Hydration Sensitive Orthogonal Dual Emission of a DNA‐Stabilized Silver Nanocluster

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(19)

Published: May 11, 2024

Abstract DNA‐stabilized silver nanoclusters (DNA‐AgNCs) are a class of emitters that have primarily been studied for their molecular‐like photophysical properties with ns‐lived fluorescence. However, µs‐lived luminescence has recently reported an increasing number DNA‐AgNCs, but little is still known about the origin long‐lived emission. To deepen understanding state, (DNA) 2 ‐[Ag 11 ] 7+ , emitter short‐ and dual emission, studied. By examining crystals it found fluorescence transitions orthogonal to each other, which implies components long axis AgNC, such as nucleobases, contribute significantly polarization character luminescent state. The effect hydration level on emission dried droplets also investigated, water drastically reduces from state causes redshift Finally, unusual excitation intensity‐dependent response noticed. This ascribed heterogeneous local environment amorphous solid resulting in different conformations optically activated delayed probabilities. presented results provide new key insights into nature DNA‐AgNCs.

Language: Английский

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Multi-Objective Design of DNA-Stabilized Nanoclusters Using Variational Autoencoders With Automatic Feature Extraction

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

DNA-stabilized silver nanoclusters (Ag

Language: Английский

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An Atom-Precise Understanding of DNA-Stabilized Silver Nanoclusters

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(15), P. 2117 - 2129

Published: July 12, 2024

ConspectusDNA-stabilized silver nanoclusters (Ag

Language: Английский

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Nanocluster Chemistry and the Role of in Situ Fluorescence as an Analytical Tool

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(19), P. 9003 - 9012

Published: May 28, 2024

Atomically precise metal nanoclusters are of high interest as photocatalysts, contrast agents for biomedical imaging, unique sensitizers therapies, and more. However, these fluorescent materials often synthesized mixtures, especially when stabilized by peptides other water-soluble ligands. Fluorescence spectroscopy, acquired a matrix excitation/emission spectra analyzed with principal component analysis, such parallel factor (PARAFAC) can be highly informative in assessing purity the number components sample. In this perspective, advances discussed, well use fluorescence excitation–emission spectroscopy (fEEM) fast, nondestructive technique sample composition. Hot topics cluster research including new classes clusters, theory-guided experiments, combination analytical techniques ensuring accurate structure–property studies discussed.

Language: Английский

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A Dual‐Emissive DNA‐Templated Silver Nanocluster with Near‐Infrared I and II Emission

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract DNA‐stabilized silver nanoclusters (DNA‐Ag N ) are atomically precise and sequence‐tuned nanomaterials with potential applications for deep tissue biomedical imaging. Here, a dual‐emissive DNA‐Ag is presented fluorescence in the first near‐infrared (NIR‐I) spectral window microsecond‐lived photoluminescence second (NIR‐II) window. High‐resolution electrospray ionization mass spectrometry showed that emitter has molecular formula (DNA) 2 [Ag 17 ] 11+ . The crystallization of was unsuccessful, which prevented use X‐ray diffraction to determine its structure. However, sequence variations templating DNA oligomer provided insights into nucleobases critical stabilizing Ag Moreover, addition an adenosine or thymidine at 5′‐end strand maintained composition photophysical properties , suggesting site conjugation biomolecules enable targeted labeling future bioimaging applications.

Language: Английский

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Revisiting Anti-Stokes Emission Features of DNA-Stabilized Silver Nanoclusters

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

DNA-stabilized silver nanoclusters (DNA-AgNCs) are a class of fluorophores with interesting photophysical properties. They capable generating anti-Stokes fluorescence upon excitation near-infrared lasers. The has previously been speculated to be either the result consecutive photon absorption (upconversion) or hot band (HBA). Here, we revisit DNA-AgNCs determine underlying mechanistic origin. We investigate two studied together organic and emission features in same spectral regions as DNA-AgNCs. From recorded spectra, find that all emitters exhibit an exponential-like decaying slope on red side lowest energy band. Furthermore, power dependency measurements at different wavelengths verify one-photon nature fluorescence. Ultimately, lack discrete optical transition spectra suggests HBA mechanism is most plausible cause for investigated

Language: Английский

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Two (AgI3I)4L4 cages elucidate the rules for silver-cluster vertex design

Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102456 - 102456

Published: March 1, 2025

Language: Английский

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Shining Bright at 960 nm: A 28‐Silver‐Atom Nanorod Stabilized by DNA

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Fluorescence imaging is a key tool in biological and medical sciences. Despite the potential for increased depth near‐infrared range, limited availability of bright emitters hinders its widespread implementation. In this work, DNA‐stabilized silver nanocluster (DNA–AgNC) with emission at 960 nm solution presented, which redshifts further to 1055 solid crystalline states. The atomic structure, composition charge DNA–AgNC are determined by combining single‐crystal X‐ray diffraction electrospray ionization–mass spectrometry. This unique atomically precise consists 28 atoms, neutral (Ag 16+ ), arranged rodlike shape, measures just over 2 length. Interestingly, differences observed number chlorido ligands between states, highlighting important but not yet fully understood role chlorides fine‐tuning optical properties class emitters. structure nanorod, along characterized photophysical properties, represents cornerstone understanding intricate interactions DNA bases, as well paving way rational design next‐generation probes.

Language: Английский

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Two-photon brightness of NIR-emitting, atomically precise DNA-stabilized silver nanoclusters

Published: June 7, 2024

Near-infrared (NIR) emitters with high two-photon absorption (2PA) cross-sections are of interest to enable in vivo imaging the tissue transparency windows. This study explores potential DNA-stabilized silver nanoclusters (AgN-DNAs) as water-soluble absorbers. We investigate 2PA four different atomically precise AgN-DNA species far-red NIR emission and varying nanocluster ligand compositions. cross-sections, σ2, were determined by excited luminescence (TPEL) technique for a wide wavelength range from 810 1400 nm. The AgN-DNAs exhibited reversed strength corresponding transitions regime, compared one-photon, which adds another puzzle complex photophysics these emitters. Maximal cross-section value (813 GM) was observed (DNA)3[Ag21]15+, is stabilized 3 DNA oligomers. (DNA)2[Ag16Cl2]8+ presented distinct behavior without chlorido ligands, presenting 176 GM at 1050 Our findings support NIR-to-NIR probes that both emit NIR. Their σ2 fluorescence quantum yield results superior brightness on order ~10^2 GM, significantly higher than organic fluorophores.

Language: Английский

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Synthesis of atomically precise Ag₁₆ nanoclusters and investigating solvent-dependent ultrafast relaxation dynamics

Nanoscale, Journal Year: 2024, Volume and Issue: 16(36), P. 16913 - 16918

Published: Jan. 1, 2024

Here we demonstrate the synthesis of atomically precise Ag 16 NCs and their photophysical properties. The solvent-dependent relaxation dynamics using ultrafast spectroscopy has been investigated.

Language: Английский

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