Stable CAAC‐triazenes: A New Nitrogen Ligand System with Donor and Conformational Flexibility, and with Application in Olefin Activation Catalysis

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(38)

Published: April 30, 2024

N-heterocyclic imines such as pyridylidene amines impart high catalytic activity when coordinated to a transition metal, largely imposed by their electronic flexibility. Here, this donor flexibility has been applied for the first time CAAC-based systems through synthesis of CAAC-triazenes. These new ligands offer larger π-conjugation that extends from carbene three nitrogens rather than just one, observed in imines. We demonstrate straightforward CAAC-triazenes containing different substituents on terminal triazene nitrogen. compounds are remarkably stable up 120 °C without loss N

Language: Английский

Functionalization of Siloxanes with Arynes Generated from <i>o</i>-Triazenylarylboronic Acids

Chemical and Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 72(5), P. 487 - 497

Published: May 20, 2024

Herein, we report the functionalization of polyhedral oligosilsesquioxanes (POSS) and related siloxanes with arynes. Using o-triazenylarylboronic acids as aryne precursors silica gel activator, transformation siloxane bearing various arynophilic moieties on side chains was achieved high yields without touching core. This method applied to conjugation POSS pharmaceutical cores using an derived from synthetic intermediate cabozantinib. Furthermore, orthogonal dual realized by combining reaction Huisgen cyclization.

Language: Английский