Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications DOI
Yajun Shuai, Meidan Zheng, Subhas C. Kundu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 15, 2024

3D in vitro model has emerged as a valuable tool for studying tissue development, drug screening, and disease modeling. systems can accurately replicate microstructures physiological features, mirroring the vivo microenvironment departing from conventional 2D cell cultures. Various models utilizing biomacromolecules like collagen synthetic polymers have been developed to meet diverse research needs address complex challenges of contemporary research. Silk proteins, bearing structural functional similarities collagen, increasingly employed construct advanced systems, surpassing limitations This review examines silk proteins' composition, structure, properties, functions, elucidating their role models. Furthermore, recent advances biomedical applications involving silk-based organoid are discussed. In particular, unique attributes matrix constituents constructs highlighted, providing meticulous evaluation importance. Additionally, it outlines current hurdles complexities while contemplating future avenues, thereby paving way developing biomimetic protein-based microtissues.

Language: Английский

Synthesis and Properties of Injectable Hydrogel for Tissue Filling DOI Creative Commons
Chunyu Xie,

Ga Liu,

Lingshuang Wang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 430 - 430

Published: March 21, 2024

Hydrogels with injectability have emerged as the focal point in tissue filling, owing to their unique properties, such minimal adverse effects, faster recovery, good results, and negligible disruption daily activities. These hydrogels could attain through chemical covalent crosslinking, physical or biological crosslinking. reactions allow for formation of reversible bonds delayed gelatinization, ensuring a minimally invasive approach filling. Injectable facilitate augmentation regeneration by offering slow degradation, mechanical support, modulation functions host cells. This review summarizes recent advancements synthetic strategies injectable introduces application Ultimately, we discuss prospects prevailing challenges developing optimal augmentation, aiming chart course future investigations.

Language: Английский

Citations

13
Bioengineered Silk Protein‐Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications DOI
Yajun Shuai, Meidan Zheng, Subhas C. Kundu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 15, 2024

3D in vitro model has emerged as a valuable tool for studying tissue development, drug screening, and disease modeling. systems can accurately replicate microstructures physiological features, mirroring the vivo microenvironment departing from conventional 2D cell cultures. Various models utilizing biomacromolecules like collagen synthetic polymers have been developed to meet diverse research needs address complex challenges of contemporary research. Silk proteins, bearing structural functional similarities collagen, increasingly employed construct advanced systems, surpassing limitations This review examines silk proteins' composition, structure, properties, functions, elucidating their role models. Furthermore, recent advances biomedical applications involving silk-based organoid are discussed. In particular, unique attributes matrix constituents constructs highlighted, providing meticulous evaluation importance. Additionally, it outlines current hurdles complexities while contemplating future avenues, thereby paving way developing biomimetic protein-based microtissues.

Language: Английский

Citations

8