolecular
spherical
nanoparticles
by
self-assembling
D-alanine-modified
water-soluble
cationic
pillar[5]arene
(DAP5)
sodium
laurate
(SL)
form
complexes
aqueous
solution.
The
results
demonstrated
that
DAP5
loaded
with
doxorubicin
hydrochloride
(DOX
HCl)
exhibited
an
encapsulation
rate
of
60.0%
loading
capacity
10.5%.
These
continuously
released
the
weakly
acidic
environment
simulates
tumour
cells.
Furthermore,
SL⊂DAP5
human
normal
liver
cells
(L-02)
(IC50
>10
μmol/L),
while
DOX⊂SL⊂DAP5
stronger
cytotoxicity
against
four
(Hela,
HepG2,
MGC-803,
T-24)
compared
free
DOX.
Notably,
showed
IC50
only
1.04
μM
for
HepG2
cells,
which
was
approximately
30.32%
DOX
(3.43
μM)
after
24
hours
incubation.
findings
provide
valuable
insights
future
development
systems,
aiming
enhance
utilisation
reduce
toxic
side
effects
treatment.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(11), P. 3019 - 3025
Published: Jan. 1, 2024
A
multicationic
pillar[5]arene
noncovalently
crosslinks
hyaluronic
acid
to
afford
ionic
supramolecular
polymers
for
intramolecular
delivery
of
short
DNA.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(21), P. 4202 - 4211
Published: Jan. 1, 2024
Pillararenes
have
gained
great
interest
among
researchers
in
many
fields
due
to
their
symmetric
structure
and
facile
functionalization.
In
this
review,
we
summarize
recent
progress
for
pillararenes
as
antimicrobial
agents,
ranging
from
cationic
peptide-modified
sugar-functionalized
pillararenes.
Moreover,
structure-activity
relationships
are
presented,
mechanisms
of
action
discussed.
As
a
state-of-the-art
technology,
opportunities
outlook
also
outlined
emerging
field.
Overall,
potent
inhibitory
activity
high
biocompatibility
give
them
potential
the
development
novel
agents.
