One-pot Multicomponent Tandem Reaction for the Rapid Synthesis of 2-Amino-3-benzylindoles
Pengyan Zhang,
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Chenrui Liu,
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Maoyi Dai
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et al.
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
novel
one-pot
oxidative
cross-dehydrogenation
coupling
(CDC)
reaction
has
been
developed
for
the
selective
construction
of
C–N
and
C–C
bonds
at
C2,3-positions
indoles.
Language: Английский
Organoselenium-Catalyzed C2,3-Diarylation of N–H Indoles
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(10), P. 7216 - 7224
Published: May 2, 2024
An
organoselenium-catalyzed
C2,3-diarylation
of
unprotected
N–H
indoles
with
electron-rich
aromatics
has
been
developed.
This
one-pot
multicomponent
tandem
cross-dehydrogenation
coupling
reaction
allows
for
the
incorporation
two
different
aromatic
groups
to
indoles.
More
importantly,
this
approach
offers
significant
advantages,
including
a
high
atom
and
step
economy,
eliminating
need
prepreparation
substrates,
streamlining
synthetic
process
enhancing
its
practicality.
Overall,
presents
an
efficient
versatile
strategy
functionalization
indole
derivatives.
Language: Английский
Solvent-controlled switchable multicomponent tandem oxidative triple functionalization of indolines
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(7), P. 1933 - 1940
Published: Jan. 1, 2024
A
new
one-pot
method
for
solvent-controlled
switchable
tandem
oxidative
triple
functionalization
of
indolines
has
been
developed
via
successive
regioselective
chalcogenation,
oxidation,
amination
and
halogenation.
Language: Английский
Iron-Catalyzed Friedel–Crafts-type 3,5-Diacylation of Indoles
Xiaoting Gu,
No information about this author
Maoyi Dai,
No information about this author
Xirui Qing
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et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(14), P. 10272 - 10282
Published: July 5, 2024
The
exploration
of
remote
functionalization
indoles
is
impeded
by
the
inherently
dominant
reactivity
intrinsic
to
pyrrole
moiety.
Herein,
we
delineate
a
novel
strategy
facilitated
Lewis
acid
mediation,
enabling
C-H
functionalization,
which
culminates
in
synthesis
an
array
selectively
functionalized
indole
derivatives,
encompassing
3-trifluoroacetyl
and
5-benzoyl
motifs,
utilizing
trifluoroacetic
anhydride
various
acyl
chlorides.
Notably,
protocol
exhibits
versatility,
as
epitomized
extension
C5-acylation
alkylation
sulfonation
reactions.
This
methodology
distinguished
its
exemplary
regio-
chemo-selectivity,
extensive
substrate
scope,
commendable
tolerance
diverse
functional
groups,
employment
comparatively
mild
reaction
conditions.
Language: Английский
Iron-Catalyzed C–H Arylphosphorylation of Quinoxalines
Maoyi Dai,
No information about this author
Meilan Xu,
No information about this author
Xiaoting Gu
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7672 - 7677
Published: Sept. 4, 2024
A
one-pot
strategy
for
iron-catalyzed
C2,3-H
arylphosphorylation
of
electron-deficient
quinoxalines
with
phosphines
and
aryl
compounds
is
reported.
The
proposed
method
features
the
use
non-noble
metal
catalysts,
capacity
utilizing
multiple
as
substrates,
simultaneous
formation
C-P
C-C
bonds
in
one
pot,
simplicity
its
operation,
mildness
reaction
conditions,
compatibility
a
wide
range
substrates.
Moreover,
it
offers
practical
route
direct
access
to
2-aryl-3-phosphino
Language: Английский
Substrate-Induced Cooperative Ionic Catalysis: Difunctionalization of Indole Derivatives Employing Dimethyl Carbonate
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(21), P. 15995 - 16003
Published: Oct. 21, 2024
The
global
urge
to
adopt
sustainable
chemistry
has
resulted
in
the
development
of
more
environmentally
benign
strategies
(EBS)
that
use
CO2
and
CO2-derived
chemicals
a
step-economic
manner.
In
this
context,
we
investigated
dual
C–H
methylation
(C═O)-methoxylation
indole
derivatives
using
dimethyl
carbonate
(DMC)
presence
catalytic
amounts
Cs2CO3.
Mechanistic
insights
include
DMF-assisted,
DMC-induced
cooperative
ionic
catalysis,
which
allows
DMC
act
as
both
nucleophilic
an
electrophilic
precursor,
resulting
N-benzylindolyl
ketones.
Language: Английский
Iodine‐Assisted Regioselective C3‐H Chalcogenation of 4‐Phenyl Aminocoumarin: Access to Unusual Dual Selenylation of N‐Substituted Derivatives
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 14, 2024
Abstract
A
simple,
efficient,
metal
and
photocatalyst‐free,
eco‐friendly
approach
for
the
C3‐H
regioselective
chalcogenation
of
4‐phenyl
aminocoumarin,
as
well
abnormal
dual
selenylation
N‐substituted
has
been
developed
by
using
diphenyl
dichalcogenides
iodine
support
in
green
solvent
PEG‐400
under
ambient
temperature
aerobic
condition.
Furthermore,
amino‐2‐pyrone
also
accomplished
similar
conditions.
The
proposed
mechanism
is
based
on
control
experiments
suggests
an
ionic
pathway.
reaction
offers
a
synthetic
path
with
high
yield,
methodology
crucially
significant
due
to
its
operational
simplicity,
convenient
execution,
scalability,
tolerance
various
functional
groups.
Language: Английский