Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Abstract
Starting
from
N
‐acyl
sulfonimidamides,
mechanochemically
generated
rhodium
nitrenoids
undergo
intramolecular
N−O
couplings
to
provide
unprecedented
1,3,2,4‐oxathiadiazole
3‐oxides
in
good
excellent
yields.
The
cyclization
proceeds
efficiently
with
a
catalyst
loading
of
only
0.5
mol
%
the
presence
phenyliodine(III)
diacetate
(PIDA)
as
oxidant.
Neither
an
inert
atmosphere
nor
additional
heating
is
required
this
solvent‐free
procedure.
Under
heat
or
blue
light,
newly
formed
five‐membered
heterocycles
function
nitrene
precursors
reacting
sulfoxides
exemplified
by
imidation
dimethyl
sulfoxide.
ChemCatChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Piezoelectric
materials
offer
great
promise
due
to
their
ability
generate
electric
fields
under
mechanical
stress,
producing
surface
charges
that
drive
otherwise
kinetically
sluggish
redox
reactions.
The
strained
surfaces
of
these
provide
a
unique
advantage
in
controlling
product
selectivity
and
enabling
reaction
pathways
are
unattainable
with
conventional
methods.
This
perspective
highlights
advancements,
challenges,
the
future
potential
piezoelectric
synthetic
organic
chemistry,
focus
on
designing
optimized
for
piezocatalyzed
synthesis.
Piezocatalysis
is
industrially
relevant
because
its
operational
simplicity,
mild,
gram
scale
synthesis
reusable
catalysts,
minimal
solvent
use,
air
tolerant
conditions.
It
involves
cycles
facilitate
one
electron
events
without
requiring
light
exposure
or
electrical
bias.
Despite
significant
progress,
many
fundamental
aspects
yet
be
fully
understood.
One
example
correlation
between
piezoelectricity
catalytic
activity,
which
not
always
linear,
as
demonstrated
by
comparison
tetragonal
cubic
BaTiO₃.
While
BaTiO₃
piezoelectric,
it
shows
excellent
activity
certain
reactions
such
arylation,
dicarbonylation,
cyclization
mechanochemical
conditions
comparable
Considering
all
aspects,
this
aims
stimulate
discussion
advance
promising
field
right
direction.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(77), P. 10629 - 10641
Published: Jan. 1, 2024
Large
or
repeated
mechanical
loads
degrade
polymeric
materials
by
accelerating
chain
fragmentation.
This
mechanochemical
backbone
fracture
usually
occurs
homolysis
of
otherwise
inert
C-C,
C-O
and
C-S
bonds,
generating
highly
reactive
macroradicals.
Because
is
detrimental
on
its
own
the
resulting
macroradicals
can
initiate
damaging
reaction
cascades,
a
major
thrust
in
contemporary
polymer
mechanochemistry
to
suppress
it,
release
"hidden
length"
that
dissipates
local
molecular
strain.
Here
we
summarize
an
emerging
complementary
strategy
channelling
mechanochemically
generated
cascades
form
new
load-bearing
chemical
which
enables
self-healing
self-strengthening,
and/or
generate
mechanofluorescence,
could
yield
detailed
quantitative
understanding
how
material-failure-inducing
macroscopic
distribute
across
network.
We
aim
identify
generalizable
lessons
derivable
from
reported
implementations
this
outline
key
challenges
adapting
it
diverse
loading
scenarios.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Abstract
Starting
from
N
‐acyl
sulfonimidamides,
mechanochemically
generated
rhodium
nitrenoids
undergo
intramolecular
N−O
couplings
to
provide
unprecedented
1,3,2,4‐oxathiadiazole
3‐oxides
in
good
excellent
yields.
The
cyclization
proceeds
efficiently
with
a
catalyst
loading
of
only
0.5
mol
%
the
presence
phenyliodine(III)
diacetate
(PIDA)
as
oxidant.
Neither
an
inert
atmosphere
nor
additional
heating
is
required
this
solvent‐free
procedure.
Under
heat
or
blue
light,
newly
formed
five‐membered
heterocycles
function
nitrene
precursors
reacting
sulfoxides
exemplified
by
imidation
dimethyl
sulfoxide.
ChemPlusChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 31, 2024
Abstract
Mechanochemical
reactions
by
ball
milling
have
opened
new
avenues
in
chemical
synthesis.
Particularly,
mechanochemistry
has
facilitated
the
reaction
of
insoluble
materials
to
simplify
stablished
synthetic
protocols
and
develop
ones.
One
notable
application
involves
use
calcium
carbide
(CaC
2
)
as
a
C
‐synthon
through
mechanochemistry,
which
offered
more
practical
alternative
incorporate
‐units
compared
conventional
highly
flammable
gaseous
acetylene.
For
example,
milling,
acetylenic
anions
[C
]
2−
found
CaC
been
harnessed
for
synthesis
diverse
functional
carbon
well
discrete
organic
molecules.
This
Concept
aims
contribute
conceptualization
this
innovative
approach
while
highlighting
both
its
advantages
challenges
inherent
.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
Abstract
Organic
synthesis
has
historically
relied
on
solution‐phase,
polar
transformations
to
forge
new
bonds.
However,
this
paradigm
is
evolving,
propelled
by
the
rapid
evolution
of
radical
chemistry.
Additionally,
organic
witnessing
a
simultaneous
resurgence
in
mechanochemistry,
formation
bonds
solid‐state,
further
contributing
shift
status
quo.
The
aforementioned
advances
chemistry
have
predominantly
occurred
solution
phase,
while
majority
mechanochemical
feature
transformations.
Herein,
we
discuss
rapidly
advancing
area
synthesis:
reactions.
Solid‐state
reactions
offer
improved
green
metrics,
better
reaction
outcomes,
and
access
intermediates
products
that
are
difficult
or
impossible
reach
solution.
This
review
explores
these
context
small
molecule
synthesis,
from
early
findings
current
state‐of‐the‐art,
underscoring
pivotal
role
solid‐state
likely
play
sustainable
chemical
synthesis.
Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
63(32), P. 15247 - 15258
Published: July 29, 2024
Group
1
metal
molecular
chemistry
is
dominated
by
a
+1
oxidation
state,
while
0
state
widespread
in
the
metals.
A
more
exotic,
yet
still
available,
of
group
-1,
i.e.,
alkalide.
Reported
as
early
1970s,
alkalides
appear
every
modern
inorganic
textbook
an
iconic
chemical
curiosity,
their
reactivity
remains
unexplored.
This
due
to
synthetic
hurdles.
In
this
work,
we
report
first
facile
synthesis
archetypical
alkalide
complex,
[Na
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(37), P. 13774 - 13782
Published: Sept. 3, 2024
(S)-aromatic
epoxides
are
of
great
importance
in
the
production
pharmaceuticals
and
biologically
active
natural
products.
Consequently,
developing
efficient,
ecofriendly,
economical
methods
for
continues
to
be
tremendous
interest
organic
synthesis.
Herein,
we
report
a
novel
protocol
efficient
synthesis
by
coupling
mechanochemical
biocatalysis
from
commercially
available
cheap
materials.
The
first
step
process
is
halogenation
aromatic
ketones
with
N-halosuccinimides
(NXS)
under
ball-milling
conditions
form
α-haloaromatic
ketones.
This
followed
one-pot
asymmetric
bioreduction–cyclization
sequence
affording
various
good
yields,
which
pure
enough
without
further
purification.
Compared
traditional
chemical
approaches,
this
mechano-biocatalytic
has
prominent
advantages,
including
inexpensive
starting
materials,
short
reaction
time,
simplicity
operation,
environmental
benignity,
broad
substrate
spectrum,
excellent
enantioselectivities,
easy
isolation
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(50), P. 48870 - 48883
Published: Dec. 6, 2024
The
design
of
environmentally
friendly
methods
for
synthesizing
molecular
receptors
is
an
expanding
area
within
applied
organic
chemistry.
This
work
systematically
summarizes
advances
in
the
mechanochemical
synthesis
chemoreceptors.
It
discusses
key
achievements
related
to
chemoreceptors
containing
azine,
Schiff
base,
thiosemicarbazone,
hydrazone,
rhodamine
6G,
imide,
or
amide
moieties.
Additionally,
it
highlights
application
potential
mechanochemically
synthesized
recognition
ions
and
small
molecules,
along
with
a
discussion
mechanisms
detection
processes.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Abstract
A
mechanochemical,
highly
regioselective
rhodium(III)‐catalyzed
C─H
methylation
of
8‐methylquinolines
is
reported.
The
method
reported
in
this
study,
often
solvent‐free
or
uses
minimal
solvent
(liquid
assisted
grinding),
operates
without
external
heating
under
mild
reaction
conditions,
demonstrating
tolerance
for
various
functional
groups.
Moreover,
the
time
significantly
reduced
compared
to
solvent‐based
variant.
Notably,
can
be
carried
out
using
a
pestle
and
mortar
instead
ball
milling
as
well,
highlighting
operational
simplicity
approach
achieving
challenging
C(sp
3
)‐H
activation
more
sustainable
conditions.
